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Periodical
Pharmacochemistry library.
ISSN: 22120637 Year: 1977 Publisher: Amsterdam, New York, Elsevier Scientific Pub. Co.,

XIVth International Symposium on Medicinal Chemistry
Author:
ISBN: 0444827986 9786611795863 1281795860 008054388X 9780444827982 9780080543888 Year: 1997 Publisher: Amsterdam New York Elsevier

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Abstract

Vaso-occlusive disorders including unstable angina, myocardial infarction, transient ischemic attacks, stroke and peripheral artery disease remain the major sources of morbidity and mortality in western civilization. Platelet activation and resulting platelet aggregation play a major role in the pathogenesis of these thromboembolic diseases. Recognition of the contribution of platelets to the pathophysiology of cardiovascular disease has provided impetus for the continued search for new antiplatelet agents.


Book
Medicinal chemistry of chemotherapeutic agents
Authors: ---
ISBN: 0323907016 0323905757 9780323907019 9780323905756 Year: 2022 Publisher: London Academic Press

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Abstract

Medicinal Chemistry of Chemotherapeutic Agents: A Comprehensive Resource of Anti-infective and Anti-cancer Drugs focuses on the basics and fundamentals of chemistry involved in chemotherapeutic agents. Each chapter comprises distinct chemical classifications that include structure and IUPAC nomenclature, synthetic schemes and routes for each drug, mechanism of the drug action, metabolic pathway and structure-activity relationship (SAR) studies. The book covers current research focused on drug resistance and methods to overcome it, the development of newer drugs belonging to each category of the chemotherapeutic agents, molecules currently under clinical trials, and newly approved drugs, if any. This book will be a valuable resource for academics and researchers, helping them to understand the fundamentals of the medicinal chemistry of the chemotherapeutic agents. Includes current research focused on drug resistance and methods to overcome problems Outlines synthetic schemes and metabolic pathways of chemotherapeutic agents Discusses molecules under clinical trials and newly approved drugs.


Periodical
European journal of medicinal chemistry
Author:
ISSN: 17683254 02235234 Year: 1974 Publisher: [Amsterdam] : Elsevier Science

Medicinal chemistry of anticancer drugs
Authors: ---
ISBN: 9780444528247 0444528245 9780080570327 0080570321 9780080559629 008055962X 9786611279608 6611279601 9780444626677 0444626670 Year: 2008 Publisher: Amsterdam Boston Elsevier

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Abstract

Antitumor chemotherapy is nowadays a very active field of research, and a huge amount of information on the topic is generated every year. Although many books are available that deal with clinical aspects of cancer chemotherapy, this book addresses the need for an updated treatment from the point of view of medicinal chemistry and drug design. The focus of Medicinal Chemistry of Anticancer Drugs is on the mechanism of action of antitumor drugs from the molecular point of view and on the relationship between chemical structure and chemical and biochemical reactivity of antitumor agents,

The practice of medicinal chemistry
Author:
ISBN: 0127444815 9786611012250 1281012254 0080497772 9780127444819 9780080497778 Year: 2003 Publisher: Amsterdam Boston Academic Press

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Abstract

Most medicinal chemists working in the pharmaceutical industry are organic synthetic chemists with little or no background in medicinal chemistry. These chemists must acquire a good knowledge of medicinal chemistry during their first years in the pharmaceutical/drug discovery industry. This book aims to be their practical handbook - a complete guide to the drug discovery process. The book reviews practical aspects of Medicinal Chemistry, emphasising the daily problems met by the medicinal chemist when dealing with lead discovery/identification methodologies, with structure-activity


Book
The practice of medicinal chemistry
Author:
ISBN: 9780123741943 0123741947 9786611795443 1281795445 0080568777 9780080568775 9780080919058 0080919057 9780123948199 0123948193 9780123694416 0123694418 9780123948038 0123948037 1282285416 1680150898 Year: 2008

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Abstract

Now in its third edition, this classic reference is the one-stop-shop for information on the foundations of medicinal chemistry for pharmaceutical researchers who are involved in drug development & discovery but who do not have a background in medicinal chemistry. Wermuth aids pharmaceutical researchers and chemists in making faster, more accurate identifications of the active substances that could potentially treat the disorder they are researching. New chapters on Drug Absorption & Transport give pharmaceutical scientists information on how potential drugs can move through the drug discovery

Keywords

Pharmaceutical chemistry --- Drugs --- Chimie pharmaceutique --- Médicaments --- Design --- Conception --- Pharmaceutical chemistry. --- Chimie pharmaceutique (Trad. du MeSH) --- Modèles chimiques (Trad. du MeSH) --- Chimie pharmaceutique. --- Pharmaceutical Preparations --- Design. --- Conception. --- chemistry. (MeSH - aucune traduction) --- Chemical models. --- Drugs. --- Pharmaceutical Preparations. --- Chemistry, Pharmaceutical --- Models, Chemical --- Chemistry --- Models, Theoretical --- Pharmacology --- Chemicals and Drugs --- Investigative Techniques --- Biological Science Disciplines --- Natural Science Disciplines --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Disciplines and Occupations --- Pharmacy, Therapeutics, & Pharmacology --- Health & Biological Sciences --- Médicaments --- Drug design --- Pharmaceutical design --- Drug development --- Chemistry, Medical and pharmaceutical --- Drug chemistry --- Medical chemistry --- Medicinal chemistry --- Pharmacochemistry --- Cellular signal transduction. --- Mechanotransduction, Cellular --- Cellular Mechanotransduction --- Mechanosensory Transduction --- Signal Transduction, Mechanical --- Mechanical Signal Transduction --- Transduction, Mechanosensory --- Podosomes --- Mechanoreceptors --- Cellular information transduction --- Information transduction, Cellular --- Signal transduction, Cellular --- Bioenergetics --- Cellular control mechanisms --- Information theory in biology --- Signal Transduction. --- Transduction du signal cellulaire --- Cellular signal transduction --- ELSEVIER-B EPUB-LIV-FT --- Cellular control mechanisms. --- Cell regulation --- Biological control systems --- Cell metabolism --- chemistry --- Modèles chimiques (Trad. du MeSH) --- chemistry.

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