Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Annotation Bridging cellular membranes is a key step in the pathogenic action of both binary and pore-forming bacterial toxins. The former use their translocation domains, containing various structural motifs, to ensure efficient delivery of the toxic component into the host cell, while the latter act on the cellular membrane itself. In either case, the integrity of the membrane is compromised via targeted protein-lipid and protein-protein interactions triggered by specific signals, such as proteolytic cleavage or endosomal acidification. This Special Issue presents recent advances in characterizing functional, structural and thermodynamic aspects of the conformational switching and membrane interactions involved in the cellular entry of bacterial protein toxins. Deciphering the physicochemical principles underlying these processes is also a prerequisite for the use of protein engineering to develop toxin-based molecular vehicles capable of targeted delivery of therapeutic agents to tumors and other diseased tissues.

Bacterial toxins.

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Annotation The special issue "Enterotoxins: Microbial Proteins and Host Cell Dysregulation" is comprised of research articles and reviews covering a diverse group of toxins that affect the gut and dysregulate host immune response in mechanistically different ways. Excellent in-depth reviews of staphylococcal superantigens and Clostridium perfringens toxins are the cornerstones of this issue. The present editorial highlights these papers grouped by toxin class and, within each toxin class, papers are discussed in order of publication date, with reviews appearing first, followed by original articles.

Enterotoxins. --- Enterotoxin --- Bacterial toxins

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Bacterial toxins --- Bacillus thuringiensis --- Analysis

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Bacteria. --- Toxins --- Bacterial toxins --- Toxines bactériennes

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Bacterial Toxins --- Cell Membrane --- Bacterial toxins --- Cell membranes --- Toxines bactériennes --- Membrane cellulaire --- Bacterial Toxins. --- Cell Membrane. --- Cell surfaces --- Cytoplasmic membranes --- Plasma membranes --- Plasmalemma --- Membranes (Biology) --- Bacterial antigens --- Microbial toxins --- Cytoplasmic Membrane --- Plasma Membrane --- Cell Membranes --- Cytoplasmic Membranes --- Membrane, Cell --- Membrane, Cytoplasmic --- Membrane, Plasma --- Membranes, Cell --- Membranes, Cytoplasmic --- Membranes, Plasma --- Plasma Membranes --- Membranes --- Toxins, Bacterial --- Bacterial toxins. --- Cell membranes. --- Toxines bactériennes --- Glycocalyces --- Bacterial Toxin --- Toxin, Bacterial