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"Thoroughly examines the influence of aberrant epigenetics during gametogenesis and embryogenesis, affecting parents, gametes and embryos, offspring and future generations Explores health outcomes for reproductive senescence, endocrine disruption, testicular cancer, prostrate cancer, breast cancer, ovarian, cancer, endometrial cancer and cervical cancers Features chapter contributions from international researchers in the field"--

Epigenetics.

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Epigenetic Gene Expression and Regulation reviews current knowledge on the heritable molecular mechanisms that regulate gene expression, contribute to disease susceptibility, and point to potential treatment in future therapies. The book shows how these heritable mechanisms allow individual cells to establish stable and unique patterns of gene expression that can be passed through cell divisions without DNA mutations, thereby establishing how different heritable patterns of gene regulation control cell differentiation and organogenesis, resulting in a distinct human organism with a variety of differing cellular functions and tissues. The work begins with basic biology, encompasses methods, cellular and tissue organization, topical issues in epigenetic evolution and environmental epigenesis, and lastly clinical disease discovery and treatment. Each highly illustrated chapter is organized to briefly summarize current research, provide appropriate pedagogical guidance, pertinent methods, relevant model organisms, and clinical examples. - Reviews current knowledge on the heritable molecular mechanisms that regulate gene expression, contribute to disease susceptibility, and point to potential treatment in future therapies - Helps readers understand how epigenetic marks are targeted, and to what extent transgenerational epigenetic changes are instilled and possibly passed onto offspring - Chapters are replete with clinical examples to empower the basic biology with translational significance - Offers more than 100 illustrations to distill key concepts and decipher complex science.

Epigenetics. --- Gene expression. --- Genetic regulation.

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Epigenetics. --- Environmental toxicology. --- Environmental health.

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Epigenetics of Cancer Prevention is the first to look at epigenetics and chemoprevention together. Although there is numerous scientific data available on how epigenetics can lead to cancer and how chemoprevention can be beneficial in the treatment of, or improvement of quality of life, together they will set an advanced understanding for the reader in this upcoming field of chemoprevention influencing epigenetics. This book discusses molecular epigenetic targets of natural products, such as green tea polyphenols, curcumin and resveratrol, and organ specific epigenetic targets related to diverse types of cancer, for example prostate, colorectal, breast, lung and skin cancers. Additionally, it encompasses a discussion on research methods and limitations to study epigenetics and epigenomics of chemopreventive drugs and personalized cancer treatment with phytochemicals. The book is ideal for cancer researchers, health care professionals and all individuals who are interested in cancer prevention research and its clinical applications, especially in natural remedies.--

Epigenetics. --- Cancer --- Neoplasms --- Epigenomics --- Prevention. --- prevention & control. --- methods.

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Epigenesis --- DNA --- Epigénèse --- ADN --- Periodicals. --- Methylation --- Periodicals --- Périodiques --- Méthylation --- Cell Differentiation. --- DNA Methylation. --- Epigenesis, Genetic. --- Gene Expression Regulation. --- Epigenetica. --- Methylation. --- Expression Regulation, Gene --- Regulation, Gene Action --- Regulation, Gene Expression --- Gene Action Regulation --- Regulation of Gene Expression --- Epigenetic Process --- Epigenetics Processes --- Epigenetic Processes --- Genetic Epigenesis --- Process, Epigenetic --- Processes, Epigenetic --- Processes, Epigenetics --- DNA Methylations --- Methylation, DNA --- Methylations, DNA --- Differentiation, Cell --- Cell Differentiations --- Differentiations, Cell --- Deoxyribonucleic acid --- Desoxyribonucleic acid --- Thymonucleic acid --- TNA (Nucleic acid) --- RNAi Therapeutics --- Gene Regulatory Networks --- DNA Methylation --- Methyl CpG Binding Domain --- Genomic Imprinting --- Gene Silencing --- Epigenesis, Genetic --- Embryo, Mammalian --- Gene Expression Regulation --- Cell Lineage --- Deoxyribose --- Nucleic acids --- Genes --- Embryology --- Evolution (Biology) --- Genetics --- Epigenesis. --- Life Sciences --- Zoology --- Epigenome