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Histology. Cytology --- CRISPR (Genetics) --- Genetics --- Clustered Regularly Interspaced Short Palindromic Repeats. --- Gene Editing. --- Genetic Research. --- Research --- Moral and ethical aspects --- Moral and ethical aspects. --- Research. --- Research, Genetic --- Genome Editing --- Base Editing --- Editing, Base --- Editing, Gene --- Editing, Genome --- CRISPR-Associated Protein 9 --- Mutagenesis, Site-Directed --- CRISPR-Cas Systems --- CRISPR Arrays --- CRISPR Clusters --- CRISPR Elements --- CRISPR Loci --- CRISPR Locus --- CRISPR Sequences --- CRISPR Spacer Sequences --- CRISPR Spacers --- CRISPR-Cas Loci --- CRISPRs --- Clustered Regularly Interspaced Short Palindromic Repeat --- Array, CRISPR --- Arrays, CRISPR --- CRISPR --- CRISPR Array --- CRISPR Cas Loci --- CRISPR Cluster --- CRISPR Element --- CRISPR Sequence --- CRISPR Spacer --- CRISPR Spacer Sequence --- CRISPR-Cas Locus --- Cluster, CRISPR --- Clusters, CRISPR --- Element, CRISPR --- Elements, CRISPR --- Loci, CRISPR --- Loci, CRISPR-Cas --- Locus, CRISPR --- Locus, CRISPR-Cas --- Sequence, CRISPR --- Sequence, CRISPR Spacer --- Sequences, CRISPR --- Sequences, CRISPR Spacer --- Spacer Sequence, CRISPR --- Spacer Sequences, CRISPR --- Spacer, CRISPR --- Spacers, CRISPR --- CRISPR-Associated Proteins --- Genetic research --- Biology --- Embryology --- Mendel's law --- Adaptation (Biology) --- Breeding --- Chromosomes --- Heredity --- Mutation (Biology) --- Variation (Biology) --- Clustered Regularly Interspaced Short Palindromic Repeats (Genetics) --- Immunogenetics --- Nucleotide sequence

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RNA interference (RNAi) is a widely used technology for gene silencing and has become a key tool in a myriad of research and lead discoveries. In recent years, the mechanism of RNAi agents has been well investigated, and the technique has been optimized for better effectiveness and safety. On the other hand, the clustered regularly interspaced short palindromic repeats (CRISPR)-associated Cas9/gRNA system is a recent, novel, targeted genome-editing technique derived from the bacterial immune system. Recent advances in gene-editing research and technologies have enabled the CRISPR Cas9 system to become a popular tool for sequence-specific gene editing to correct and modify eukaryotic systems. In this book, we will focus on the mechanisms, applications, regulations (their pros and cons), and various ways in which RNAi-based methods and CRIPSR-Cas9 technology have stimulated the modulation of gene expression, thereby making them a promising therapeutic tool to treat and prevent complex diseases and disorders.

CRISPR-associated protein 9. --- Cas9 (CRISPR-associated protein 9) --- CRISPR/Cas9 --- Endonucleases --- Gene editing --- Life Sciences --- Molecular Genetics --- Genetics and Molecular Biology --- Genomics --- Biochemistry

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Genome Editing: A Practical Guide to Research and Clinical Applications is geared towards investigators interested in learning how to use CRISPR-Cas9-based technologies, with a focus on cardiovascular research and clinical applications. Covering a range of topics from the basics of genome editing to design considerations, to assessments and applications, this reference allows readers to get started and establish a full workflow from the beginning of the project to its full completion. With worked examples drawn from real-life experiments, as well as troubleshooting and pitfalls to avoid, the book serves as an essential reference for researchers and investigators in both cardiovascular and biomedical research.

Gene editing. --- CRISPR-associated protein 9. --- CRISPR (Genetics). --- Cardiovascular system --- Diseases --- Genetic aspects. --- Circulatory system --- Vascular system --- Blood --- Clustered Regularly Interspaced Short Palindromic Repeats (Genetics) --- Immunogenetics --- Nucleotide sequence --- Cas9 (CRISPR-associated protein 9) --- CRISPR/Cas9 --- Endonucleases --- Gene editing --- Editing, Gene --- Editing, Genome --- Genome editing --- Genetic engineering --- Circulation --- Methodology.

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Human genetics. --- CRISPR (Genetics) --- Clustered Regularly Interspaced Short Palindromic Repeats (Genetics) --- Immunogenetics --- Nucleotide sequence --- Genetics --- Heredity, Human --- Human biology --- Physical anthropology --- ADN --- Genètica humana

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This book is open access under a CC BY 4.0 license. Innovations in molecular biology are allowing neuroscientists to study the brain with unprecedented resolution, from the level of single molecules to integrated gene circuits. Chief among these innovations is the CRISPR-Cas genome editing technology, which has the precision and scalability to tackle the complexity of the brain. This Colloque Médecine et Recherche has brought together experts from around the world that are applying genome editing to address important challenges in neuroscience, including basic biology in model organisms that has the power to reveal systems-level insight into how the nervous system develops and functions as well as research focused on understanding and treating human neurological disorders.

Medicine. --- Human genetics. --- Neurosciences. --- Biomedical engineering. --- Biomedicine. --- Human Genetics. --- Biomedical Engineering/Biotechnology. --- Gene editing. --- Editing, Gene --- Editing, Genome --- Genome editing --- Neural sciences --- Neurological sciences --- Neuroscience --- Medical sciences --- Nervous system --- Genetics --- Heredity, Human --- Human biology --- Physical anthropology --- Clinical engineering --- Medical engineering --- Bioengineering --- Biophysics --- Engineering --- Medicine --- Clinical sciences --- Medical profession --- Life sciences --- Pathology --- Physicians --- CRISPR --- muscular dystrophy --- Parkinson's disease --- DNA --- Rett syndrome --- double-strand breaks --- Huntington's disease --- genetic engineering