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Folding and aggregation studies in the acylphosphatase-like family
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Year: 2009 Publisher: Firenze Firenze University Press

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Abstract

Folding and misfolding of proteins are considered two sides of the same coin. The delicate equilibrium existing between these two processes is crucial for any living organism and its alterations can lead to the onset of several tremendous diseases, such as Alzheimer's and Parkinson's disease. The attainment of a profound knowledge of folding/misfolding processes is a key step to understand how life works and for discovering new therapies to these diseases. In this work the author shows that proteins can display enzymatic activity even in the absence of a compact three-dimensional structure, with important implications for the study of protein enzymes. Furthermore, the author investigates the formation of protein aggregates similar to those observed in patients of amyloid-related diseases.

Keywords

Medicina --- Biologia --- Chimica


Book
TOX: lezioni di tossicologia
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Year: 2006 Publisher: Firenze Firenze University Press

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TOX is a manual aimed primarily at the Toxicology courses of the Faculty of Pharmacy and Science, that can also be profitably utilised by students following different degree courses in other Faculties (Medicine, Agriculture, Engineering)and by anyone else looking for a thorough but succinct overview of toxicological questions. TOX covers the principal sectors of general toxicology (acute and chronic toxicity, mutagenesis, teratogenesis, carcinogenesis, reproductive toxicity, oxidative damage, epidemiological methods), specialist toxicology(dietary toxicity, tobacco smoke, pesticides, N-nitroso compounds, heterocyclic amines and aromatic amines toxicity) and environmental toxicology (environmental estrogens, PAH, heavy metals, dioxins and polychlorinated di-benzo-furans, water and air pollution).


Book
Alquimia del dolor. Estudios sobre medicina y literatura
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Year: 2014 Publisher: Publicacions Universitat Rovira i Virgili

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Alquimia del dolor pretende explorar las relaciones entre medicina y literatura tanto en la perspectiva de la más exigente investigación académica como desde el punto de vista de la utilidad de los textos literarios en la formación de los profesionales de la salud. Su tema lo constituyen las reflexiones de algunos de los más importantes creadores de la literatura occidental sobre los tres grandes asuntos que estructuran la obra: «la enfermedad, la muerte y la medicina», «el inconsciente y la locura» y «las ciencias de la vida en el espejo de la literatura». Los estudios que componen el libro son el resultado del trabajo de su autor durante más de treinta años en este ámbito de investigación y docencia universitaria.


Book
Immagini di Istopatologia : Atlante per le esercitazioni di Patologia Generale
Authors: ---
Year: 2007 Publisher: Firenze University Press

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This collection of images of Histopathology is the fruit of the authors' thirty years' experience in the performance of practical exercises in General Pathology. It is aimed at students attending lessons of General Pathology on the Degree Courses in Medical Surgery and Biological Sciences. It does not aspire either to be complete from the point of view of the various organic pathologies, or to replace direct and personal observation of the histological preparations through the microscope, but is rather intended as an aid to students preparing for the exam. It does not include the rudiments of cytology and microscopic anatomy, which it is assumed have already been mastered by those approaching General Histopathology, nor are histopathological phenomena systematically addressed, for which the reader is referred to textbooks on General Pathology. The 44 preparations presented here have been grouped in line with the main arguments of General Pathology: Cellular Degeneration, Inflammation, Neoplasia both benign and malign, and Vascular Pathology. They have been selected for their didactic significance and the simplicity and clarity of the lesions present, without taking into account the information to be derived from the clinical case history. The images of the preparations, in which the best possible quality of reproduction has been sought, are presented in progressive enlargements and are accompanied by brief descriptions comprising the explanations essential for identification of the characteristic aspects of the elementary lesion, as well as any eventual defects in the preparations themselves. Effectively, the objective of the work is to enable the student to exercise his understanding of the images. For this reason the casuistics included is as essential as possible, and the method of presentation utilised is designed to avoid mere visual memorisation, stimulating first analysis and then synthesis, and the development of individual logical skills so as to indicate whether aspects of cellular pathology, inflammation or neoplasia are present.


Book
Ars medica : la medicina en l'època romana
Authors: ---
ISBN: 848424587X 8484245861 Year: 2017 Publisher: Publicacions Universitat Rovira i Virgili

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En les pàgines d’aquest llibre s’hi agrupen alguns dels aspectes de la medicina a Roma prenent com a referència les fonts arqueològiques, epigràfiques i literàries. També hi trobem, en alguns casos, una nova visió d’aquests temes que s’aparta de l’androcentrisme que ha estat present en els estudis de la història, la literatura i l’arqueologia clàssica des de fa molts segles. Aquest fet ens permet tenir una percepció més completa d’una de les peces que componen el món grecoromà.


Book
Approach to internal medicine : a resource book for clinical practice
Authors: --- ---
ISBN: 3030729796 303072980X Year: 2022 Publisher: Cham, Switzerland : Springer,

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La relación médico-paciente
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Year: 2018 Publisher: Publicacions i Edicions de la Universitat de Barcelona

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La relación médico-paciente está sometida a varias presiones. La financiación de la asistencia sanitaria puede determinar tanto la percepción colectiva del acceso a los recursos sociales (prestaciones económicas, centros de atención especializada, ayudas a domicilio, entre otros) como la prescripción de medicamentos y de pruebas complementarias. Además de las prioridades del financiador o de los beneficiarios de los resultados económicos, las campañas publicitarias influyen también en el criterio del paciente, al que la industria farmacéutica halaga convenciéndolo de que posee conocimientos de medicina y de que es un consumidor con el poder de escoger, cuando en realidad decide porque tiene los medios económicos para pagar su elección. En este libro se analizan las razones que empujan a los profesionales de la sanidad hacia una parcialidad interesada, así como las consecuencias éticas que ello tiene sobre el individuo y sobre la eficiencia del sistema sanitario.


Periodical
Medicinageneralydefamilia.
Author:
ISSN: 18895433 Year: 2009 Publisher: Sant Cugat del Vallés (Barcelona) : Editorial Alternativa,

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Book
Common Chinese materia medica.
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ISBN: 9811620628 981162061X Year: 2021 Publisher: Singapore : Springer,

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Book
Common Chinese materia medica.
Author:
ISBN: 9811620660 9811620652 Year: 2021 Publisher: Singapore : Springer,

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