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This book reviews the structure-function relationship of nucleic acids, their role in the pathophysiology of the diseases, and as therapeutic targets for human diseases. The chapters discuss the role of nucleic acids in inflammatory diseases, neurodegenerative diseases, and cancer. The book also describes recent advancements in nucleic acid-based therapy, the application of nucleic acids in diagnostics, in the development of nano-carriers, logic gates, and sensors. It explores the use of nucleic acids (RNA and DNA) as a unique and multifunctional platform for numerous applications, including therapeutics, diagnostics, nanodevices, and materials. It further examines the role of DNA methylation, histone modifiers and readers, chromatin remodelers, microRNAs, and other components of chromatin in the progression of cancer. The book also discusses the applications of nucleic acid as a vaccine and as a gene-editing tool. It also provides an overview of the clinical trials using genome editing platforms for disease treatment and the challenges in implementing the editing technology. Finally, the book elucidates a representative description of challenges associated with nucleic acid-mediated therapy.

Genetics --- General biophysics --- Oncology. Neoplasms --- nucleïnezuren --- biologische materialen --- oncologie --- Diseases. --- Nucleic acids.

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General biochemistry --- Organic chemistry --- biochemie --- Didactics of biology --- Didactics of chemistry --- organische chemie --- biologie --- Biochemie --- Biochimie --- 485.42 --- Handboek/cursus --- biosynthese --- enzymen --- fotosynthese --- katalyse --- lipiden --- materie --- metabolisme --- nucleïnezuren --- oxidatie --- proteïnen --- sacchariden --- scheikunde --- water --- Biosynthese --- Eiwitten --- Elektronen --- Katalyse --- Koolhydraten --- Lipiden --- Macromoleculen --- Metabolisme --- Nucleïnezuren --- biotechnologie --- lipide --- suiker --- handboeken M.O. --- reeks Biochemie --- Scheikunde --- Biochimie--Manuels --- Biochemie--Handboeken --- handboeken M.O --- #BSCH: vak: biologie --- #BSCH: vak: wetenschappen --- Schoolbooks - Didactic material

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De toegenomen kennis van het menselijk genoom met de eventuele afwijkingen als mutaties, (gen)duplicaties en deleties n de mogelijkheid deze steeds betrouwbaarder op een gevalideerde manier aan te tonen, heeft de afgelopen jaren de moleculair-biologische technieken in toenemende mate tot een standaarduitrusting van moderne diagnostisch laboratoria gemaakt. In dit boek worden niet alleen d steeds breder wordende reeks toepassingen door deskundigen binnen het vakgebied besproken, maar is er ook aandacht voor de moleculair-biologische analysemethoden en de bijbehorende kwaliteitscontrole zelf.

General biochemistry --- Clinical chemistry --- biochemie --- Molecular biology --- moleculaire biologie --- Physical methods for diagnosis --- Genetica --- Medische analysen/Laboratoria --- Microbiologie --- Parasitologie --- Pathologie --- 57.089 --- 577.1 --- biologie --- diagnostiek --- genoom --- laboratoriumtechnieken --- moleculaire diagnostiek --- nucleïnezuren --- 577.2 --- Analyse (klinische biologie) --- Moleculaire biologie --- Génétique --- Analyses médicales/Laboratoires --- .chemische basis van leven. biochemie en bio-organische chemie in het algemeen --- klinische chemie

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This book presents an overview over the diverse functions RNA plays in fungal biology, highlighting the latest state of knowledge, as well as remaining questions and future challenges in this area. It covers a wide range of RNA-mediated biological mechanisms in yeasts and filamentous fungi, including organisms widely used as models for general aspects of eukaryotic biology, and of great importance in industrial applications, medicine and agriculture. Despite the diversity of the estimated 1 million fungal species (saprophytic, parasitic and mutualistic), fungi share common features distinctive from plants and animals and have been grouped taxonomically as an independent eukaryotic kingdom. In this book, 15 chapters written by experts in their fields cover the RNA-dependent processes that take place in fungal cells ranging from formation of coding and non-coding RNAs to mRNA translation, ribosomal RNA biogenesis, gene silencing, RNA editing and epigenetic regulation.

Organic chemistry --- Genetics --- General microbiology --- Molecular biology --- Biology --- Biotechnology --- gisten --- RNA (ribonucleic acid) --- nucleïnezuren --- organische chemie --- biologie --- microbiologie --- biotechnologie --- genetische manipulatie --- DNA (deoxyribonucleic acid) --- moleculaire biologie --- genexpressie --- Nucleic acids. --- Gene expression. --- Biological models. --- Microbiology. --- Nucleic Acid Chemistry. --- Gene Expression. --- Systems Biology. --- Eukaryotic Microbiology. --- Genes --- Genetic regulation --- Polynucleotides --- Biomolecules --- Microbial biology --- Microorganisms --- Models, Biological --- Expression --- Systems biology. --- Computational biology --- Bioinformatics --- Biological systems

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Chemical laboratory practice --- Analytical biochemistry --- Biochemistry --- 577.1 --- Biochemie --- 543.64 --- 57.088 --- aminozuren --- analyse --- analytische biochemie --- analytische chemie (scheikunde) --- antistoffen --- biochemie --- biologie --- biomoleculen --- centrifugeren --- chromatografie --- databases --- elektroforese --- enzymen --- isotopen --- kinetica --- koolhydraten --- laboratoriumbiochemie --- laboratoriumbiologie --- lipiden --- membranen --- metabolisme --- nucleïnezuren --- plasmiden --- proteïnen --- radiochemie --- spectrofotometrie --- transformaties --- vectoren