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The march to the Trump presidency began in 1988, when Rush Limbaugh went national. Brian Rosenwald charts the transformation of AM radio entertainers into political kingmakers. By giving voice to the conservative base, they reshaped the Republican Party and fostered demand for a president who sounded as combative and hyperbolic as a talk show host.

Radio talk shows --- Right-wing extremists --- Radio talk show hosts --- Radio in politics --- Conservatism --- Political parties --- Political aspects --- Republican Party (U.S. : 1854- ) --- United States --- Politics and government

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Many of the most prevalent and devastating human and animal pathogens have part of their lifecycle out-with the animal host. These pathogens have a remarkably wide capacity to adapt to a range of quite different environments: physical, chemical and biological, which is part of the key to their success. Many of the well-known pathogens that are able to jump between hosts in different biological kingdoms are transmitted through the faecal-oral and direct transmission pathways, and as such have become important food-borne pathogens. Some high-profile examples include fresh produce-associated outbreaks of Escherichia coli O157:H7 and Salmonella enterica. Other pathogens may be transmitted via direct contact or aerosols are include important zoonotic pathogens. It is possible to make a broad division between those pathogens that are passively transmitted via vectors and need the animal host for replication (e.g. virus and parasites), and those that are able to actively interact with alternative hosts, where they can proliferate (e.g. the enteric bacteria). This research topic will focus on plants as alternative hosts for human pathogens, and the role of plants in their transmission back to humans. The area is particularly exciting because it opens up new aspects to the biology of some microbes already considered to be very well characterised. One aspect of cross-kingdom host colonisation is in the comparison between the hosts and how the microbes are able to use both common and specific adaptations for each situation. The area is still in relative infancy and there are far more questions than answers at present. We aim to address important questions underlying the interactions for both the microbe and plant host in this research topic.

Botany --- Microbiology --- Pathogenic microorganisms --- Pathogenic microorganisms. --- Research. --- Geographical Subject Heading. --- Disease-causing microorganisms --- Micro-organisms, Pathogenic --- Pathogens --- Microorganisms --- Medical microbiology --- Virulence (Microbiology) --- Microbial biology --- Biology --- Botanical science --- Floristic botany --- Phytobiology --- Phytography --- Phytology --- Plant biology --- Plant science --- Natural history --- Plants --- Salmonella enterica --- Escherichia coli --- fresh produce --- Effectors --- Plant hosts --- PAMP triggered immunity --- Organic vegetable --- microbiome --- Arabidposis thaliana --- mRNA extraction

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G-quadruplexes (G4s) are nucleic acids secondary structures that form in DNA or RNA guanine (G)-rich strands. In recent years, the presence of G4s in microorganisms has attracted increasing interest. In prokaryotes, G4 sequences have been reported in several human pathogens. Bacterial enzymes able to process G4s have been identified. In viruses, G4s have been suggested to be involved in key steps of the viral life cycle: They have been associated with the human immunodeficiency virus (HIV), herpes simplex virus 1 (HSV-1), human papilloma virus, swine pseudorabies virus, and other viruses’ genomes. New evidence shows the presence of G4s in parasitic protozoa, such as the causative agent of malaria. G4 binding proteins and mRNA G4s have been implicated in the regulation of microorganisms’ genome replication and translation. G4 ligands have been developed and tested both as tools to study the complexity of G4-mediated mechanisms in the viral life cycle and as therapeutic agents. Moreover, new techniques to study G4 folding and their interactions with proteins have been developed. This Special Issue will focus on G4s present in microorganisms, addressing all the above aspects.

bacteria --- folding --- co-translational refolding --- RecQ helicase --- regulatory element --- conformational dynamics --- G4Hunter --- NDPK --- fluorescence --- pseudorabies virus --- Epstein-Barr virus (EBV) --- structure-activity relationship --- PhenDC3 --- eukaryotic hosts --- Herpesvirus --- translation suppression --- turn-on ligands --- co-transcriptional folding --- Herpesviridae --- G-quadruplex --- nucleoside diphosphate kinase --- nucleic acids --- nucleic acids conformation --- bioinformatics --- protein–DNA interaction --- aptamers --- deinococcus --- Alphaherpesvirinae --- EBNA1 --- G4 --- virus --- human papillomaviruses --- S. cerevisiae --- genome stability --- G-quadruplexes --- metastable structure --- genome evolution --- pyridostatin --- alphaherpesviruses --- structure --- protozoa --- genome --- G-quadruplex ligand --- NMR --- microbes --- DNA --- protein-mRNA interactions --- G-quadruplex formation --- immediate early promoters

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This book is a printed edition of the Special Issue Fungal Infections in Immunocompromised Hosts that was published in JoF

toxicity --- risk assessment --- species complex --- galactomannan --- taxonomy --- Aspergillus PCR --- candidemia --- adaptive immunity --- fungal immunity --- T2 Candida --- anti-fungal agents --- innate immunity --- antifungal stewardship --- Immunotherapy --- Candida meningoencephalitis --- liposomal amphotericin B --- anidulafungin --- liver disease --- invasive mold disease --- T2Candida --- AIDS --- (1?3)-?-d-glucan --- literature review --- yeast --- hepatic impairment --- prediction models --- IRIS --- invasive aspergillosis --- antifungal agent --- TNF inhibitors --- Aspergillus fumigatus --- fungal nomenclature --- micafungin --- non-culture-based diagnostics --- PCR --- paracoccidioidomycosis --- Candida auris --- multidrug resistance --- subcutaneous mycoses --- risk score --- mycoses of implantation --- Sporothrix brasiliensis --- antifungal resistance --- immunocompromised hosts --- Sporothrix schenckii --- Aspergillus --- fungus --- cell therapy --- MALDI-ToF MS --- lateral flow --- phylogenetics --- hematological malignancy --- candidiasis --- antifungal drug --- hematological malignancies --- mycoses --- invasive fungal infections --- lymphoma --- kidney transplant --- immune reconstitution inflammatory syndrome --- mechanisms of antifungal resistance --- fungal infections --- cytokine therapy --- sporotrichosis --- beta-d-glucan --- invasive fungal infection --- HIV --- cat-transmitted sporotrichosis --- aspergillosis --- cancer --- prognostic risk model