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Human red blood cells are formed mainly in the bone marrow and are believed to have an average life span of approximately 120 days. However, is it true for all red blood cells? What are the changes associated with red cell maturation, adulthood and senescence? What are the determinants of red cell life span and clearance? What are the mechanisms in control of red cell mass in healthy humans and patients with various forms of anemia? What are the markers of circulating red cell senescence and in cells during storage and transfusion? Within the life span may properties of red cells change leading to age-mixed circulating cell populations. Although these cells appear to be genetically terminated by the time they are released into the blood stream, they undergo surprisingly versatile modifications depending on the life-style and health conditions of a “human host”. Numerous disorders are believed to be associated with facilitated ageing of red blood cells. “In vitro ageing” and damage of red blood cells during storage is yet one more important issue related to the risks and efficiency of blood transfusion. Many of the mechanisms behind such effects are far from being fully understood. In this context the Research Topic is set to include articles in the field of biochemical investigations, biophysical approaches, physiological and clinical studies related to red blood cell maturation and aging. This includes Original Research, Methods, Hypothesis and Theory, Reviews and Perspectives.

Erythropoiesis --- senescence --- neocytolysis --- blood storage --- Clearance --- Vesiculation --- erythrocyte

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This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact

leaf senescence --- stay green --- environmental stress --- phytohormones --- transcription factors

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Cell cycle --- Cell Cycle. --- DNA Damage. --- Cell Aging. --- Cell cycle. --- Celcyclus. --- Mitotic cycle --- Nuclear cycle (Cytology) --- Cellular Aging --- Aging, Cell --- Cell Senescence --- Replicative Senescence --- Senescence, Cellular --- Senescence, Replicative --- Aging, Cellular --- Cellular Senescence --- Senescence, Cell --- Injury, DNA --- DNA Injury --- Genotoxic Stress --- Stress, Genotoxic --- DNA Damages --- DNA Injuries --- Damage, DNA --- Damages, DNA --- Genotoxic Stresses --- Injuries, DNA --- Stresses, Genotoxic --- Cell Division Cycle --- Cell Cycles --- Cell Division Cycles --- Cycle, Cell --- Cycle, Cell Division --- Cycles, Cell --- Cycles, Cell Division --- Division Cycle, Cell --- Division Cycles, Cell --- Biological rhythms --- Cell Ageing --- Cellular Ageing --- Senescence-Associated Secretory Phenotype --- Cell Aging --- Ageing, Cell --- Ageing, Cellular --- Phenotype, Senescence-Associated Secretory --- Secretory Phenotype, Senescence-Associated --- Senescence Associated Secretory Phenotype --- Aging --- Mutation --- Pyrimidine Dimers --- Comet Assay --- DNA Repair Enzymes --- Cell Cycle Proteins --- Genes, cdc --- Cellular Senescence. --- Cell Cycle --- DNA Damage --- Cytologie --- Cellules --- Life Sciences --- Biology --- Cytology, Cell Biology --- DNA damage. --- Cells --- Cytology --- Cycle cellulaire --- Cycle cellulaire. --- ADN --- Aging. --- Lésions. --- Vieillissement. --- Biochemical genetics --- Mutation (Biology) --- Organisms --- Cytology. --- Cells. --- Cell biology --- Cellular biology

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This book provides an underexplored view of ageing, one that conceives older people as valuable resources in their communities, as active citizens with both voice, and an agency that includes the capacity for resistance. It acknowledges that becoming old with dignity means also paying attention to caring, good health services and the possibility of good death. The book defines age and ageing as multiple, culturally and historically constructed phenomena that are only loosely connected to the years of one’s life. In focusing on the peripheral North located in the Nordic, Canadian and Russian north, it highlights important questions and viewpoints that can be found and adapted to other rural areas. The book answers the following questions: What is the relevance of legislation and international legal agreements in ensuring the rights of elderly people under political and economic changes? What challenges do geographic isolation, changing age structure, and cultural and ecological transformations pose to possibilities for meeting older people’s needs for engagement in society as well as for their care? As such this book will be of interest to all those working in population aging.

Aging --- Aging. --- Research. --- Age --- Ageing --- Senescence --- Developmental biology --- Gerontology --- Longevity --- Age factors in disease --- Physiological effect

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Explains human aging from genes to clinical disease. With over 4,000 references, this book explores both the fundamental processes of aging and the resultant tissue-by-tissue clinical pathology, detailing both research and state-of-the art clinical interventions in aging and age-related disease.

Aging. --- Cells --- Aging --- Age --- Ageing --- Senescence --- Developmental biology --- Gerontology --- Longevity --- Age factors in disease --- Physiological effect