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Blood-brain barrier. --- Blood-cerebral barrier --- Blood-cerebrospinal fluid barrier --- Brain-blood barrier --- Hemato-encephalic barrier --- Hematoencephalic barrier --- Brain --- Cerebrospinal fluid --- Choroid plexus --- Blood-vessels --- Barrera hematoencefàlica --- Farmacologia
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This Special Issue of Pharmaceutics, "Advanced Blood-Brain Barrier Drug Delivery," comprises 16 articles or reviews, which cover a cross-section of brain drug delivery for either small-molecule or large-molecule therapeutics.
Blood-brain barrier. --- Blood-cerebral barrier --- Blood-cerebrospinal fluid barrier --- Brain-blood barrier --- Hemato-encephalic barrier --- Hematoencephalic barrier --- Brain --- Cerebrospinal fluid --- Choroid plexus --- Blood-vessels
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Neutrophils regulate immune responses during homeostasis as well as disease pathogenesis. Especially, the neutrophils extracellular traps largely contribute to necroinflammation. This book highlights the role of neutrophils and neutrophils extracellular traps in various sterile and non-sterile, acute and chronic inflammatory conditions affecting both human and animal health.
Medicine --- head-and-neck cancer --- metastasis --- neutrophils --- NETs --- NETosis --- innate immunity --- G-CSF --- neutrophils extracellular traps --- ophthalmology --- diseases --- neutrophil extracellular traps (NETs) --- Alzheimer’s disease --- multiple sclerosis --- ischemic stroke --- meningitis --- central nervous system --- brain --- neurons --- brain–blood barrier --- equine recurrent uveitis --- horse --- cathelicidin --- neutrophil extracellular traps --- Candida albicans --- quorum sensing --- farnesol --- cerebrospinal fluid --- adults --- children --- infection --- chemokines --- cytokines --- borrelia --- virus --- hemozoin --- plasma --- fibrinogen --- platelet --- malaria --- NLRP3 inflammasome --- IL-1β --- cardiovascular disease --- inflammation --- diabetes --- obesity --- liver injury --- neutrophil extracellular trap --- myeloperoxidase --- carbon tetrachloride --- autoimmunity --- autoimmune diseases --- autoantigens --- SARS-CoV-2 --- coronavirus --- complement --- thrombosis --- MERS-CoV --- necroinflammation --- periodontitis --- neutrophil functions --- n/a --- Alzheimer's disease --- brain-blood barrier
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Blood-brain barrier. --- Biological transport. --- Molecular neurobiology. --- Molecular neurology --- Nervous system --- Molecular biology --- Neurobiology --- Membrane transport --- Passive transport, Biological --- Physiological transport --- Transport, Biological --- Diffusion --- Osmosis --- Blood-cerebral barrier --- Blood-cerebrospinal fluid barrier --- Brain-blood barrier --- Hemato-encephalic barrier --- Hematoencephalic barrier --- Brain --- Cerebrospinal fluid --- Choroid plexus --- Molecular aspects --- Blood-vessels --- Neurosciences. --- Neural sciences --- Neurological sciences --- Neuroscience --- Medical sciences
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Vascular Mechanisms in CNS Trauma focuses on the vascular aspects of brain and spinal cord trauma. Twenty nine chapters are arranged in three sections—Molecular Mechanisms; Experimental Models and Methods; and Clinical Challenges and Opportunities. The first section addresses topics in the basic biology of brain and spinal cord trauma, ranging from the pathophysiology of cerebral endothelial cells and gliovascular interactions to the role of stem cells in neurovascular repair. The second section covers experimental methods in rodent and in large animal models of CNS injury, as well as the use of biomaterials and biomarkers in studying the mechanisms of tissue response. The third section deals with clinical issues in the monitoring and treatment of the patient with traumatic injury of the brain and spinal cord. Contributors to the book include an integrated mix of basic scientists and clinicians from diverse institutions. By presenting salient issues in CNS trauma from a vascular perspective, this book should make a unique contribution to the understanding of traumatic brain and spinal cord injury.
Blood-brain barrier. --- Central nervous system. --- Nervous system, Central --- Blood-cerebral barrier --- Blood-cerebrospinal fluid barrier --- Brain-blood barrier --- Hemato-encephalic barrier --- Hematoencephalic barrier --- Neurosciences. --- Neurology. --- Neurobiology. --- Nervous system --- Brain --- Cerebrospinal fluid --- Choroid plexus --- Blood-vessels --- Neurosciences --- Medicine --- Neuropsychiatry --- Neural sciences --- Neurological sciences --- Neuroscience --- Medical sciences --- Diseases --- Neurology .
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Medicinal chemistry is both science and art. The science of medicinal chemistry offers mankind one of its best hopes for improving the quality of life. The art of medicinal chemistry continues to challenge its practitioners with the need for both intuition and experience to discover new drugs. Hence sharing the experience of drug research is uniquely beneficial to the field of medicinal chemistry. Drug research requires interdisciplinary team-work at the interface between chemistry, biology and medicine. Therefore, the topic-related series Topics in Medicinal Chemistry covers all relevant aspects of drug research, e.g. pathobiochemistry of diseases, identification and validation of (emerging) drug targets, structural biology, drugability of targets, drug design approaches, chemogenomics, synthetic chemistry including combinatorial methods, bioorganic chemistry, natural compounds, high-throughput screening, pharmacological in vitro and in vivo investigations, drug-receptor interactions on the molecular level, structure-activity relationships, drug absorption, distribution, metabolism, elimination, toxicology and pharmacogenomics. In general, special volumes are edited by well known guest editors.
Blood-brain barrier. --- Blood-cerebral barrier --- Blood-cerebrospinal fluid barrier --- Brain-blood barrier --- Hemato-encephalic barrier --- Hematoencephalic barrier --- Brain --- Cerebrospinal fluid --- Choroid plexus --- Blood-vessels --- Biochemistry. --- Medicine. --- Toxicology. --- Medicinal Chemistry. --- Molecular Medicine. --- Pharmacology/Toxicology. --- Chemicals --- Medicine --- Pharmacology --- Poisoning --- Poisons --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Chemistry --- Toxicology --- Composition --- Health Workforce --- Medicinal chemistry. --- Molecular biology. --- Pharmacology. --- Drug effects --- Medical pharmacology --- Chemotherapy --- Drugs --- Pharmacy --- Molecular biochemistry --- Molecular biophysics --- Biochemistry --- Biophysics --- Biomolecules --- Systems biology --- Chemistry, Medical and pharmaceutical --- Chemistry, Pharmaceutical --- Drug chemistry --- Medical chemistry --- Medicinal chemistry --- Pharmacochemistry --- Physiological effect
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This book was written by many outstanding investigators who have spent decades to study different aspects of blood‑tissue barrier function. They have summarized some of the latest and fascinating development in their fields of research including the blood‑brain barrier, the blood‑retinal barrier, the gut barrier, the blood‑biliary barrier, the blood‑follicle barrier, the blood‑epididymis barrier, the blood‑testis barrier, the tight junction barrier in general as well as barriers in the female reproductive tract. Included are also chapters that focus on topics that are physiologically applicable to all blood‑tissue barriers. Many of these chapters also include information on specific human diseases, such as pathological changes of the gut barrier that cause bowel disorders resulting from inflammation of the epithelial lining in the intestine, and infertility in men as a result of disruption of the blood‑epididymal and/or blood‑testis barriers; and on new therapeutic approaches (e.g., drug delivery across the blood‑brain and the blood‑retinal barriers).
Blood-air barrier. --- Blood-brain barrier. --- Capillaries -- Permeability. --- Capillary permeability. --- Blood-brain barrier --- Capillaries --- Cardiovascular Physiological Phenomena --- Retina --- Seminiferous Tubules --- Pulmonary Alveoli --- Cardiovascular System --- Biological Transport --- Brain --- Anatomy --- Testis --- Central Nervous System --- Lung --- Eye --- Circulatory and Respiratory Physiological Phenomena --- Metabolism --- Respiratory System --- Sense Organs --- Metabolic Phenomena --- Phenomena and Processes --- Nervous System --- Genitalia, Male --- Genitalia --- Urogenital System --- Blood-Air Barrier --- Blood-Brain Barrier --- Blood-Testis Barrier --- Capillary Permeability --- Blood-Retinal Barrier --- Human Anatomy & Physiology --- Health & Biological Sciences --- Neuroscience --- Permeability --- Permeability. --- Blood-cerebral barrier --- Blood-cerebrospinal fluid barrier --- Brain-blood barrier --- Hemato-encephalic barrier --- Hematoencephalic barrier --- Medicine. --- Molecular biology. --- Biomedicine. --- Molecular Medicine. --- Biomedicine general. --- Molecular biochemistry --- Molecular biophysics --- Biochemistry --- Biophysics --- Biomolecules --- Systems biology --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Cerebrospinal fluid --- Choroid plexus --- Blood-vessels --- Biomedicine, general. --- Health Workforce
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Within the central nervous system (CNS) the constantly changing blood stream is separated from the CNS parenchyma by the blood brain barrier (BBB) restricting passage to selected immune cells. Under pathological conditions, however, viruses, bacteria, parasites and autoaggressive immune cells can penetrate the barrier and contribute to CNS inflammation. The BBB actively contributes to neuroinflammation by presentation of chemokines, expression of cell adhesion molecules and alteration of barrier properties. As such, understanding the role of the BBB under healthy and pathological conditions is essential for the development of new drugs to efficiently combat inflammatory diseases of the CNS. This book presents a comprehensive collection of reviews that focus on the role of the BBB. Experts in the field share their insight on structural, topological and functional properties of the BBB. They elaborate on pathophysiological changes of the inflamed BBB such as permeability, transporter proteins and alterations in microRNAs and cytokine profile. Additional chapters on multiple sclerosis and bacterial meningitis provide in depth information on significant neuroinflammatory diseases. The selection is complemented by a review on the current understanding of the BBB as signaling hub in tumor pathogenesis in the brain.
Medicine. --- Immunology. --- Neurosciences. --- Infectious diseases. --- Cytokines. --- Growth factors. --- Cell membranes. --- Biomedicine. --- Membrane Biology. --- Infectious Diseases. --- Cytokines and Growth Factors. --- Blood-brain barrier --- Blood-cerebral barrier --- Blood-cerebrospinal fluid barrier --- Brain-blood barrier --- Hemato-encephalic barrier --- Hematoencephalic barrier --- Brain --- Cerebrospinal fluid --- Choroid plexus --- Blood-vessels --- Emerging infectious diseases. --- Cellular immunity --- Immune response --- Emerging infections --- New infectious diseases --- Re-emerging infectious diseases --- Reemerging infectious diseases --- Communicable diseases --- Cell surfaces --- Cytoplasmic membranes --- Plasma membranes --- Plasmalemma --- Membranes (Biology) --- Glycocalyces --- Neural sciences --- Neurological sciences --- Neuroscience --- Medical sciences --- Nervous system --- Immunobiology --- Life sciences --- Serology --- Regulation --- Cell membranes . --- Cell growth factors --- Cellular growth factors --- Growth peptides --- Growth promoting substances --- Growth substances --- Peptide growth factors --- Peptide regulatory factors --- Polypeptide growth factors --- Cytokines --- Peptides
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