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Platelets have become an important research target for clinicians and basic scientists in a range of medical disciplines. This book reviews current science and applications in fields including thrombosis and hemostasis, signal transduction, and non-thrombotic conditions such as inflammation, allergy and tumor metastasis. It is a detailed, up-to-date, highly referenced text for clinical scientists and physicians, including recent developments in this rapidly expanding field. More than a scientific resource, this is also an authoritative reference and guide to the diagnosis and therapeutics of diseases involving platelets. Chapters are devised to provide a critical review of the most clinically relevant aspects of the subject. It will be an essential reference for biomedical scientists and clinicians in hematology, vascular medicine, cardiology, thrombosis and related disciplines.
Blood platelet disorders. --- Blood platelets --- Blood platelet receptors --- Platelet membrane receptors --- Platelet receptors --- Cell receptors --- Thrombocytopathy --- Blood --- Adhesiveness, Blood platelet --- Aggregation, Blood platelet --- Blood platelet aggregation --- Platelet adhesiveness --- Platelet aggregation --- Cell aggregation --- Receptors. --- Aggregation. --- Diseases --- Blood platelet disorders --- Blood Platelet Disorders --- Blood Platelets --- Platelet Aggregation Inhibitors --- Aggregation --- Receptors --- physiopathology --- drug effects --- pathology --- physiology --- therapeutic use
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Aspirin has been in clinical use for over 100 years, making it one of the oldest commonly used drugs in medicine, and is now predominantly used as an antiplatelet agent. Major new antiplatelet drug classes have recently become available for the clinician that offer the promise of major improvements in the treatment and prevention of arterial thrombotic disease. In the field of anticoagulation, the vitamin K antagonists such as warfarin have not been available for as long as aspirin in the antiplatelet field, and have also had very little in the way of competition until recently; although a number of parenteral anticoagulants have been available, the vitamin K antagonists have been the only orally active anticoagulant drugs. The last few years have seen the arrival of new drug classes, the orally active direct thrombin inhibitors and factor Xa antagonists, which offer a number of advantages, but not without important drawbacks. In the face of these important advances in both antiplatelet and anticoagulant therapy, clinicians often feel confused, even overwhelmed, as to what is now available and which drugs are useful (and indicated) in which circumstances. Antiplatelet and Anticoagulant Therapy is designed with such people in mind. It is written in an easy-to-follow format and with many illustrations to aid clarity and the assimilation of information. Each chapter is written by established authorities in their fields who are also experienced in explaining often complex concepts. The result is a unique book which is not only comprehensive but also clear and useful for the busy medical practitioner.
Anticoagulants (Medicine). --- Anticoagulants (Medicine) --- Blood --- Blood platelets --- Blood coagulation disorders --- Biological Factors --- Hematologic Agents --- Vascular Diseases --- Embolism and Thrombosis --- Cardiovascular Diseases --- Therapeutic Uses --- Chemicals and Drugs --- Diseases --- Pharmacologic Actions --- Chemical Actions and Uses --- Thrombosis --- Platelet Aggregation Inhibitors --- Blood Coagulation Factor Inhibitors --- Arterial Occlusive Diseases --- Medicine --- Health & Biological Sciences --- Hematologic Diseases --- Pharmacy, Therapeutics, & Pharmacology --- Coagulation --- Chemotherapy --- Blood platelets. --- Antithrombotic agents --- Blood thinners --- Blood thinning drugs --- Platelets --- Thrombocytes --- Medicine. --- Cardiology. --- Medicine & Public Health. --- Medicine/Public Health, general. --- Hematologic agents --- Blood cells --- Megakaryocytes --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Heart --- Internal medicine --- Health Workforce
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