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With contributions from internationally recognized experts, Lung Cancer details the current management of lung cancer and reviews new therapies in development for lung cancer, with an emphasis on therapeutic exploitation of the heterogeneous nature of lung tumors at the molecular level. Coverage includes discussion of multiple new agents that have been shown to impact overall survival as well as articles covering molecular biology of lung cancer, chemotherapy regimens for lung cancer, the emergence of maintenance therapy, the complexity of radiotherapy in the chest, the impact of adjuvant chem
Lungs --- Lung cancer --- Cancer.
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Lungs --- Lung cancer --- Cancer.
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Lungs --- Lung cancer --- Cancer.
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"Get a quick, expert overview of the many key facets of lung cancer evaluation and management with this concise, practical resource. This easy-to-read reference presents a summary of today's best evidence-based approaches to diagnosis and management in this critical area."--
Lungs --- Cancer. --- Lung cancer
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Lung cancer is the number one cause of cancer deaths around the world. This devastating disease takes strength not only in people who smoke but also in poor people that eat polluted food and use heating sources, and in those exposed naturally to toxic compounds present in indoor and outdoor environments. Lung cancer patients and their families wait actions from the science that give not only answer to their demands but also a light of hope at the moment of receiveing the diagnosis. This book meets the experience of several researchers who dedicate many hours a day to find not only the cure of lung cancer but also the way to convert the pathology of this chronic disease. In 12 chapters, the lectures will give information related to the relationship of lung cancer and smoking habit, the crucial role of the image technology for diagnosis of lung cancer, and a molecular vision of prevention, diagnosis, and treatment of lung cancer. The authors with a clinic and/or lab vision and with a great spirit to collaborate with the science and with each past, present, and future patient and their families have dedicated many hours to write each chapter. Probably, the final answer to find the cure of lung cancer is not in this book. However, the lectures will give scientific information that will contribute in the near future improvement to the life quality of the patients.
Lungs --- Cancer. --- Lung cancer --- Medicine --- Pulmonology --- Internal Medicine --- Health Sciences
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Lungs --- Lung Neoplasms. --- Cancer --- Cancer. --- Lung Cancer. --- Cancer of the Lung --- Neoplasms, Lung --- Neoplasms, Pulmonary --- Cancer of Lung --- Lung Cancer --- Pulmonary Cancer --- Pulmonary Neoplasms --- Cancer, Lung --- Cancer, Pulmonary --- Cancers, Lung --- Cancers, Pulmonary --- Lung Cancers --- Lung Neoplasm --- Neoplasm, Lung --- Neoplasm, Pulmonary --- Pulmonary Cancers --- Pulmonary Neoplasm --- Lung --- Lung cancer --- lung cancer --- palliative care --- cancer screening --- Cardiopulmonary system --- Chest --- Respiratory organs --- Oncology. Neoplasms
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Lungs --- Cancer --- Cancer. --- Lung cancer --- Lung --- Cardiopulmonary system --- Chest --- Respiratory organs --- Health Sciences --- Oncology
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This study shows convincingly that denial in lung cancer patients deserves attention in clinical practice.
Lungs --- Lung --- Cardiopulmonary system --- Chest --- Respiratory organs --- Lung cancer --- Cancer. --- Cancer --- Patients --- Psychology.
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Lungs --- Lung cancer --- Cancer. --- Lung Neoplasms --- Carcinoma, Non-Small-Cell Lung --- pathology --- therapy
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Approximately 40% of lung cancer patients will develop central nervous system (CNS) metastases during the course of their disease. Most of these are brain metastases, but up to 10% will develop leptomeningeal metastases. Known risk factors for CNS metastases development are small cell lung cancer (SCLC), adenocarcinoma histology, epidermal growth factor receptor (EGFR) mutant or anaplastic lymphoma kinase (ALK) rearranged lung cancer, advanced nodal status, tumor stage and younger age. CNS metastases can have a negative impact on quality of life (QoL) and overall survival (OS). The proportion of lung cancer patients diagnosed with CNS metastases has increased over the years due to increased use of brain imaging as part of initial cancer staging, advances in imaging techniques and better systemic disease control. Post contrast gadolinium enhanced magnetic resonance imaging (gd-MRI) is preferred, however when this is contra-indicated a contrast enhanced computed tomography (CE-CT) is mentioned as an alternative option. When CNS metastases are diagnosed, local treatment options consist of radiotherapy (stereotactic or whole brain) and surgery. Local treatment can be complicated by symptomatic radiation necrosis for which no high level evidence based treatment exists. Moreover, differential diagnosis with metastasis progression is difficult. Systemic treatment options have expanded over the last years. Until recently, chemotherapy was the only treatment option with a poor penetration in the CNS. Angiogenesis inhibitors are promising in the treatment of primary CNS tumors as well as radiation necrosis but clinical trials of anti-angiogenic agents in NSCLC have largely excluded patients with CNS metastases. Furthermore, research has also focused on methods to prevent development of CNS disease, for example with prophylactic cranial irradiation. Recently, checkpoint inhibitors have become available for NSCLC patients, and tyrosine kinase inhibitors (TKIs) have improved prognosis significantly in those with a druggable driver mutation. Newer TKIs are often designed to have better CNS penetration compared to first-generation TKIs. Despite advances in treatment options CNS metastases remain a problem in lung cancer and cause morbidity and mortality. This Research Topic provides an extensive resource of articles describing advances in CNS metastases management in lung cancer patients, from prevention to diagnosis and treatment.
lung cancer --- driver mutations --- treatment --- brain metastases --- leptomeningeal metastases --- cranial radiation --- prediction --- diagnosis
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