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Ethics, Medical --- Genetic Predisposition to Disease --- Biomedical Research --- ethics --- Biomedical Research - ethics
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Medicine, Experimental --- Biomedical Research --- Human Experimentation --- Animal Experimentation
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Medicine, Experimental --- Biomedical Research --- Human Experimentation --- Animal Experimentation
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Medicine, Experimental --- Biomedical Research --- Human Experimentation --- Animal Experimentation
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Quatrième de couverture : "L'originalité de l'ouvrage réside dans "L'approche généraliste" qui, sans entrer de manière détaillée sur tel ou tel aspect du sujet, tente de globaliser les connaissances en plaçant la cellule cancéreuse sous le projecteur des diverses disciplines biologiques. Après un rappel des dérèglements génétiques fondamentaux, accompagnant la cancérisation, les rapports entre la cellule maligne et l'organisme sont considérés. L'auteur compare le comportement de la cellule cancéreuse avec celui des cellules saines sollicitées dans l'embryogenèse, la cicatrisation, la régénération, le développement du système immunitaire... Il étudie ensuite le métabolisme altéré des cellules cancéreuses. Enfin, les liens entre inflammation, immunité et cancer sont discutés. Les méthodes préventives et curatives sont ensuite présentées et le problème de la signification biologique du cancer est posé. L'ouvrage présente des qualités novatrices sur le plan des concepts ou des idées. L'approche originale du sujet conduit à envisager des prolongements en biologie fondamentale et en biologie appliquée. Cet ouvrage fait la synthèse des approches médicales et biologiques du sujet."
Tumeurs. --- Recherche biomédicale. --- Cellules cancéreuses. --- Médecine --- Recherche. --- Neoplasms --- Cancer cells --- Research --- Cellules cancéreuses --- Recherche --- pathology --- Biomedical research --- Tumeurs --- Recherche biomédicale. --- Cellules cancéreuses. --- Médecine --- Cellules cancéreuses --- Neoplasms. --- pathology. --- Biomedical Research. --- Biomedical Research
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Animals, Laboratory --- Animal experimentation --- Biomedical Research --- Models, Animal --- Animaux de laboratoire --- Expérimentation animale --- Animal Experimentation. --- Animal Experimentation --- Animals, Laboratory. --- Biomedical Research. --- Models, Animal.
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Given the vital importance of immune system research, the gathering of clear, consistent, and informative protocols involving the study of dendritic cells is paramount. Bringing the popular first edition fully up to date, Dendritic Cell Protocols, Second Edition presents protocols from experts in the field that cover the basics and more complex forays into the exploration of DC development and function, both in mice and humans. The first section of the volume involving humans explores topics such as the isolation of blood DC subtypes, primary skin Langerhans cells, and the generation of gene-manipulated human DCs with the inclusion of more clinically relevant methods as well, while the second section involving rodent models delves into DC and precursor generation in vitro, isolation ex vivo, disease models, as well as DC functions and properties. Written in the highly successful Methods in Molecular Biology™ series style, chapters include introductions to their respective subjects, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls. Comprehensive and cutting-edge, Dendritic Cell Protocols, Second Edition aims to become a bench-side handbook for both beginners and experts in the field of DC research and a long-term reference for some of the most popular methods put forward by those who lead the field.
Immunology. --- Cytology. --- Medical laboratories. --- Cell Biology. --- Laboratory Medicine. --- Immunobiology --- Life sciences --- Serology --- Diagnosis, Laboratory --- Health facilities --- Laboratories --- Cell biology --- Cellular biology --- Biology --- Cells --- Cytologists --- Dendritic cells - Laboratory manuals --- Medicine --- Biomedical Research. --- Health Workforce --- Biological research --- Biomedical research --- Research. --- Dendritic cells
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During the past decade, remarkable progress has been made in the development of newer drugs to prevent and treat thromboembolic disorders, such as oral direct anti-Xa and anti-IIa antagonists, as well as oral antiplatelet ADP antagonists with rapid onset and offset. In addition, there has been concentrated effort aimed at identifying novel uses of traditional antithrombotic drugs, such as aspirin, heparin, and oral anticoagulants, as well as combinations of agents, such as more than one antiplatelet, antiplatelet with anticoagulant, antiplatelet with or without thrombolytic. Anticoagulants, Antiplatelets, and Thrombolytics, Second Edition provides updates on various strategies in thrombosis, experimental models, and clinical and recent advances in the discovery and development of novel antithrombotics. As a volume in the highly successful Methods in Molecular Biology™ series, this collection provides the kind of detailed description and implementation advice that is crucial for getting optimal results. Easy to use and up to date, Anticoagulants, Antiplatelets, and Thrombolytics, Second Edition is an ideal guide for researchers aiming for the future of this vital field, focusing on the prevention of thromboembolic disorders and the protection of the vascular endothelium.
Medicine. --- Cardiology. --- Molecular Medicine. --- Heart --- Internal medicine --- Health Workforce --- Diseases --- Anticoagulants (Medicine) --- Blood platelets --- Thrombolytic therapy --- Fibrinolytic agents --- Thrombolytic therapy - Methods --- Fibrinolytic agents - Therapeutic use --- Heparin - Therapeutic use --- Medicine --- Biology --- Biomedical Research. --- Biological research --- Biomedical research --- Research. --- Heparin
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Le livre introduit la biologie contemporaine par l’histoire de ses origines. Au travers des interrogations et des errements des pionniers de cette discipline, le lecteur appréhende la complexité des processus inhérents à la vie et acquiert une vision d’ensemble sur l’état actuel de nos connaissances. Ainsi l’auteur retrace-t-il les théories de l’évolution, les démarches qui ont conduit à la biologie cellulaire, à la biologie moléculaire et au déchiffrage du métabolisme cellulaire, en insistant sur les liens qui les unissent. L’ouvrage comprend de nombreuses illustrations, un index des auteurs et un glossaire pour faciliter la lecture de celui qui ne dispose pas de bases classiques de biologie.
Biologie --- Histoire --- Geschiedenis der geneeskunde --- Histoire de la médecine --- Biology --- History --- Biology- history --- Biomedical Research -history --- Bioethical Issues --- Biologie - Histoire
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Learn rigorous statistical methods to ensure valid clinical trialsThis Second Edition of the critically hailed Clinical Trials builds on the text's reputation as a straightforward and authoritative presentation of statistical methods for clinical trials. Readers are introduced to the fundamentals of design for various types of clinical trials and then skillfully guided through the complete process of planning the experiment, assembling a study cohort, assessing data, and reporting results. Throughout the process, the author alerts readers to problems that may arise during the course of
Pharmacology. Therapy --- Biomedical Research --- Clinical Trials --- Clinical trials --- Research --- Statistics --- methods. --- Statistical methods. --- Research Design --- Clinical Trials as Topic --- Statistics as Topic --- Statistical methods --- methods
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