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Materials science and engineering are strongly developing tools with increasing impact in the biotechnological and biomedical areas. Interestingly, research in molecular and cellular biology is often at the core of the design and development of materials-based approaches, providing biological rationale. Focused on research relying on biology–materials interaction, IJMS launched a Special Issue named “Cells and Materials for Disease Modeling and Regenerative Medicine”. The aim of the Special Issue was to generate a compilation of in vitro and in vivo strategies based on cell–material interactions. This book compiles the papers published in that Special Issue and includes a selection of six original scientific experimental articles and six comprehensive reviews. We are convinced that this collection of articles shows representative examples of the state of the art in the field, unveiling the relevance of materials research in generating new regenerative medicine and disease modeling approaches.

Research & information: general --- Leigh syndrome --- mitochondrial disorder --- iPSC --- NSC --- neuron --- disease modeling --- mtDNA --- high hydrostatic pressure --- devitalization --- decellularization --- allografts --- regenerative medicine --- bone and cartilage regeneration --- dentogenesis --- amelogenesis --- dentinogenesis --- cementogenesis --- drug release materials --- scaffolds --- odontogenic cells --- stem cells --- whole-tooth regeneration --- psoriasis --- cyclic adenosine monophosphate --- cholera toxin --- isoproterenol --- tissue engineering --- extracellular matrix --- collagen --- elastin --- bladder --- compliance --- microarchitecture --- biomimicry --- blood cancer --- bone marrow --- niche --- microenvironment --- 3D models --- tumor-on-a-chip --- leukemia --- myeloma --- biomaterials --- cytokines --- growth factors --- cardiac tissue regeneration --- adipose tissue --- fibrosis --- in vitro models --- in vivo models --- dental pulp stem cells --- osteogenesis --- rheumatoid arthritis --- mesenchymal stromal cells --- co-culture --- 3D cell culture --- explants --- joint-on-a-chip --- piezoelectric --- electroactive --- patterning --- cell differentiation --- bone tissue engineering

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The Book covers this whole field, from the discovery of structurally new and bioactive natural products (including biomacromolecules), from marine macro-/micro-organisms, to the pharmacodynamics, pharmacokinetics, metabolisms, and mechanisms of marine-derived lead compounds, both in vitro and in vivo, along with the synthesis and/or structural optimization of marine-derived lead compounds and their structure–activity relationships. Taken together, this Special Issue reprint not only provides inspiration for the discovery of marine-derived novel bioactive compounds, but also sheds light on the further research and development of marine candidate drugs.

Medicine --- Antarctic krill (Euphausia superba) --- peptide --- antioxidant activity --- stability --- oyster --- plasma --- peptidome --- antimicrobial peptides --- cytotoxicity --- actinomycete --- piericidins --- absolute configuration --- Pestalotiopsis heterocornis --- heterocornols --- anti-inflammatory activity --- sponge-derived fungus --- sclerotides --- lipodepsipeptide --- Aspergillus sclerotiorum --- nasopharyngeal carcinoma --- AChE inhibitory --- vascular endothelial cell --- flavonoid --- oxidized low-density lipoprotein --- Nrf2 --- apoptosis --- butyrolactone I --- food allergy --- metabolism --- pharmacokinetics --- actinomycin X2 --- microbial pigments --- dyeing --- silk --- antibacterial properties --- PD-L1 --- virtual screening --- pharmacophore modeling --- ADME --- molecular dynamics --- xanthones --- ascidian-derived fungus --- Diaporthe sp. --- anti-glioma activity --- antiaging --- Sonneratia apetala --- signaling pathway --- Caenorhabditis elegans --- mutants --- coral-derived fungi --- Aspergillus hiratsukae --- meroterpenoids --- antibacterial activity --- cytotoxic activity --- deep-sea-derived fungus --- Aspergillus puniceus --- isoquinoline alkaloid --- protein tyrosine phosphatase inhibitor --- antibacterial --- Aspergillus sp. --- geodin --- semisynthesize --- insecticidal activity --- Arca inflata --- antitumor peptide --- MAPK signaling --- calmodulin --- colorectal cancer --- methicillin-resistant Staphylococcus aureus --- actinomycin D --- Streptomyces parvulus --- mechanism --- mangrove endophytic Pestalotiopsis --- Sdy-1 --- antitumor activity --- Wnt signaling --- β-catenin --- eremophilane sesquiterpenoids --- mangrove-derived fungus --- Penicillium sp. --- Oceanapia --- sponge --- secondary metabolites --- biological activities --- drug design --- anticancer --- cyclic pentapeptide --- galaxamide analogues --- skipjack tuna (Katsuwonus pelamis) muscle --- angiotensin-I-converting enzyme (ACE) peptide --- molecular docking --- nitric oxide (NO) --- endothelin-1 (ET-1) --- Trichoderma longibrachiatum --- sesquiterpene glycoside --- antimicrobial activity --- marine fungi --- Aspergillus unguis --- depsides --- depsidones --- osteoclast differentiation --- soft-coral-derived fungus --- pyranodipyran derivatives --- tyrosyl DNA phosphodiesterase 1 inhibitory activities --- fluorescent properties --- butenolides --- enantiomers --- Aspergillus terreus --- pancreatic lipase --- NAFLD --- fucoxanthin --- adenosine monophosphate-activated protein kinase (AMPK) --- nuclear factor erythroid-2-related factor 2-mediated (Nrf2) --- Toll-like receptor 4-mediated (TLR4) --- Aspergillus flavipes HN4-13 --- emodin --- macroporous resin XAD-16 --- adsorption kinetics and isotherms --- enrichment --- tetramic acid derivatives --- deep-sea fungus --- clavipitacae --- Lecanicillium fusisporum --- chronic kidney disease --- fucoidan --- cognitive dysfunction --- neuroinflammation --- oxidative stress --- GSK3β-Nrf2-HO-1 signaling --- microglial polarization --- deep-sea actinomycetes --- aromatic acids --- oximes --- antihyperlipidemic --- phycocyanin --- microbiota --- transcriptome --- IL-17 pathway --- Hahella --- prodiginine --- chejuenlide --- genome mining --- LC-MS/MS --- CDK4/6 --- marine compounds --- pharmacophore construction --- ADMET --- mm-pbsa