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Water-electrolyte imbalances. --- Acid-base imbalances. --- Water-electrolyte imbalances --- Acid-base imbalances --- Water-Electrolyte Imbalance --- Acid-Base Imbalance --- Potassium --- physiopathology. --- diagnosis. --- metabolism. --- physiopathology --- diagnosis --- metabolism --- Water-electrolyte balance (Physiology) --- Acid-base equilibrium --- Kalium --- Alkali metals --- High-potassium diet --- Low-potassium diet --- Acid-base disorders --- Acid-base imbalance --- Imbalances, Acid-base --- Body fluid disorders --- Electrolyte disorders --- Electrolyte-water imbalances --- Imbalances, Water-electrolyte --- Water-electrolyte imbalance --- Electrolyte-water balance (Physiology) --- Fluid-electrolyte balance (Physiology) --- Water balance (Physiology) --- Homeostasis --- Aquaporins --- Fluid therapy --- Osmoregulation

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This Special Issue, “Plant Oxidative Stress: Biology, Physiology, and Mitigation”, published 11 original research works and 1 review article that discussed the various aspects of ROS Biology, metabolism, and the physiological mechanisms and approaches to mitigating oxidative stress. These types of research studies show further directions for the development of crop plants that are tolerant to abiotic stress in the era of climate change.

heat stress --- grafting --- cucumber --- bitter-melon rootstock --- polyamines --- photosynthesis --- salicylic acid --- chlorophyll fluorescence --- excess boron --- lipid peroxidation --- enzymatic antioxidant --- glutathione --- proline --- stomatal conductance --- arsenic stress --- soybean --- growth --- antioxidant enzymes --- ascorbate–glutathione cycle --- glyoxalase system --- altitudinal variation --- antioxidant activity --- bioactive compounds --- endemic species --- oxidative damage --- sequential application of antioxidants --- salinity --- Cucumis sativus --- photosynthetic efficiency --- antioxidant defense systems --- antioxidants --- cadmium --- oxidative stress --- peptone --- spinach --- alpha-tocopherol --- foliar spray --- okra varieties --- salt --- drought --- plants --- ROS --- genomics --- approaches --- integration --- abiotic stress --- antioxidant defense --- phytohormones --- pulse crop --- water deficit --- AsA-GSH pathway --- methylglyoxal --- micronutrient --- osmoregulation --- reactive oxygen species --- trace elements --- Olea europaea L. --- selenium biofortification --- olive pollen --- cytosolic Ca2+ --- Cucurbita pepo (L.) --- mineral uptake --- nucleic acids --- n/a --- ascorbate-glutathione cycle

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Aquaculture is an important economic activity for food production all around the world that has experienced an exponential growth during the last few decades. However, several weaknesses and bottlenecks still need to be addressed in order to improve the aquaculture productive system. The recent fast development of the omics technologies has provided scientists with meaningful tools to elucidate the molecular basis of their research interests. This reprint compiles different works about the use of transcriptomics and genomics technologies in different aspects of the aquaculture research, such as immunity, stress response, development, sexual dimorphism, among others, in a variety of fish and shellfish, and even in turtles. Different transcriptome (mRNAs and non-coding RNAs (ncRNAs)), genome (Single Nucleotide Polymorphisms (SNPs)), and metatranscriptome analyses were conducted to unravel those different aspects of interest.

Research & information: general --- Biology, life sciences --- Fisheries & related industries --- RNA-Seq --- lncRNAs --- Dicentrarchus labrax --- viral infection --- nodavirus --- immune response --- fish --- T lymphocytes --- infection --- malnutrition --- inflammation --- aquaculture --- histopathology --- immunohistochemistry --- enteromyxosis --- Philasterides dicentrarchi --- turbot --- transcriptomics --- Chinese mitten crab --- Eriocheir sinensis --- transportome --- transporters --- salinity --- osmoregulation --- transcriptome --- meta-analysis --- gills --- short pentraxins --- c-reactive protein --- zebrafish --- transcript expression --- antiviral --- SVCV --- rag1 mutants --- skin --- mucosal immunity --- hypoxia --- hypo-metabolic state --- growth --- swimming performance --- metabolic landmarks --- muscle transcriptome --- glycolysis --- lipid metabolism --- protein turnover --- gilthead sea bream --- hepatopancreas necrosis disease --- metatranscriptomics sequencing --- hepatopancreatic flora --- teleost --- B cells --- single cell transcriptomics --- immunoglobulins --- immune markers --- transcription factors --- long non-coding RNAs --- hepatic transcript expression --- salmon --- microarray --- omega-6/omega-3 ratio --- nutrigenomics --- fatty acids --- liver --- muscle --- Misgurnus anguillicaudatus --- sexual size dimorphism --- polyploid size dimorphism --- comparative transcriptome --- gene expression --- edible red sea urchin --- Loxechinus albus --- RNA-seq --- reference transcriptome --- Chinese soft-shelled turtle --- Aeromonas hydrophila --- hemorrhagic sepsis --- molecular immunopathogenesis --- tripartite motif proteins --- B30.2 domain --- antiviral immunity --- Ctenopharyngodon idella --- grass carp reovirus --- metamorphosis --- brain --- RNA --- sequencing --- intermuscular bone --- development --- Megalobrama amblycephala --- Oreochromis niloticus --- histological structure --- Atlantic salmon --- smoltification --- genome --- mRNAs --- miRNAs --- sox family genes --- Pelodiscus sinensis --- estradiol --- pseudo-female --- sex-related --- heterosis --- heterobeltiosis --- environment --- transgressive genes --- conserved miRNA --- high-throughput sequencing --- lumpfish --- novel miRNA --- RT-qPCR --- heat shock protein --- co-chaperon network --- salinity-alkalinity adaptation --- molecular evolution --- Lateolabrax maculatus --- genomics --- stress response --- HPI-axis --- neuroendocrine-immune interaction --- common carp --- poly-unsaturated fatty acid --- fatty acid elongase --- association study --- genomic selection --- bulked segregant analysis --- SNP --- association analysis --- joint effect --- seawater adaptation --- microRNAs --- small-RNA sequencing --- microarray transcriptome --- European seabass --- chronic inflammation --- opioid receptors --- immune status --- whole-transcriptome sequencing --- sex differentiation --- non-coding RNAs --- ceRNA --- red cusk-eel --- thermal stress --- liver transcriptome --- oxidative damage --- protein folding --- hepatic enzymes --- n/a

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For a long time, the tight junction (TJ) was known to form and regulate the paracellular barrier between epithelia and endothelial cell sheets. Starting shortly after the discovery of the proteins forming the TJ—mainly the two families of claudins and TAMPs—several other functions have been discovered, a striking one being the surprising finding that some claudins form paracellular channels for small ions and/or water. This Special Issue includes 43 articles covering numerous dedicated topics including pathogens affecting the TJ barrier, TJ regulation via immune cells, the TJ as a therapeutic target, TJ and cell polarity, function and regulation by proteins of the tricellular TJ, TJ as a regulator of cellular processes, organ- and tissue-specific functions, TJ as sensors and reacting to environmental conditions, and last but not least, TJ proteins and cancer.

tissue barrier --- tight junction --- claudins --- tricellulin --- tight junctions --- organ preservation --- intestine --- transplantation --- ischemia --- intestinal mucosa --- lung --- epithelia --- interleukin 13 --- UBE2Z --- ubiquitin --- osmolality --- hydrostatic pressure --- cancer --- sensor --- tricellular tight junctions --- endometrial cancer --- epithelial barrier dysfunction --- Claudin-7 --- permeability --- WNK4 --- epithelial sodium channel (ENaC), collecting duct cells --- claudin-1 --- hydrogen peroxide --- phosphorylation --- claudin --- angulin --- drug development --- angubindin-1 --- Clostridium perfringens enterotoxin --- Clostridium perfringens iota-toxin --- antibody --- Mz-ChA-1 cells --- biliary epithelial cells --- phosphatidylcholine --- mucus --- paracellular transport --- atopic dermatitis --- cytokines --- STAT3 --- ZO-2 --- cholestasis --- gene transcription --- hypertrophy --- tumor suppressor --- NLS --- NES --- CaSR --- RhoA --- barrier function --- paracellular permeability --- antidiuretic hormone --- Claudin-14 --- CLDN14 --- hearing loss --- vestibular function --- cochlear implantation --- Hepatitis C Virus --- viral entry --- epidermal barrier --- reconstructed human epidermis --- claudin targeting --- Campylobacter jejuni --- curcumin --- apoptosis --- co-culture --- mouse colon --- TNF --- NFκB --- lipolysis-stimulated lipoprotein receptor (LSR) --- epithelial barrier --- cell–cell contact --- caspase --- kidney stones --- ion reabsorption --- quercetin --- brain barriers --- blood-brain barrier --- neurovascular unit --- blood-cerebrospinal fluid barrier --- arachnoid barrier --- glia limitans --- adherens junctions --- paracellular sodium transport --- thick ascending limb --- nephropathy --- HELIX syndrome --- hypokalemia --- hypermagnesemia --- anhidrosis --- gland dysfunction --- aging --- blood–brain barrier --- mutations --- kidney --- liver --- skin --- human --- mice --- disease --- in silico --- drug discovery --- membrane proteins --- protein interactions --- molecular dynamics --- antibiotic-associated hemorrhagic colitis --- Klebsiella oxytoca --- tight junction assembly --- monocytes --- celiac disease --- claudin-2 --- epithelium --- inflammation --- fibrosis --- proliferation --- migration --- tricellular tight junction --- paracellular water transport --- tight epithelium --- MDCK C7 cells --- cell growth --- endothelia --- adherens junction --- apical junctional complex --- AMP-activated protein kinase (AMPK) --- paracellular barrier --- protein structure --- protein domain --- occludin --- junctional adhesion molecule --- zonula occludens --- MAGUK proteins --- PDZ domain --- stem cell --- chemoresistance --- retinal pigment epithelium --- retinopathy --- barrier formation --- collecting duct --- claudin-5 --- neuropathic pain --- nerve injury --- dorsal root ganglion --- enteropathogenic E. coli (EPEC) --- tight junctions (TJ) --- polarity --- atypical aPKCζ --- transepithelial electrical resistance (TER) --- sorting nexin 9 (SNX9) --- EspF --- claudin 1 --- tumor --- metastasis --- epithelial to mesenchymal transition --- cerebral cavernous malformation --- endothelial barrier --- Rho --- ROCK --- MEKK3 --- ion transport --- ion channel --- super-resolution microscopy --- structured illumination microscopy --- stimulated emission depletion --- single molecule localization microscopy --- Claudin --- blood-biliary barrier --- chronic liver disease --- hepatocellular carcinoma --- cholangiocellular carcinoma --- NISCH syndrome --- repair --- NHE2 --- ClC-2 --- inflammatory bowel disease --- mucosal immunology --- ZO-1 --- actomyosin --- aquaporin --- drinking rate --- epithelial fluid transport --- enterocyte --- osmoregulation --- paracellular --- proximal tubule --- calcium permeability --- claudin-12 --- paracellular channels and barriers --- cell polarity --- pathogens --- immune cells --- environmental sensors