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Begins with an historical overview of the early discoveries surrounding DNA methylation in the mammalian brain and then explores the evidence supporting a role for this epigenetic mechanism in controlling gene expression programs across the lifespan in both normal and diseased states. Chapters describe new directions and technological advances, and provide an overview of what the future holds for this exciting new field. This book is ideal for medical, graduate and advanced undergraduate students, but is also a great resource for researchers who need a broad introduction to the dynamic nature of DNA that sheds light on evolving concepts of gene-environment interaction and their effects on adaptation and neuropsychiatric disease.--

Gene expression.

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Epigenetic Gene Expression and Regulation reviews current knowledge on the heritable molecular mechanisms that regulate gene expression, contribute to disease susceptibility, and point to potential treatment in future therapies. The book shows how these heritable mechanisms allow individual cells to establish stable and unique patterns of gene expression that can be passed through cell divisions without DNA mutations, thereby establishing how different heritable patterns of gene regulation control cell differentiation and organogenesis, resulting in a distinct human organism with a variety of differing cellular functions and tissues. The work begins with basic biology, encompasses methods, cellular and tissue organization, topical issues in epigenetic evolution and environmental epigenesis, and lastly clinical disease discovery and treatment. Each highly illustrated chapter is organized to briefly summarize current research, provide appropriate pedagogical guidance, pertinent methods, relevant model organisms, and clinical examples. - Reviews current knowledge on the heritable molecular mechanisms that regulate gene expression, contribute to disease susceptibility, and point to potential treatment in future therapies - Helps readers understand how epigenetic marks are targeted, and to what extent transgenerational epigenetic changes are instilled and possibly passed onto offspring - Chapters are replete with clinical examples to empower the basic biology with translational significance - Offers more than 100 illustrations to distill key concepts and decipher complex science.

Epigenetics. --- Gene expression. --- Genetic regulation.

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The Regulatory Genome in Adaptation, Evolution, Development, and Disease synthesizes insights from recent genomic and gene expression studies across organisms, from humans to plants, animals, and single cell life, exploring common roles gene regulation plays in adaptive evolution, developmental biology and susceptibility to disease. The book sheds light on gene regulation across evolutionary timelines, illuminating new areas of focus and future research. Chapters consider key elements in gene expression regulation, fundamentals of genomic alterations over time, and in response to environmental and local conditions, epigenetics in adaptive evolution, and adaptive gene regulation in healthy processes and developmental biology, and in disease biology. Throughout the book, a comparative approach is adopted across organisms to highlight common evolutionary themes and genome diversity revealed by recent sequencing and GWAS studies, as well as how this informs our understanding of human adaptive evolution. The book finishes by detailing how we can use this knowledge to impact disease outcomes and healthy human metabolism, development, and physiology. Reviews key elements in the regulation of gene expression and modes of studying gene regulation across evolutionary timelines Adopts a cross-species view, synthesizing recent sequencing and GWAS studies across organisms to draw out fresh meaning and highlight pathways for future research Considers altered gene expression associated with developmental defects and disease, as well as healthy biology and physiology, and our adaptive response to disease influence.

Genetic regulation. --- Gene expression --- Gene expression regulation --- Gene regulation --- Biosynthesis --- Cellular control mechanisms --- Molecular genetics --- Regulation --- Gene expression. --- Medical genetics. --- Gene Expression Regulation

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Gene Expression Systems: Using Nature for the Art of Expression offers detailed information on a wide variety of gene expression systems from an array of organisms. It describes several different types of expression systems including transient, stable, viral, and transgenic systems. Each chapter is written by a leader in the field. The book includes timelines and examples for each expression system, and provides an overview of the future of recombinant protein expression.Key Features* Provides detailed information on expression systems* Covers a variety of promoters and

Gene expression. --- Prokaryotes --- Insects --- Transgenic animals --- Eukaryotic cells. --- Genetics.

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The interaction between biology and evolution has been the subject of great interest in recent years. Because evolution is such a highly debated topic, a biologically oriented discussion will appeal not only to scientists and biologists but also to the interested lay person. This topic will always be a subject of controversy and therefore any breaking information regarding it is of great interest.The author is a recognized expert in the field of developmental biology and has been instrumental in elucidating the relationship between biology and evolution. The study of evolution is of intere

Cell differentiation. --- Developmental genetics. --- Developmental genetics. Genetic regulation. --- Gene expression. --- Gene Expression Regulation. --- Genetic regulation. --- Genome. --- Genomes. --- Gene Expression Regulation --- Genome --- Biological Evolution --- Transcription, Genetic --- Cell Differentiation --- Genetic Processes --- Genetic Structures --- Biochemical Processes --- Cell Physiological Processes --- Biological Processes --- Gene Expression --- Cell Physiological Phenomena --- Chemical Processes --- Biochemical Phenomena --- Genetic Phenomena --- Biological Phenomena --- Chemical Phenomena --- Phenomena and Processes --- Genetics --- Biology --- Health & Biological Sciences --- Gene expression --- Gene expression regulation --- Gene regulation --- Regulation --- Biosynthesis --- Cellular control mechanisms --- Molecular genetics --- Developmental biology --- Embryology --- Growth