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Major depressive disorder (MDD) is a complex and heterogeneous disorder, phenotypically and biologically. MDD may be caused by complex interaction between genes and environment in susceptible individuals. Thus, a combination of certain genetic polymorphism, environmental stress, and personal susceptibility ultimately may induce MDD. Gene-environment interactions in the pathophysiology of MDD lead to advancement in personalized medicine by means of genotyping for inter-individual variability in drug action and metabolism. Gene-environment interactions may explain why some subjects become depressed while others remain unaffected. The aim of this book is to describe current knowledge of MDD from the point of view of neurobiology, molecular genetics and cognition. The authors address a deep understanding of cognitive and neurobiological mechanisms involved in MDD.

Depression, Mental --- Psychological aspects --- Dejection --- Depression, Unipolar --- Depressive disorder --- Depressive psychoses --- Melancholia --- Mental depression --- Unipolar depression --- Affective disorders --- Neurasthenia --- Neuroses --- Manic-depressive illness --- Melancholy --- Sadness --- Neurosciences --- Bipolar disorder

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Current research on depression argues that depression should no longer be viewed as a sigular psychiatric disorder but comorbid with other disorders and diseases. The Nature of Depression: An Updated Review provides clear connections between psychiatric and neurological disorders. Unlike prior books on depression, this book covers many neurological and psychiatric disorders, including Parkinson's disease, major depressive disorder, Alzheimer's disease, PTSD, addiction and anxiety disorder. In addition, this book covers different forms of depression, including transition-induced depression and the development of depression following major life events, including birth of a child, menopause and retirement. Key Features: Covers depression comorbidity with psychological and neurological disorders ; Reviews comorbidity with addiction, anxiety, trauma and psychosis ; Compares the symptoms of subclinical depression to major depression ; Discusses how stress and sleep impact depression ; Theorizes the path of depression following negative life transitions.--Publisher website.

Depression, Mental. --- Depression. --- Dejection --- Depression, Unipolar --- Depressive disorder --- Depressive psychoses --- Melancholia --- Mental depression --- Unipolar depression --- Affective disorders --- Neurasthenia --- Neuroses --- Manic-depressive illness --- Melancholy --- Sadness --- Bipolar disorder

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A User's Guide to Melancholy takes Robert Burton's encyclopaedic masterpiece The Anatomy of Melancholy (first published in 1621) as a guide to one of the most perplexing, elusive, attractive, and afflicting diseases of the Renaissance. Burton's Anatomy is perhaps the largest, strangest, and most unwieldy self-help book ever written. Engaging with the rich cultural and literary framework of melancholy, this book traces its causes, symptoms, and cures through Burton's writing. Each chapter starts with a case study of melancholy - from the man who was afraid to urinate in case he drowned his town to the girl who purged a live eel - as a way into exploring the many facets of this mental affliction. A User's Guide to Melancholy presents in an accessible and illustrated format the colourful variety of Renaissance melancholy, and contributes to contemporary discussions about wellbeing by revealing the earlier history of mental health conditions.

Depression, Mental. --- Dejection --- Depression, Unipolar --- Depressive disorder --- Depressive psychoses --- Melancholia --- Mental depression --- Unipolar depression --- Affective disorders --- Neurasthenia --- Neuroses --- Manic-depressive illness --- Melancholy --- Sadness --- Burton, Robert, --- Bipolar disorder

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Psychiatry --- Anxiety --- Depression --- Helplessness (Psychology) --- Depression, Mental --- Dépression --- Depression, Mental. --- Helplessness (Psychology). --- Dépression --- Anxiety. --- Emotions --- Dejection --- Depression, Unipolar --- Depressive disorder --- Depressive psychoses --- Melancholia --- Mental depression --- Unipolar depression --- Affective disorders --- Neurasthenia --- Neuroses --- Manic-depressive illness --- Melancholy --- Sadness --- Depression. --- Bipolar disorder

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Depression, Mental --- Congresses --- -Dejection --- Depression, Unipolar --- Depressive disorder --- Depressive psychoses --- Melancholia --- Mental depression --- Unipolar depression --- Affective disorders --- Neurasthenia --- Neuroses --- Manic-depressive illness --- Melancholy --- Sadness --- Depression. --- Congresses. --- -Congresses --- Depression, Mental - Congresses