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Impairment of orexin/hypocretin signaling causes narcolepsy-cataplexy in animals and humans. Most human narcolepsy-cataplexy cases are associated with orexin/hypocretin ligand deficiency, which can be detected clinically using cerebrospinal orexin/hypocretin measures and may lead to future treatments with orexin/hypocretin replacement therapy. In The Orexin/Hypocretin System: Physiology and Pathophysiology, leading researchers and clinicians review these exciting developments to set the stage for further research on the loss of orexin/hypocretin neurons in humans, regulation of sleep and wakefulness by the orexin/hypocretin system, and the role of the orexin/hypocretin system in many other physiological processes, including feeding, autonomic regulation, and neuroendocrine regulation. Topics of interest include an assessment of the functions and the physiology of orexin/hypocretin, its pathophysiology in human narcolepsy-cataplexy, and possible pharmacological treatments. The authors also introduce several experimental methods for orexin/hypocretin research, and, using multidisciplinary approaches, explain their uses and limitations. Authoritative and state-of-the-art, The Orexin/Hypocretin System: Physiology and Pathophysiology will aid scientists in the search for novel bioactive peptides and their receptors, as well as novel physiological insights and opportunities for the clinical treatment of not only narcolepsy, but also a broad range of diseases associated with endocrine, feeding, and body weight regulation.
Narcolepsy. --- Orexins. --- Orexins --- Narcolepsy --- Disorders of Excessive Somnolence --- Peptides --- Receptors, Neurotransmitter --- Receptors, Peptide --- Nerve Tissue Proteins --- Receptors, Cell Surface --- Amino Acids, Peptides, and Proteins --- Proteins --- Sleep Disorders, Intrinsic --- Chemicals and Drugs --- Membrane Proteins --- Dyssomnias --- Sleep Disorders --- Nervous System Diseases --- Mental Disorders --- Diseases --- Psychiatry and Psychology --- Neuropeptides --- Receptors, Neuropeptide --- Human Anatomy & Physiology --- Medicine --- Health & Biological Sciences --- Neurology --- Animal Biochemistry --- Hypocretins --- Medicine. --- Neurosciences. --- Biomedicine. --- Sleep disorders --- Hypothalamic hormones
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This interdisciplinary volume brings together many of the world’s leading clinicians and researchers to discuss current and anticipated developments in the understanding of narcolepsy. The volume is broadly divided into four main sections: Section I: Etiology; Section II: Clinical Considerations; Section III: Psychosocial considerations; and Section IV: Management. The areas covered include findings from research investigations on the genetic predisposition and pathophysiology, psychosocial aspects, and clinical management of narcolepsy by means of pharmacological and non-pharmacological methods. Special attention is paid to the translational aspects of narcolepsy. This volume is suitable for sleep disorders specialists and researchers, psychiatrists, neurologists, psychologists, social workers, behavioral scientists, graduate medical students, and any professionals and researchers interested in the interdisciplinary area of sleep medicine. Key Features · Focus on issues faced in day-to-day clinical settings – helps to inform and change clinical practice · Chapters address both clinical and research basis – highlights potential areas of future research · Interdisciplinary and translational approach – suitable for a wide range of clinicians and biomedical professionals Meeta Goswami, BDS, PhD, MPH, has been the director of the Narcolepsy Institute since its inception in 1985 and serves as an Assistant Professor of Neurology, Albert Einstein College of Medicine. Her general area of research interest includes narcolepsy and psychosocial issues. S.R. Pandi-Perumal, M.Sc, is the President and Chief Executive Officer of Somnogen Inc, a New York Corporation. He is a well-recognized sleep researcher both nationally and internationally, and has authored many publications. His general area of research interest includes sleep and biological rhythms. He is a well-known editor in the field of sleep medicine and has edited over 15 volumes dealing with various sleep-related topics. Michael J Thorpy, MD, has won many awards for his research including one of the sleep field's highest honors: the Nathaniel Kleitman Award. He is a well-published researcher and a board-certified sleep physician. He serves as a Professor of Neurology at Albert Einstein College of Medicine and the Director of the Sleep-Wake Disorders Center at Montefiore Medical Center, Bronx, New York.
Hypersomnia. --- Hypersomnolence, Idiopathic. --- Narcolepsy. --- Sleep disorders. --- Narcolepsy --- Disorders of Excessive Somnolence --- Sleep Disorders, Intrinsic --- Dyssomnias --- Sleep Disorders --- Nervous System Diseases --- Mental Disorders --- Diseases --- Psychiatry and Psychology --- Psychiatry --- Medicine --- Health & Biological Sciences --- Psychiatric Disorders, Individual --- Internal Medicine --- Disorders of sleep --- Medicine. --- General practice (Medicine). --- Obstetrics. --- Internal medicine. --- Geriatrics. --- Neurology. --- Pediatrics. --- Medicine & Public Health. --- Internal Medicine. --- General Practice / Family Medicine. --- Geriatrics/Gerontology. --- Obstetrics/Perinatology. --- Nervous system --- Psychology, Pathological --- Sleep disorders --- Family medicine. --- Obstetrics/Perinatology/Midwifery. --- Paediatrics --- Pediatric medicine --- Children --- Maternal-fetal medicine --- Gerontology --- Older people --- Family practice (Medicine) --- General practice (Medicine) --- Physicians (General practice) --- Medicine, Internal --- Neuropsychiatry --- Health and hygiene --- Neurology .
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Human Impact Assessment (HuIA) is a relatively new concept describing an integrated process that encompasses both Health Impact Assessment and Social Impact Assessment and is used to anticipate the effects of programs, projects and decisions on human health and welfare. Sleep occupies approximately one-third of our lives, but its human impact remains largely unrecognized. The prevalence of excessive sleepiness is recognized to be increasing in industrialized societies. Sleepiness and fatigue have high costs in terms of both lives lost and socioeconomic impact. Sleepiness and Human Impact Assessment provides a comprehensive exploration of many different facets of sleepiness in our 24-hour society from the new HuIA point of view. Among the covered issues are the physiology and pathophysiology of sleep, its relationship to daytime alertness, fatigue and drugs, the relevance of sleep-related fatigue in various occupational settings and public safety. This book will be of assistance to physicians, occupational health professionals, ergonomists, researchers and decision-makers as they strive to understand the full significance of sleepiness and to create a culture of accountability in everyday life without sleep-related risks. .
Drowsiness. --- Industrial safety. --- Sleep --- Psychological aspects. --- Sleeping --- Slumber --- Health --- Psychophysiology --- Rest --- Sleep-wake cycle --- Subconsciousness --- Dreams --- Hypnagogia --- Industrial accidents --- Industries --- Job safety --- Occupational hazards, Prevention of --- Occupational health and safety --- Occupational safety and health --- Prevention of industrial accidents --- Prevention of occupational hazards --- Safety, Industrial --- Safety engineering --- Safety measures --- Safety of workers --- Accidents --- System safety --- Sleepiness --- Somnolence --- Prevention --- Neurology. --- Neurosciences. --- Medicine. --- Public Health. --- Health Promotion and Disease Prevention. --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Neural sciences --- Neurological sciences --- Neuroscience --- Nervous system --- Medicine --- Neuropsychiatry --- Diseases --- Health Workforce --- Neurology . --- Public health. --- Health promotion. --- Health promotion programs --- Health promotion services --- Promotion of health --- Wellness programs --- Preventive health services --- Health education --- Community health --- Health services --- Hygiene, Public --- Hygiene, Social --- Public health services --- Public hygiene --- Social hygiene --- Human services --- Biosecurity --- Health literacy --- Medicine, Preventive --- National health services --- Sanitation
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Physiology of nerves and sense organs --- Pulmonary Disease (Specialty) --- Respiration Disorders --- Sleep Disorders --- Societies, Medical --- Sleep disorders --- Sleep --- Respiratory organs --- Troubles du sommeil --- Sommeil --- Appareil respiratoire --- Periodicals. --- Physiological aspects --- Periodicals --- Diseases --- Périodiques --- Aspect physiologique --- Maladies --- Respiration --- Respiration Disorders. --- Sleep Wake Disorders. --- Sommeil, Troubles du --- Respiration. --- Sleep. --- Sleep disorders. --- Diseases. --- Health Sciences --- Clinical Medicine --- General and Others --- sleep disorders. --- Disorders of sleep --- Nervous system --- Psychology, Pathological --- Respiratory diseases --- Sleeping --- Slumber --- Health --- Psychophysiology --- Rest --- Sleep-wake cycle --- Subconsciousness --- Dreams --- Hypnagogia --- Animal respiration --- Animals --- Breathing --- Ventilation (Physiology) --- Physiology --- Vital signs --- Aerobic exercises --- Breathing exercises --- insomnia --- behavior disorders --- nervous system diseases --- narcolepsy --- sleep deprivation --- somnolence --- Long Sleeper Syndrome --- Short Sleep Phenotype --- Short Sleeper Syndrome --- Sleep-Related Neurogenic Tachypnea --- Subwakefullness Syndrome --- Disorder, Sleep --- Disorder, Sleep Wake --- Disorders, Sleep --- Disorders, Sleep Wake --- Long Sleeper Syndromes --- Neurogenic Tachypnea, Sleep-Related --- Neurogenic Tachypneas, Sleep-Related --- Phenotype, Short Sleep --- Phenotypes, Short Sleep --- Short Sleep Phenotypes --- Short Sleeper Syndromes --- Sleep Disorder --- Sleep Phenotypes, Short --- Sleep Related Neurogenic Tachypnea --- Sleep Wake Disorder --- Sleep-Related Neurogenic Tachypneas --- Sleeper Syndrome, Long --- Sleeper Syndrome, Short --- Sleeper Syndromes, Long --- Sleeper Syndromes, Short --- Subwakefullness Syndromes --- Syndrome, Long Sleeper --- Syndrome, Short Sleeper --- Syndrome, Subwakefullness --- Syndromes, Long Sleeper --- Syndromes, Short Sleeper --- Syndromes, Subwakefullness --- Tachypnea, Sleep-Related Neurogenic --- Tachypneas, Sleep-Related Neurogenic --- Wake Disorder, Sleep --- Wake Disorders, Sleep --- Sleep Hygiene --- Disorder, Respiration --- Disorders, Respiration --- Respiration Disorder --- Air passages (Anatomy) --- Respiratory system --- Cardiopulmonary system
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