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The discovery and development of a biological active molecule with therapeutic properties is an ever increasing complex task, highly unpredictable at the early stages and marked, in the end, by high rates of failure. As a consequence, the overall process leading to the production of a successful drug is very costly. The improvement of the net outcome in drug discovery and development would require, amongst other important factors, a good understanding of the molecular events that characterize the disease or pathology in order to better identify likely targets of interest, to optimize the interaction of an active agent (small molecule or macromolecule of natural or synthetic origin) with those targets, and to facilitate the study of the pharmacokinetics, pharmacodynamics and toxicity of an active agent in suitable models and in human subjects. The objective of this Research Topic is to highlight new developments and applications of imaging techniques with the objective of performing pharmacological studies in vivo, in animal models and in humans. In the domain of drug discovery, the pharmacological and biomedical questions constitute the center of attention. In this sense, it is fundamental to keep in mind the strengths and limitations of each analytical or imaging technique. At the end, the judicious application of the technique with the aim of supporting the search for answers to manifold questions arising during a long and painstaking path provides a continuous role for imaging within the complex area of drug discovery and development.

magnetic resonance imaging (MRI) --- computerized tomography(CT) --- positron emission tomography (PET) --- pharmacology --- single photon emission computed tomography (SPECT) --- imaging --- medical imaging --- ultrasound

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The x-ray computed tomography (CT) is well known as a useful imaging method and thus CT images have continuingly been used for many applications, especially in medical fields. This book discloses recent advances and new ideas in theories and applications for CT imaging and its analysis. The 16 chapters selected in this book cover not only the major topics of CT imaging and analysis in medical fields, but also some advanced applications for forensic and industrial purposes. These chapters propose state-of-the-art approaches and cutting-edge research results.

Tomography. --- Body section radiography --- Computed tomography --- Computer tomography --- Computerized tomography --- CT (Computed tomography) --- Laminagraphy --- Laminography --- Radiological stratigraphy --- Stratigraphy, Radiological --- Tomographic imaging --- Zonography --- Cross-sectional imaging --- Radiography, Medical --- Geometric tomography --- Radiology

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The advent and rapid diffusion of advanced multidetector-row scanner technology offers comprehensive evaluation of different anatomic structures in daily practice. The aim of this book is to introduce the applications of CT imaging in not only general medicine but also in different fields especially in veterinary medicine, dentistry, and engineering. Recent developments in CT technology have led to a widening of its applications on many areas like material testing in engineering, 3D evaluation of teeth, and the vascular and cardiac evaluations of small animals.

Tomography. --- Body section radiography --- Computed tomography --- Computer tomography --- Computerized tomography --- CT (Computed tomography) --- Laminagraphy --- Laminography --- Radiological stratigraphy --- Stratigraphy, Radiological --- Tomographic imaging --- Zonography --- Cross-sectional imaging --- Radiography, Medical --- Geometric tomography --- Medicine --- Diagnostics --- Radiology Diagnosis --- Health Sciences

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The overall goal of this book is to promote research and development of imaging and radioanalytical techniques by publishing high-quality chapters in this rapidly growing interdisciplinary field. This book discusses the principles and applications of imaging and radioanalytical techniques across a wide spectrum of interdisciplinary science, technology and medicine, where these techniques are expected to make significant difference and contribution. It also explores the history of the field, current trends, and future directions. The book focuses mainly on cutting-edge applications, and associated equipments and methods, such as instrumentation systems and computing hardware/software. The primary target audience for this book includes students, researchers, clinicians, and professionals who are interested in medical and ground penetrating radar (GPR) imaging, and radioanalytical techniques.

Tomography. --- Body section radiography --- Computed tomography --- Computer tomography --- Computerized tomography --- CT (Computed tomography) --- Laminagraphy --- Laminography --- Radiological stratigraphy --- Stratigraphy, Radiological --- Tomographic imaging --- Zonography --- Cross-sectional imaging --- Radiography, Medical --- Geometric tomography --- Medical imaging

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This edited volume will focus on the advanced elements of computed tomography for an array of audiences, but more specifically, to undergraduate and postgraduate radiographers or CT technologists. This book will draw on the international expertise of advanced topics in CT. Typically, CT practices and approaches differ between hospital sites and workplace environments. As there are currently no universally accepted approaches, the reader can use this book to develop local imaging protocols with adjustments made for patients, the type of scanner and the radiologists’ or physicians’ preferences. Editors anticipate this to remain a key text for undergraduate and postgraduate radiography and CT students as it incorporates a holistic view of the profession whilst identifying advanced knowledge and understanding pertinent to CT practice. This is not a text on CT physics and imaging protocols alone but on the application and potential for such advanced techniques within the computed tomography field. The text, which includes most relevant technical and pathophysiological premises, also articulates learning points and pitfalls. Throughout the text, there is also an emphasis on image evaluation, with guidance on the recognition of normal, benign, and malignant pathologies and clear instruction on learning points and pitfalls. Given the increasing recognition of advanced scope of practice and professional capabilities in the field of medical radiation science, a focus on CT imaging within emergency settings, interventional environments and forensic imaging is portrayed. It is intended that this text will enhance and offer original discussions surrounding the interconnectivity of the technology, sciences research, and patient care in CT.

Radiology. --- Radiological physics --- Physics --- Radiation --- Tomography. --- Body section radiography --- Computed tomography --- Computer tomography --- Computerized tomography --- CT (Computed tomography) --- Laminagraphy --- Laminography --- Radiological stratigraphy --- Stratigraphy, Radiological --- Tomographic imaging --- Zonography --- Cross-sectional imaging --- Radiography, Medical --- Geometric tomography