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'Vertebrate Hair Cells' provides a current overview of the mechanosensory receptor cells of the vertebrate inner ear. Each chapter is written by experimentalists active in exploring a particular aspect of hair cell function, including development, mechanoelectrical transduction, and synaptic transmission. Hair cell research has entered an exciting phase in which the convergence of molecular/genetic and biophysical methods is stimulating a rapid expansion in our understanding of function. The intended audience ranges from senior undergraduates to scientists in the field of hair cell research. Ruth Anne Eatock is Professor in the Department of Otolaryngology at Baylor College of Medicine, Houston, Texas. Richard R. Fay is Director of the Parmly Hearing Institute and Professor of Psychology at Loyola University of Chicago. Arthur N. Popper is Professor in the Department of Biology and Co-Director of the Center for Comparative and Evolutionary Biology of Hearing at the University of Maryland, College Park.
Vertebrates --- Hair cells. --- Physiology. --- Cells of Corti --- Cochlear hair cells --- Corti's cells --- Corti's organ --- Mechanoreceptors --- Neurobiology. --- Otorhinolaryngology. --- Vertebrates. --- Life sciences. --- Biological and Medical Physics, Biophysics. --- Life Sciences, general. --- Biosciences --- Sciences, Life --- Science --- Vertebrata --- Chordata --- Ear, nose, and throat diseases --- ENT diseases --- Otorhinolaryngology --- Medicine --- Neurosciences --- Biophysics. --- Biological physics. --- Biological physics --- Biology --- Medical sciences --- Physics
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The sensory hair cells in the inner ear and vestibular system convert mechanical stimuli, sound and motion into neural activity that is responsible for the sensations of hearing, motion and head position. In mammals, the loss of hair cells from acoustic overstimulation, ototoxic drugs and aging is irreversible, leading to a permanent loss of function. However, it is now clear that hair cells in other vertebrates are capable of regenerating and recovering partial or complete function. Moreover, partially damaged hair cells can undergo self-repair or be protected from traumatic insults by external compounds. Hair Cell Regeneration, Repair, and Protection provides a comprehensive survey of what is currently known about the regeneration, repair and protection of sensory hair cells and subsequent recovery of function in the auditory and vestibular system. The aim is to provide graduate students, postdoctoral fellows, clinicians and scientists in related disciplines with the biological bases of hair cells and with an understanding of the factors that contribute to their regeneration and repair. Table of Contents: Overview: Regeneration and repair Richard J. Salvi Morphological Correlates of Regeneration and Repair in the Inner Ear Jason R. Meyers and Jeffrey T. Corwin The recovery of function in the avian auditory system following ototrauma James C. Saunders and Richard J. Salvi Functional recovery following hair cell regeneration in birds Robert J. Dooling, Micheal L. Dent, Amanda M. Lauer, and Brenda M. Ryals Hair cell regeneration: Mechanisms guiding cellular proliferation and differentiation Elizabeth C. Oesterle and Jennifer S. Stone Protection and repair of inner ear sensory cells Andrew Forge and Thomas R. Van De Water Gene arrays, cell lines, stem cells, and sensory regeneration in mammalian ears Marcelo N. Rivolta and Matthew C. Holley About the editors: Richard J. Salvi, Center for Hearing and Deafness, University of Buffalo, NY. Arthur N. Popper is Professor in the Department of Biology and Co-Director of the Center for Comparative and Evolutionary Biology of Hearing at the University of Maryland, College Park. Richard R. Fay is Director of the Parmly Hearing Institute and Professor of Psychology at Loyola University of Chicago.
Hair cells. --- Hair cells --- Regeneration. --- Regeneration (Biology) --- Cells of Corti --- Cochlear hair cells --- Corti's cells --- Corti's organ --- Mechanoreceptors --- Neurobiology. --- Human physiology. --- Neurosciences. --- Human Physiology. --- Neural sciences --- Neurological sciences --- Neuroscience --- Medical sciences --- Nervous system --- Human biology --- Physiology --- Human body --- Neurosciences
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This book presents the latest findings in mechanosensitive ion channel research compiled by a number of internationally recognized experts in the field of mechanosensitivity, specializing in mechanosensitive or mechanically gated ion channels and the underlying mechanosensitive signaling cascades. ""Mechanosensitivity in Cells and Tissues: Mechanosensitive Ion Channels"" defines and discusses key problems of cellular mechanobiology, describing the methods for studying mechanosensitive ion channels, the role of lipid bilayer mechanics in mechanosensation, and the molecular organization, physiol
Ion channels. --- Mechanoreceptors. --- Ion channels --- Mechanoreceptors --- Ion Channels --- Mechanotransduction, Cellular --- Membrane Glycoproteins --- Biophysical Processes --- Signal Transduction --- Membrane Transport Proteins --- Sensory Receptor Cells --- Carrier Proteins --- Biochemical Processes --- Biophysical Phenomena --- Peripheral Nervous System --- Cell Physiological Processes --- Membrane Proteins --- Neurons, Afferent --- Physical Processes --- Proteins --- Chemical Processes --- Physical Phenomena --- Neurons --- Cell Physiological Phenomena --- Biochemical Phenomena --- Nervous System --- Amino Acids, Peptides, and Proteins --- Phenomena and Processes --- Chemical Phenomena --- Cells --- Anatomy --- Chemicals and Drugs --- Cytology --- Biology --- Health & Biological Sciences --- Mechanicoreceptors --- Channels, Ion --- Life sciences. --- Cell biology. --- Animal physiology. --- Biomathematics. --- Biophysics. --- Biological physics. --- Life Sciences. --- Cell Biology. --- Animal Physiology. --- Biophysics and Biological Physics. --- Physiological, Cellular and Medical Topics. --- Sensory receptors --- Biological transport, Active --- Ion-permeable membranes --- Membrane proteins --- Cytology. --- Physiology --- Biological and Medical Physics, Biophysics. --- Mathematics. --- Animal physiology --- Animals --- Cell biology --- Cellular biology --- Cytologists --- Mathematics --- Biological physics --- Medical sciences --- Physics
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