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This Handbook brings together and integrates comprehensively the core approaches to fear and anxiety. Its four sections: Animal models; neural systems; pharmacology; and clinical approaches, provide a range of perspectives that interact to produce new light on these important and sometimes dysfunctional emotions. Fear and anxiety are analyzed as patterns that have evolved on the basis of their adaptive functioning in response to threat. These patterns are stringently selected, providing a close fit with environmental situations and events; they are highly conservative across mammalian speci

Animal models in research. --- Anxiety disorders --- Anxiety --- Fear --- Chemotherapy. --- Physiological aspects --- Research. --- Physiological aspects. --- Fright --- Emotions --- Horror --- Angst --- Anxieties --- Anxiousness --- Stress (Psychology) --- Agitation (Psychology) --- Worry --- Anxiety neuroses --- Anxiety states, Neurotic --- Neurotic anxiety states --- Neuroses --- Animal experimentation --- Biological models --- Laboratory animals --- Research

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Cellular and Animal Models in Human Genomics Research provides an indispensable resource for applying comparative genomics in the annotation of disease-gene associated variants that are identified by human genomic sequencing. The book presents a thorough overview of effective protocols for the use of cellular and animal modeling methods to turn lists of plausible genes into causative biomarkers. With chapters written by international experts, the book first addresses the fundamental aspects of using cellular and animal models in genetic and genomic studies, including in-depth examples of specific models and their utility, i.e., yeast, worms, flies, fish, mice and large animals. Protocols for properly conducting model studies, genomic technology, modeling candidate genes vs. genetic variants, integrative modeling, utilizing induced pluripotent stem cells, and employing CRISPR-Cas9 are also discussed in-depth. Provides a thorough, accessible resource that helps researchers and students employ cellular and animal models in their own genetic and genomic studies Offers guidance on how to effectively interpret the results and significance of genetic and genomic model studies for human health Features chapters from international experts in the use of specific cellular and animal models, including yeast, worms, flies, fish, mice, and large animals, among other organisms.

Human gene mapping. --- Animal models in research. --- Biological models. --- Genomics. --- Cytological Techniques. --- Models, Biological. --- Disease Models, Animal. --- Animal Disease Model --- Animal Disease Models --- Disease Model, Animal --- Animals, Laboratory --- Models, Biological --- Biological Model --- Biological Models --- Model, Biological --- Models, Biologic --- Biologic Model --- Biologic Models --- Model, Biologic --- Cytologic Technics --- Cytological Technic --- Cytological Technics --- Cytological Technique --- Technic, Cytological --- Technics, Cytological --- Technique, Cytological --- Techniques, Cytological --- Cytologic Technic --- Technic, Cytologic --- Technics, Cytologic --- Cell Biology --- Comparative Genomics --- Comparative Genomic --- Genomic, Comparative --- Genomics, Comparative --- Human Genome Project --- Genome --- Animal experimentation --- Biological models --- Laboratory animals --- Research --- Human chromosome mapping --- Human genome mapping --- Mapping, Human gene --- Gene mapping --- methods --- Diseases --- Animal models. --- Genome research --- Genomes --- Molecular genetics --- Animal disease models --- Disease models, Animal --- Animal models in research --- Medicine, Comparative --- Medicine, Experimental --- Pathology, Comparative --- Pathology, Experimental

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Advances in the Study of Behavior was initiated over 40 years ago to serve the increasing number of scientists engaged in the study of animal behavior. That number is still expanding. This volume makes another important ""contribution to the development of the field"" by presenting theoretical ideas and research to those studying animal behavior and to their colleagues in neighboring fields. Advances in the Study of Behavior is now available online at ScienceDirect full-text online from volume 30 onward.

Human behavior. --- Psychology, Comparative. --- Animal models in research. --- Birds --- Behaviorism (Psychology) --- Behavioralism (Psychology) --- Behavioristic psychology --- Behaviouralism (Psychology) --- Behaviourism (Psychology) --- Scientific behaviorism --- Psychology --- Animal experimentation --- Biological models --- Laboratory animals --- Research --- Behavior, Comparative --- Comparative behavior --- Comparative psychology --- Ethology, Comparative --- Intelligence of animals --- Zoology --- Animal behavior --- Animal intelligence --- Animal psychology --- Human behavior --- Instinct --- Action, Human --- Behavior, Human --- Ethology --- Human action --- Human beings --- Human biology --- Physical anthropology --- Social sciences --- Psychology, Comparative --- Behavior. --- Behavior