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Explores the stable core of Wittgenstein's philosophy as developed from the Tractatus to the Philosophical Investigations.

Wittgenstein, Ludwig, --- Wei-tʻe-ken-ssu-tʻan, --- Wei-tʻe-ken-ssu-tʻan, Lu-te-wei-hsi, --- Wittgenstein, L. --- Vitgenshteĭn, L., --- Wei-ken-ssu-tʻan, --- Pitʻŭgensyutʻain, --- Vitgenshteĭn, Li︠u︡dvig, --- Weitegenshitan, --- Wittgenstein, Ludovicus, --- Vitgenshtaĭn, Ludvig, --- ויטגנשטיין, לודוויג --- 维特根斯坦, --- Wittgenstein, Ludwig Josef Johann, --- Philosophy, Modern --- Wittgenstein, Ludwig

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In the past few years, knowledge about glaucoma diagnosis and follow up has evolved dramatically through advances in intraocular pressure (IOP) measurement, corneal biomechanics, structural and functional assessment of the ocular surface, anterior chamber, retina, optic nerve and intracranial visual pathways, as well as the advent of artificial intelligence. In addition, the development of new modalities of IOP-lowering and non-IOP-lowering drugs, alternative deliveries, refined laser technologies, and minimally invasive glaucoma surgery (MIGS) techniques with different implants have widened the therapeutic possibilities for treating this disease. Finally, current insights into risk factors and quality of life in relation to glaucomatous impairment are emerging. The purpose of this Special Issue is to present the latest exciting clinical developments that are taking place in the field of glaucoma.

ripasudil --- suture trabeculotomy ab interno --- Schlemm’s canal incision --- aqueous outflow --- open-angle glaucoma --- glaucoma --- inflammation --- oxidative stress --- phenotype --- polymorphism --- susceptibility --- intraocular pressure --- ocular inflammation --- cornea biomechanics --- Corvis® ST --- subclinical keratoconus --- ocular hypertension --- tears --- miRNAs --- next generation sequencing --- biomarkers --- genes --- signaling pathways --- apoptosis --- neurodegeneration --- glaucoma suspect --- lamina cribrosa --- optical coherence tomography angiography --- peripapillary vessel density --- OCTA --- vessel density --- disc --- peripapillary --- NTG --- BRVO --- corneal hysteresis --- corneal biomechanics --- ocular biomarkers --- deep learning --- perimetry --- optic nerve --- obesity --- risk factor --- young adults --- multifocal visual evoked potentials --- mfVEP --- physical exercise --- sport --- acrobatic gymnastics --- baseline intraocular pressure --- central corneal thickness --- ocular health --- tumbling skills --- hand balance --- cytokines --- BDNF --- VEGF --- fractalkine --- microglia --- saffron --- crocin --- retinal glial cells --- microperimetry --- OCT --- macula --- structure --- function --- correlation --- retina --- inner --- outer --- macular segmentation --- optical coherence tomography-angiography --- vascular density --- blood flow --- biomarker --- myopia --- n/a --- Schlemm's canal incision

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Mental chronometry can be defined as the measurement of response time and has been a fundamental tool in the non-invasive study of sensory perception and cognition and in human task performance over more than a century. Mental chronometry has evolved from different methodologies and mathematical models into a standard paradigm to study unsolved problems in human neuroscience and psychophysics. Typical examples are the extensive research on simple and choice reaction times in perceptual-motor tasks, response timing; estimation of temporal intervals, temporal-order detection, etc. In addition, the combination of brain imaging and neurophysiological techniques with mental chronometry has opened new perspectives and has provided new insights into temporal coding, organization and efficiency of internal processing stages and neural activity in multiple tasks. Examples are the analysis of reaction times together with event-related potentials, transcranial magnetic stimulation, functional magnetic resonant imaging, etc. This Research Topic will focus on recent advances of mental chronometry at all levels of analysis. Thus we welcome hypothesis & theory, methods, opinion, reviews, mini reviews, perspective, clinical case study and original research papers on the fundamentals on mental chronometry; papers at the interface between mental chronometry and other non-invasive techniques and papers on mental chronometry with applications in areas such as computational neuroscience, neural networks, brain diseases, animal models, artificial intelligence, robotics, etc.

Time perception. --- Time perception disorders. --- Neurology --- Research. --- power laws --- Decision Making --- Timing and Time perception --- mental chronometry --- stochastic models --- Simple and choice reaction time --- Cognition --- human performance --- variability --- Sensory Perception