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Cancer --- Systems biology. --- Neoplasms --- Gene Expression Regulation, Neoplastic --- Gene Regulatory Networks --- Genes, Neoplasm --- Systems Biology --- Gene regulatory networks. --- Research --- Methodology. --- genetics. --- physiology. --- physiology. --- physiology. --- methods.

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This issue of Recent Results in Cancer Research presents a comprehensive review of current understanding of chromosomal instability in cancer and of strategies to use this information for better treatment of patients with cancer. Cancer is a disease of the chromosomes, and chromosomal instability in cancer disrupts gene function by either inactivating tumor suppressor genes or activating growth-promoting oncogenes. The chromosomal basis for these aberrations is either translocations, which change the integrity of genes, or abnormal numbers of chromosomes, a condition referred to as aneuploidy, which results in abnormal gene expression levels. Such structural or numerical chromosomal aberrations are specific for distinct tumor entities. The degree of chromosomal instability and the degree of intratumor heterogeneity have profound consequences for disease outcome and for therapeutic stratification.

Gene Expression Regulation, Neoplastic --- Chromosomal Instability --- Translocation, Genetic --- Aneuploidy --- Neoplasms --- Diseases --- Ploidies --- Genomic Instability --- Gene Expression Regulation --- Chromosome Aberrations --- Mutagenesis --- Pathologic Processes --- Mutation --- Genetic Phenomena --- Genetic Processes --- Pathological Conditions, Signs and Symptoms --- Phenomena and Processes --- Genetic Variation --- Oncology --- Medicine --- Health & Biological Sciences --- Cancer cells. --- Chromosome abnormalities. --- Chromosomal aberrations --- Chromosome anomalies --- Medicine. --- Cancer research. --- Human genetics. --- Oncology. --- Medicine & Public Health. --- Cancer Research. --- Human Genetics. --- Tumors --- Genetics --- Heredity, Human --- Human biology --- Physical anthropology --- Cancer research --- Clinical sciences --- Medical profession --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Chromosomes --- Karyotypes --- Mutation (Biology) --- Cells --- Pathology, Cellular --- Oncology  .

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This work presents the most advanced discoveries from translational research laboratories directly involved in identifying molecules and signalling pathways that play an instrumental role in metastasis. In contrast to other works, conventionally focused on a single type of tumour, the various chapters in this book provide a broad perspective of the similarities and discrepancies among the dissemination of several solid malignancies. Through recurrent and overlapping references to molecular mechanisms and mediators, the readers will gain knowledge of the common ground in metastasis from a single source. Finally, an introductory chapter provides a clinical perspective of the problems presented by metastatic tumours for diagnosis and treatment. The work presented here is directed to researchers in tumour biology with a developing interest in metastatic dissemination as well as medical and graduate students seeking to expand and integrate the notions acquired in basic cancer biology and oncology courses.

Lymphatic Metastasis. --- Metastasis. --- Neoplasm Metastasis. --- Signal Transduction. --- Metastasis --- Pathologic Processes --- Biochemical Processes --- Cell Physiological Processes --- Neoplasms --- Biological Science Disciplines --- Gene Expression Regulation --- Genetic Processes --- Biochemical Phenomena --- Cell Physiological Phenomena --- Natural Science Disciplines --- Pathological Conditions, Signs and Symptoms --- Chemical Processes --- Diseases --- Chemical Phenomena --- Disciplines and Occupations --- Genetic Phenomena --- Phenomena and Processes --- Gene Expression Regulation, Neoplastic --- Neoplastic Processes --- Neoplasm Metastasis --- Signal Transduction --- Physiology --- Medicine --- Health & Biological Sciences --- Oncology --- Cancer invasiveness. --- Cancer --- Molecular aspects. --- Dissemination of cancer --- Invasiveness (Oncology) --- Neoplasm invasiveness --- Spread of cancer --- Tumor dissemination --- Tumor invasiveness --- Tumor progression --- Tumor spread --- Cancer metastasis --- Metastases --- Metastatic cancer --- Neoplasm metastasis --- Tumor metastasis --- Dissemination --- Medicine. --- Cancer research. --- Medical genetics. --- Oncology. --- Proteins. --- Cytokines. --- Growth factors. --- Biomedicine. --- Cancer Research. --- Gene Function. --- Receptors. --- Cytokines and Growth Factors. --- Cancer cells --- Pathology --- Cancer invasiveness --- Cancer of unknown primary origin --- Growth --- Oncology  . --- Cell receptors. --- Cellular immunity --- Immune response --- Cell membrane receptors --- Cell surface receptors --- Receptors, Cell --- Binding sites (Biochemistry) --- Cell membranes --- Proteins --- Clinical genetics --- Heredity of disease --- Human genetics --- Medical sciences --- Genetic disorders --- Tumors --- Regulation --- Genetic aspects --- Proteins . --- Cell growth factors --- Cellular growth factors --- Growth peptides --- Growth promoting substances --- Growth substances --- Peptide growth factors --- Peptide regulatory factors --- Polypeptide growth factors --- Cytokines --- Peptides --- Proteids --- Biomolecules --- Polypeptides --- Proteomics --- Cancer research

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Carcinogenesis --- Cancer --- Disease Susceptibility --- Cells --- Age Factors --- Diseases --- Genotype --- Gene Expression Regulation --- Genetic Processes --- Epidemiologic Factors --- Anatomy --- Genetic Phenomena --- Disease Attributes --- Pathologic Processes --- Phenomena and Processes --- Quality of Health Care --- Public Health --- Environment and Public Health --- Pathological Conditions, Signs and Symptoms --- Health Care Quality, Access, and Evaluation --- Health Care --- Age of Onset --- Gene Expression Regulation, Neoplastic --- Neoplasms --- Stem Cells --- Genetic Predisposition to Disease --- Mutagenesis --- Medicine --- Health & Biological Sciences --- Oncology --- Age factors --- Genetic aspects --- Epidemiology --- Predisposition, Genetic --- Susceptibility, Genetic --- Genetic Predisposition --- Genetic Susceptibility --- Genetic Predispositions --- Genetic Susceptibilities --- Predispositions, Genetic --- Susceptibilities, Genetic --- Colony-Forming Unit --- Colony-Forming Units --- Mother Cells --- Progenitor Cells --- Cell, Mother --- Cell, Progenitor --- Cell, Stem --- Cells, Mother --- Cells, Progenitor --- Cells, Stem --- Colony Forming Unit --- Colony Forming Units --- Mother Cell --- Progenitor Cell --- Stem Cell --- Benign Neoplasms --- Malignancy --- Neoplasia --- Neoplasm --- Neoplasms, Benign --- Tumors --- Benign Neoplasm --- Cancers --- Malignancies --- Neoplasias --- Neoplasm, Benign --- Tumor --- Mutageneses --- Regulation, Gene Expression, Neoplastic --- Neoplastic Gene Expression Regulation --- Regulation of Gene Expression, Neoplastic --- Age-at-Onset --- Age at Onset --- Onset Age --- Healthcare Quality, Access, and Evaluation --- Symptoms and General Pathology --- Community-Based Distribution --- Contraceptive Distribution --- Delivery of Healthcare --- Dental Care Delivery --- Distribution, Non-Clinical --- Distribution, Nonclinical --- Distributional Activities --- Healthcare --- Healthcare Delivery --- Healthcare Systems --- Non-Clinical Distribution --- Nonclinical Distribution --- Delivery of Dental Care --- Health Care Delivery --- Health Care Systems --- Activities, Distributional --- Activity, Distributional --- Care, Health --- Community Based Distribution --- Community-Based Distributions --- Contraceptive Distributions --- Deliveries, Healthcare --- Delivery, Dental Care --- Delivery, Health Care --- Delivery, Healthcare --- Distribution, Community-Based --- Distribution, Contraceptive --- Distribution, Non Clinical --- Distributional Activity --- Distributions, Community-Based --- Distributions, Contraceptive --- Distributions, Non-Clinical --- Distributions, Nonclinical --- Health Care System --- Healthcare Deliveries --- Healthcare System --- Non Clinical Distribution --- Non-Clinical Distributions --- Nonclinical Distributions --- System, Health Care --- System, Healthcare --- Systems, Health Care --- Systems, Healthcare --- Environment, Preventive Medicine & Public Health --- Environment, Preventive Medicine and Public Health --- Health, Public --- Quality of Care --- Quality of Healthcare --- Care Qualities --- Care Quality --- Health Care Quality --- Healthcare Quality --- Pathological Processes --- Processes, Pathologic --- Processes, Pathological --- Attribute, Disease --- Attributes, Disease --- Disease Attribute --- Genetic Concepts --- Genetic Phenomenon --- Genetic Process --- Concept, Genetic --- Concepts, Genetic --- Genetic Concept --- Phenomena, Genetic --- Phenomenon, Genetic --- Process, Genetic --- Processes, Genetic --- Anatomies --- Determinant, Epidemiologic --- Determinants, Epidemiologic --- Epidemiologic Determinant --- Epidemiologic Factor --- Factor, Epidemiologic --- Factors, Epidemiologic --- Epidemiologic Determinants --- Expression Regulation, Gene --- Regulation, Gene Action --- Regulation, Gene Expression --- Gene Action Regulation --- Regulation of Gene Expression --- Genogroup --- Genogroups --- Genotypes --- Age Reporting --- Age Factor --- Factor, Age --- Factors, Age --- Cell --- Susceptibility, Disease --- Diathesis --- Diatheses --- Disease Susceptibilities --- Susceptibilities, Disease --- Carcinoma --- Malignancy (Cancer) --- Malignant tumors --- Cancer genetics --- Oncogenesis --- Pathogenesis of cancer --- Tumorigenesis --- genetics --- Pathogenesis --- Genetic Testing --- Anticipation, Genetic --- Genetic Association Studies --- Gene-Environment Interaction --- Cell Self Renewal --- Stem Cell Research --- Malignant Neoplasms --- Malignant Neoplasm --- Neoplasm, Malignant --- Neoplasms, Malignant --- Medical Oncology --- Mutation Accumulation --- Mutagens --- Mutation --- Teratogenesis --- Community Health --- Health, Community --- Preventive Medicine --- Education, Public Health Professional --- Pharmacy Audit --- Audit, Pharmacy --- Pharmacy Audits --- Molecular Biology --- RNAi Therapeutics --- Gene Regulatory Networks --- Genotyping Techniques --- Cell Biology --- Cancer genes --- Pathology --- Genetic toxicology --- Age of Onset. --- Gene Expression Regulation, Neoplastic. --- Genetic Predisposition to Disease. --- Mutagenesis. --- Stem Cells. --- etiology.