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PHOSPHOLIPASE C --- STRUCTURE-ACTIVITY RELATIONSHIP --- PHOSPHOLIPASE C --- STRUCTURE-ACTIVITY RELATIONSHIP
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STRUCTURE-ACTIVITY RELATIONSHIP --- ENZYMES --- STRUCTURE-ACTIVITY RELATIONSHIP --- ENZYMES
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Protein hormones --- Structure-activity relationship (Biochemistry) --- Peptide hormones --- Polypeptides
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For thousands of years, pharmacological knowledge coming from natural remedies, has been handed down from generation to generation, without any awareness of the ways in which preparations are made to face diseases. The advent of pharmaceutical chemistry and of the modern drug industry turned that lack of awareness into a scientific knowledge that changed the destiny of the human race. The twenty-eight chapters of this book, are taken from the lectures held by Professor Ettore Novellino every year in his course “Pharmaceutical Chemistry and Toxicology 2”. The first chapters address the basic notions of drugs, homeostasis, pharmacopoeia, and receptor; then, the different pharmaceutical classes are introduced by analyzing their pharmacological and chemical aspects. In particular, the structural study of the interaction between drugs and receptors or biological enzymes gives the fundamentals to connect the chemical and stereochemical properties of a compound family, with the biological activity, a correlation better known as Quantitative Structure-Activity Relationship (QSAR). Several examples of the synthesis of some of the most historically renown drugs, provided at the end of each chapter, integrate the book.
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Membrane proteins --- Membrane Proteins --- Structure-Activity Relationship --- Congresses.
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Hormone Antagonists --- Receptors, Steroid --- Structure-Activity Relationship --- Antagonists --- Steroid hormones --- Congresses. --- congresses. --- Congresses --- Steroid hormones - Antagonists - Congresses. --- Hormone Antagonists - congresses --- Receptors, Steroid - congresses. --- Structure-Activity Relationship - congresses. --- Hormone antagonists --- Molecular structure-biological activity relationship --- Receptors, steroid
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QSAR in Safety Evaluation and Risk Assessment provides comprehensive coverage on QSAR methods, tools, data sources, and models focusing on applications in products safety evaluation and chemicals risk assessment. Organized into five parts, the book covers almost all aspects of QSAR modeling and application. Topics in the book include methods of QSAR, from both scientific and regulatory viewpoints; data sources available for facilitating QSAR models development; software tools for QSAR development; and QSAR models developed for assisting safety evaluation and risk assessment. Chapter contributors are authored by a lineup of active scientists in this field. The chapters not only provide professional level technical summarizations but also cover introductory descriptions for all aspects of QSAR for safety evaluation and risk assessment.
Drugs --- QSAR (Biochemistry) --- Quantitative structure-activity relationships (Biochemistry) --- Structure-activity relationships (Biochemistry) --- Structure-activity relationship (Pharmacology) --- Pharmaceutical chemistry --- Pharmacology --- Structure-activity relationships. --- Quantitative Structure-Activity Relationship --- Consumer Product Safety --- Environmental Pollutants --- Toxicity Tests
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Antibiotics --- Structure-Activity Relationship --- Drugs --- Antibiotiques --- Médicaments --- Structure-activity relationships --- Relations structure-activité --- Anti-Bacterial Agents. --- Médicaments --- Relations structure-activité --- Structure-Activity Relationship. --- Structure-activity relationship (Pharmacology) --- Pharmaceutical chemistry --- Pharmacology --- Structure-activity relationships (Biochemistry) --- Anti-infective agents --- Microbial metabolites --- Allelopathic agents --- Antibiosis --- Pharmaceutical microbiology --- Phytoncides --- Drugs - Structure-activity relationships --- Molecular structure-biological activity relationship
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