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Written by a leading expert on Aspirin-related research, this is the most comprehensive treaty of the history, pharmacological effects and clinical applications of one of the most successful drugs ever. The text is written with a wide audience in mind and to be readily understandable for clinicians, pharmacists, biomedical researchers and pharmacologists alike. This third completely revised edition contains the latest results of clinical and pharmacological research on Acetylsalicylic acid, addressing the multiple pharmacological properties of this famous drug with a balanced view on their translation into clinical practice, including prevention and treatment of cardiovascular diseases, thromboinflammation and colorectal cancer.
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Pharmacology. --- Pharmacologie --- Pharmacology --- Drug effects --- Medical pharmacology --- Medical sciences --- Chemicals --- Chemotherapy --- Drugs --- Pharmacy --- Physiological effect
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pharmacology --- clinical pharmacy --- Pharmacology --- Drug effects --- Medical pharmacology --- Medical sciences --- Chemicals --- Chemotherapy --- Drugs --- Pharmacy --- Physiological effect
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Drug Metabolism: Current Concepts Corina Ionescu and Mino R Caira Drug Metabolism: Current Concepts provides a comprehensive understanding of the processes that take place following ingestion of a medicinal agent or xenobiotic, with an emphasis on the crucial role of metabolism (biotransformation). How a sound knowledge of these phenomena is incorporated into the design of effective new drug candidates is also explained. The user-friendly text focuses on concepts rather than extraneous details and is supported by many illustrated examples of biotransformations as well as frequent references to current critical reviews and articles highlighting the nature of research objectives in this vibrant area of medicinal development. The final topic on strategies for drug design relies on the background provided by the rest of the book. The book includes chapters on ADME (drug absorption, distribution, metabolism and elimination) Pathways of biotransformation (Phase I and Phase II metabolic reactions) Enzymatic systems involved in biotransformation Induction and inhibition of drug-metabolising enzymes Factors that influence drug biotransformation The role of pharmacogenetics Drug-drug interactions and adverse reactions Strategies for drug design. This book is ideally suited as an advanced text for courses in drug metabolism for students of medicine, pharmacy, pharmacology, biochemistry; and for courses in drug design and drug delivery for students of medicinal chemistry. It is also appropriate for professional seminars or courses that relate to the fate of a drug in the body, drug interactions, adverse reactions and drug design.
Drugs --- Pharmacology. --- Metabolism. --- Drug effects --- Medical pharmacology --- Medical sciences --- Chemicals --- Chemotherapy --- Pharmacy --- Physiological effect --- Drug metabolism --- Pharmacokinetics
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Prodrugs are substances administered in an inactive form that is then metabolized in the body in vivo into the active compound. The rationale behind administering prodrugs is to optimize absorption, distribution, metabolism, and excretion of these drugs. Since first described in the 1950s, prodrugs continue to be a fertile area of research. There are a number of small pharmaceutical/biotech companies dedicated to using prodrugs for the delivery of older but problematic drugs as well as to developing broad-based prodrug technologies for application to new and future drugs. These volumes represent a comprehensive guide to prodrugs and will guide the reader through the current status of the prodrug concept and its many applications and to highlight its many successes in overcoming formulation and delivery of problematic drugs.
Pharmacology. --- Prodrugs. --- Drug effects --- Medical pharmacology --- Medical sciences --- Chemicals --- Chemotherapy --- Drugs --- Pharmacy --- Physiological effect --- Antibody-directed enzyme prodrug therapy
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Pharmacology --- Pharmacology. --- Drug effects --- Medical pharmacology --- Pharmacologies --- Pharmaceutical Preparations --- pharmacology --- Medical sciences --- Chemicals --- Chemotherapy --- Drugs --- Pharmacy --- Physiological effect
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Pharmacology --- Pharmacology. --- Ejournals --- UML. --- Drug effects --- Medical pharmacology --- Pharmacologies --- Pharmaceutical Preparations --- pharmacology --- Medical sciences --- Chemicals --- Chemotherapy --- Drugs --- Pharmacy --- Physiological effect
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The treatment of cancer has undergone dramatic evolutions in the past two decades and the provision of holistic care by a multidisciplinary team of specialists is emerging as the cornerstone of recent improvements in outcome. Accompanying this multidisciplinary approach is the increasing complexity of therapeutic agents and modalities utilized. Drugs in Cancer Care is a succinct, practical and user-friendly guide to commonly used drugs and non-surgical therapeutic modalities in oncology. This detailed yet concise handbook contains over 90 monographs of cancer care providing the information nee
Cancer --- Pharmacology. --- Drug effects --- Medical pharmacology --- Medical sciences --- Chemicals --- Chemotherapy --- Drugs --- Pharmacy --- Antineoplastic agents --- Chemotherapy. --- Physiological effect --- Treatment
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This volume provides a comprehensive outline of the current methods used to detect, characterize, and investigate Shiga toxin-producing E. coli (STEC) and Shiga toxins. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Shiga Toxin-Producing E. coli: Methods and Protocols aims to be a valuable resource for clinicians, epidemiologists, and researchers interested in STEC pathogenesis.
Pharmacology. --- Pathology. --- Disease (Pathology) --- Medical sciences --- Diseases --- Medicine --- Medicine, Preventive --- Drug effects --- Medical pharmacology --- Chemicals --- Chemotherapy --- Drugs --- Pharmacy --- Physiological effect
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This book provides a collection of microphysiological systems employed for chemical/drug screening and strategies to mimic various physiological conditions. Chapters guide readers through Organ-on-a-Chip( OoC) platforms such as liver, intestine, blood-brain barrier, kidney, vessels, cardiac and skeletal muscles, articular joint, human fat. Additional chapters detail microfabrication technologies used to fabricate OoC devices such as, standard photo- and soft-lithography, techniques to fabricate membranes, and industrial-oriented fabrication methods.Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary materials and reagents, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols. Authoritative and cutting-edge, Organ-On-a Chip: Methods and Protocols aims to be a useful practical guide to researches to help further their study in this field.
Biotechnology. --- Pharmacology. --- Drug effects --- Medical pharmacology --- Medical sciences --- Chemicals --- Chemotherapy --- Drugs --- Pharmacy --- Chemical engineering --- Genetic engineering --- Physiological effect
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