Listing 1 - 10 of 56 | << page >> |
Sort by
|
Choose an application
The blood-brain barrier serves to protect the brain from toxic substances whilst simultaneously allowing access to essential nutrients and chemical signals. At the interface between brain and body, knowledge of the blood-brain barrier forms an essential component in the complete understanding of a large proportion of medical disciplines. Nevertheless, it seems that ignorance of both the biology of this important membrane and the methodology suitable for its investigation still remains an impediment to progress in many fields, including, for example, the development of new and efficacious neuropharmaceuticals, cerebrovascular disease, Alzheimer's disease, cerebral AIDS and brain tumours. This introduction for both researchers and clinicians across the medical sciences is intended to aid both those beginning work directly in this area and those wishing simply to be better informed when interpreting information where the blood-brain barrier may be involved. Advances in both methodology and biology are detailed in 50 chapters from international authorities.
Choose an application
Choose an application
Choose an application
Nervous system --- Blood-brain barrier --- Diseases --- Treatment
Choose an application
Blood-brain barrier --- Congresses --- BLOOD-BRAIN BARRIER --- BRAIN --- BIOLOGICAL TRANSPORT --- CELL COMMUNICATION --- PHYSIOLOGY --- BLOOD SUPPLY
Choose an application
Neuropathology --- Blood-brain barrier --- Brain --- Brain edema --- Ischemia
Choose an application
This presentation describes structural and functional properties of the cerebral circulation that are unique to the brain, an organ with high metabolic demands, and the need for tight water and ion homeostasis. Autoregulation is pronounced in the brain, with myogenic, metabolic, and neurogenic mechanisms contributing to maintain relatively constant blood flow during both increases and decreases in pressure. In addition, unlike peripheral organs where the majority of vascular resistance resides in small arteries and arterioles, large extracranial and intracranial arteries contribute significantly to vascular resistance in the brain. The prominent role of large arteries in cerebrovascular resistance helps maintain blood flow and protect downstream vessels during changes in perfusion pressure. The cerebral endothelium is also unique in that its barrier properties are in some way more like epithelium than endothelium in the periphery. The cerebral endothelium, known as the blood-brain barrier, has specialized tight junctions that do not allow ions to pass freely and has very low hydraulic conductivity and transcellular transport. This special configuration modifies Starling's forces in the brain such that ions retained in the vascular lumen oppose water movement due to hydrostatic pressure. Tight water regulation is necessary in the brain because it has limited capacity for expansion within the skull. Increased intracranial pressure due to vasogenic edema can cause severe neurologic complications and death. This chapter will review these special features of the cerebral circulation and how they contribute to the physiology of the brain.
Cerebral circulation. --- Brain --- Cerebrovascular Circulation. --- Blood-vessels. --- Cerebral circulation --- Neurovascular unit --- Blood-brain barrier --- Myogenic --- Autoregulation
Choose an application
The thesis of this innovative and challenging book, first published in 2001, is that brain drug development has been restricted by the failure of adequate brain drug targeting, and that this is an increasingly urgent problem as developments in genomics lead to new generations of therapeutic macromolecules. The author, a world leader in the study of the blood-brain barrier and its clinical implications, reviews the field of neurotherapeutics from the point of view of drug targeting. He surveys the scientific and clinical basis of drug delivery across biological membranes, including topics such as genetically engineered trojan horses for drug targeting, antisense neurotherapeutics, and gene therapy of brain disorders. At a time when there are few significant new drug treatments in prospect for common neurological diseases, this authoritative review will encourage a wide range of clinicians and neuroscientists to reexamine the development and use of drugs in treating disorders of the central nervous system.
Neuropharmacology. --- Drug targeting. --- Brain --- Blood-brain barrier. --- Effect of drugs on.
Choose an application
This ebook contains a series of original publications, reviews and mini-reviews by leaders in the field that address the growing importance of the plasminogen activating system in neurobiology. The articles included cover the role of the plasminogen activating system as a key modulator of blood brain barrier permeability, and the implications of this in traumatic brain injury and in ischemic stroke. State-of-the-Art manuscripts are also included that address the regulatory mechanisms that control this important process.This ebook contains a series of original publications, reviews and mini-reviews by leaders in the field that address the growing importance of the plasminogen activating system in neurobiology. The articles included cover the role of the plasminogen activating system as a key modulator of blood brain barrier permeability, and the implications of this in traumatic brain injury and in ischemic stroke. State-of-the-Art manuscripts are also included that address the regulatory mechanisms that control this important process.
blood brain barrier --- ischaemic stroke --- plasminogen activation --- Traumatic Brain Injury --- Neurobiology --- Neuroserpin --- tissue-type plasminogen activator
Choose an application
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact
Medicine --- Oncology --- GBM --- DIPG --- diffuse intrinsic pontine glioma --- novel therapy --- blood-brain barrier --- drug delivery --- targeting
Listing 1 - 10 of 56 | << page >> |
Sort by
|