Listing 1 - 5 of 5 |
Sort by
|
Choose an application
Chemical carcinogenesis. --- Chemical induction of cancer --- Chemical induction of neoplasms --- Chemical induction of tumors --- Chemical tumorigenesis --- Chemically induced cancer --- Chemically induced neoplasm --- Chemically induced neoplasms --- Chemically induced tumor --- Chemically induced tumors --- Carcinogenesis
Choose an application
Chemical carcinogenesis --- -Chemical induction of cancer --- Chemical induction of neoplasms --- Chemical induction of tumors --- Chemical tumorigenesis --- Chemically induced cancer --- Chemically induced neoplasm --- Chemically induced neoplasms --- Chemically induced tumor --- Chemically induced tumors --- Carcinogenesis --- Congresses --- -Congresses --- Chemical induction of cancer --- Carcinogens. --- Chemical industry. --- DNA. --- DNA
Choose an application
Protein phosphorylation reactions are carried out in a cell by protein kinases, which predominantly use ATP as a phosphate donor that is transferred and covalently bound to an amino acid on a substrate protein. Protein phosphorylation was discovered in 1954 by Edmond Fischer who shared the Nobel Prize in Medicine or Physiology in 1992 with Edwin Krebs. There are so many kinases that one was called ""Just Another Kinase"" for JAK kinase. Their counterpart is protein phosphatases that remove phosphates from phosphorylated proteins. Kinases and phosphatases act as switches in the cell that activates or inactivates protein functions. These reactions are reversible; the cell can quickly react to a situation but can then go back to its initial state.
Chemical carcinogenesis. --- Chemical induction of cancer --- Chemical induction of neoplasms --- Chemical induction of tumors --- Chemical tumorigenesis --- Chemically induced cancer --- Chemically induced neoplasm --- Chemically induced neoplasms --- Chemically induced tumor --- Chemically induced tumors --- Carcinogenesis --- Life Sciences --- Genetics and Molecular Biology --- Chemical Biology --- Biochemistry --- Bioorganic Chemistry
Choose an application
This book aims to present current state of understanding of the role of metals in human health and disease. As it will be difficult to cover all of the metals, about two scores of them, the authors will instead provide a detailed analysis of a select set of essential (Calcium, Magnesium, Selenium, Iron, copper and Zinc) and non-essential metals (Nickel, Chromium, Cadmium and Arsenic, Tungsten and Asbestos). Each chapter will have a dedicated section focusing on the binary role that some of these metals play, their carcinogenic and cancer therapeutics, by integrating epidemiological, experimental evidence with special emphasis and focus on molecular mechanisms involved in these processes. The biological analysis will also include emerging lines of evidence such as micro RNAS, kinase families, receptors, endoplasmic, mitochondrial players and epigenetics. As part of integrating the human, experimental and mechanistic data, as well as a detailed analysis into the modes of action for different cancer outcomes will be discussed in each chapter wherever deemed feasible. These approaches are ones in which no other book in this area has attempted to do.
Medicine. --- Cancer research. --- Molecular biology. --- Biomedicine. --- Cancer Research. --- Molecular Medicine. --- Chemical carcinogenesis. --- Metals --- Physiological effect. --- Therapeutic use. --- Metals as antiseptics --- Chemical induction of cancer --- Chemical induction of neoplasms --- Chemical induction of tumors --- Chemical tumorigenesis --- Chemically induced cancer --- Chemically induced neoplasm --- Chemically induced neoplasms --- Chemically induced tumor --- Chemically induced tumors --- Carcinogenesis --- Oncology. --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Tumors --- Health Workforce --- Molecular biochemistry --- Molecular biophysics --- Biochemistry --- Biophysics --- Biomolecules --- Systems biology --- Cancer research
Choose an application
This monograph provides a contemporary account of advances in chemical carcinogenesis. It promotes the view that it is alteration of the DNA by endogenous and exogenous carcinogens that ultimately leads to sporadic mutations which are a root cause of many human cancers. It deals with the metabolic activation of common classes of chemical carcinogens (tobacco carcinogens, heterocyclic amines, polycyclic aromatic hydrocarbons) and their detoxication. It describes the DNA-adducts that ensue and their repair mechanisms. It covers advances in structural-biology that provide a glimpse of both the DNA-repair process and the by-pass of DNA-lesions and how this informs the mutational code. It also deals with the concepts of chemoprevention and biomarkers for biomonitoring human exposure. Many contemporary texts on the biology of cancer now focus almost exclusively on the molecular and cell biology of the disease and do not cover the initiating (DNA damaging events) of chemical carcinogenesis in depth. It is with this perceived gap-in knowledge that world experts in their particular fields have contributed to this monograph. This monograph will be an important reference re-source for students in training, postdoctoral scientists, and senior scientists knowledgeable in the field.
Chemical carcinogenesis. --- HEALTH & FITNESS / Diseases / Cancer. --- MEDICAL / Oncology. --- Chemical carcinogenesis --- Genetic Processes --- Noxae --- Drug Therapy --- Toxic Actions --- Genetic Phenomena --- Therapeutics --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Chemical Actions and Uses --- Phenomena and Processes --- Chemicals and Drugs --- Carcinogens --- DNA Damage --- Chemoprevention --- Medicine --- Health & Biological Sciences --- Oncology --- Chemical induction of cancer --- Chemical induction of neoplasms --- Chemical induction of tumors --- Chemical tumorigenesis --- Chemically induced cancer --- Chemically induced neoplasm --- Chemically induced neoplasms --- Chemically induced tumor --- Chemically induced tumors --- Medicine. --- Cancer research. --- Pharmacology. --- Biomedicine. --- Cancer Research. --- Pharmacology/Toxicology. --- Carcinogenesis --- Oncology. --- Toxicology. --- Chemicals --- Pharmacology --- Poisoning --- Poisons --- Tumors --- Toxicology --- Drug effects --- Medical pharmacology --- Medical sciences --- Chemotherapy --- Drugs --- Pharmacy --- Cancer research --- Physiological effect
Listing 1 - 5 of 5 |
Sort by
|