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This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact

sudden death --- blood pressure --- apnea --- sleep --- ketogenic diet --- epilepsy --- seizures --- mortality

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Heart --- Sudden death. --- Heart failure. --- Diseases --- Diagnosis. --- Cardiac failure --- Cardiac insufficiency --- Failure, Heart --- Insufficiency, Cardiac --- Cardiac arrest --- Death --- Mortality --- Causes

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With upwards of 4.5 million deaths worldwide each year, and more than one tenth of these occurring in those with no previously documented heart disease, sudden arrhythmic death (SAD) is both a major public health burden and a highly emotive issue for society at large. Recent years have witnessed a marked expansion in our knowledge of the physiology underlying SAD, both in the context of hereditary and acquired cardiac disorders. Thanks largely to work in genetically modified animals, the growth in our understanding of mechanisms underlying arrhythmia in the hereditary channelopathies has been particularly marked. Our growing knowledge of the fundamental mechanisms underlying SAD has so far failed to spur substantial developments in clinical practice. Despite a large body of work in both humans and animals, it remains impossible to confidently identify those at high risk of SAD, making pre-emptive therapy a challenge. What is more, with the thankful exception of the implantable cardioverter-defibrillators and pharmacological agents in very specific situations, there has been depressingly little progress in finding new and effective therapies. This Research Topic aims to go some way towards bridging the gap between advances in basic science and the development and delivery of new therapies. It brings together original research contributions and review articles from key opinion leaders in the field, focusing on the direct clinical implications of the basic science research now and in the future.

Sudden death. --- Sudden death --- Cardiac arrest --- Prevention. --- Pathophysiology. --- Death --- Mortality --- Causes --- Arrest, Cardiac --- Cardiopulmonary arrest --- Heart arrest --- Sudden cardiac death --- Heart --- Heart failure --- Diseases --- ventricular arrhythmia --- Inherited arrhythmia syndromes --- sudden death --- arrhythmia mechanisms --- Channelopathies --- ventricular tachycardia --- cardiac modelling --- Ventricular Fibrillation --- Atrial Fibrillation --- Brugada Syndrome

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This book considers the practical management of sudden death and offers first-hand reflections of how emergency physicians, nurses, and allied health professionals cope. Sudden death is one of the most difficult aspects of emergency care, and the traumatic nature of some deaths can be devastating for the family and the emergency team. This book shows how practitioners confront the sudden death and the essential steps taken to manage the event that may have a critical impact on the grieving relative. The book explores the unique interactions between emergency and allied health practitioners and nurses, those who grieve and, the body itself. By understanding what is involved in sudden death work, and the practical, psychosocial and spiritual tensions that arise from managing the event and sequel, it may be possible to provide a more responsive service. The book addresses sudden death from the multi-professional emergency and allied services perspective to guide either the seasoned practitioners or the new and apprehensive recruit. National emergency response systems have been strengthened to cope with the increasing trauma and disease burden which, for many unfortunate individuals, results in an immediate or swift death trajectory. This multidisciplinary teaching text uses first-hand detailed stories of sudden death encounters. By reflecting on these ‘happenings’ and illuminating on how specific events were handled, it is possible to build a picture not only of what sudden death workers ‘do’ when sudden death occurs but also how they feel about what they ‘do’. At the end of each chapter a series of activities will be posed to encourage the reader to make sense of their own practices when handling the legal and practical aspects and when supporting families and colleagues.

Nursing. --- Emergency medicine. --- Emergency Services. --- Medicine, Emergency --- Medicine --- Critical care medicine --- Disaster medicine --- Medical emergencies --- Clinical nursing --- Nurses and nursing --- Nursing process --- Care of the sick --- Sudden death. --- Death --- Mortality --- Causes

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Crib death (SIDS) is the most frequent cause of death for infants during the first year, striking 1 out of every 700-1,000. Scarce knowledge in the field of SIDS and its pathology has led to a continued and growing concern with finding an explanation, with the goal of being able to either predict or quickly diagnose the infant or term fetus. A systematic study of the autonomic nervous system and cardiac system has been performed on a large number of infants and fetuses who died suddenly and unexpectedly, as well as in age-matched control cases. The neurological and cardiac findings are described here, and the relationship between SIDS and unexplained fetal death is discussed. This book helps pathologists, forensic pathologists, pediatricians, obstetrics, and neonatologists in recognizing all potential morphological substrata and puts forward a well-researched postmortem study for use in a standardized autopsy protocol for use in all cases of sudden unexpected infant and fetal death.

Sudden infant death syndrome. --- Cot death --- Crib death --- Infant sudden death --- SIDS (Disease) --- Sudden death in infants --- Sudden infant death --- Infants --- Syndromes in children --- Death --- Pathology. --- Forensic Medicine. --- Pediatrics. --- Emergency medicine. --- Obstetrics. --- Emergency Medicine. --- Obstetrics/Perinatology/Midwifery. --- Maternal-fetal medicine --- Medicine --- Medicine, Emergency --- Critical care medicine --- Disaster medicine --- Medical emergencies --- Paediatrics --- Pediatric medicine --- Children --- Forensic medicine --- Injuries (Law) --- Jurisprudence, Medical --- Legal medicine --- Forensic sciences --- Medical laws and legislation --- Disease (Pathology) --- Medical sciences --- Diseases --- Medicine, Preventive --- Health and hygiene --- Forensic medicine. --- Medical jurisprudence.