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Convertases are widely expressed activating enzymes involved in various physiological and pathological processes. The purpose of this book is to provide detailed and updated information on the role of these molecules in cancer. This book is the first to summarize current knowledge about the importance of protein precursors maturation by the convertases in tumor progression, angiogenesis and metastasis. In each chapter, the importance of the convertases in the activation of various cancer-related molecules including growth factors, adhesion molecules and proteases is discussed. Also this book covers the role of some convertases in the clinical setting. The book will be of interest to basic researchers as well as clinicians. It will also interest those working in the cancer research area and the pharmaceutical industry, who are looking for new strategies in cancer therapy. Finally, this book is also a useful reference for researchers and clinicians pursuing research on growth factors, adhesion molecules, proteases and their implications in the processes of tumor progression, angiogenesis and metastasis.

Cancer --- Enzyme inhibitors --- Carcinogenesis --- Treatment. --- Therapeutic use. --- Molecular aspects. --- Genetic aspects. --- Oncogenesis --- Pathogenesis of cancer --- Tumorigenesis --- Pathology --- Genetic toxicology --- Molecular carcinogenesis --- Pathology, Molecular --- Antagonists, Enzyme --- Enzyme antagonists --- Enzymes --- Inhibitors, Enzyme --- Metabolic inhibitors --- Chemical inhibitors --- Cancer therapy --- Cancer treatment --- Pathogenesis --- Antagonists --- Inhibitors --- Therapy --- Oncology. --- Oncology  . --- Chemistry. --- Cancer Research. --- Chemistry/Food Science, general. --- Physical sciences --- Tumors --- Cancer research. --- Cancer research

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Focuses on molecular aspects of the mechanisms involved in chemical, physical, and viral (biological) carcinogenesis. Areas of interest include, but are not limited to, the structure, expression, or function of genes or gene products associated with normal growth and differentiation and alterations in neoplasia; characterization of genes or gene products expressed in preneoplastic or neoplastic cells; molecular studies that define a specific function of a tumor-associated protein or its effects on cellular function; virtually all research on molecular aspects of oncogenes, tumor suppressor genes, and their gene products; carcinogenesis studies in transgenic mice; and research on human tumor viruses.

Carcinogenesis --- Cancérogenèse --- Molecular aspects --- Aspect moléculaire --- Périodiques. --- Molecular aspects. --- Molecular carcinogenesis --- Cancer --- Oncogenesis --- Pathogenesis of cancer --- Tumorigenesis --- Pathogenesis --- Pathology, Molecular --- Pathology --- Genetic toxicology --- Carcinogens --- Molecular Biology --- Biochemical Genetics --- Biology, Molecular --- Genetics, Biochemical --- Genetics, Molecular --- Molecular Genetics --- Biochemical Genetic --- Genetic, Biochemical --- Genetic, Molecular --- Molecular Genetic --- Genetic Phenomena --- Carcinogen --- Oncogen --- Oncogens --- Tumor Initiator --- Tumor Initiators --- Tumor Promoter --- Tumor Promoters --- Initiator, Tumor --- Initiators, Tumor --- Promoter, Tumor --- Promoters, Tumor --- Benzidines --- Carcinogens. --- Cancérogènes. --- Periodicals. --- Cancer causing agents --- Carcinogenic agents --- Hazardous substances

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Tumors can be induced by a variety of physical and chemical carcinogens. The resulting tumor cells are usually abnormal in their morphology and behavior and transmit their abnormalities to their daughter tumor cells. Most theories of the pathogenesis of tumors suggest that carcinogens in some way cause alterations either of the genomes or of inheritable patterns of gene expression in normal cells, which then cause morphological and behavioral changes. This volume presents a collection of articles aimed at the question by what genetic or epigenetic mechanisms carcinogens can cause morphological abnormalities of tumor cells. It includes reviews of cellular targets of known carcinogens, and presents varying viewpoints of how morphological abnormalities and the actions of carcinogens might be related. The volume will be of interest to all those who are involved in cancer research or in the prevention, diagnosis or management of tumors in humans or animals.

Cancer. --- Cancer cells. --- Carcinogenesis. --- Carcinogenesis - Molecular aspects. --- Carcinogens. --- Gene Expression Regulation, Neoplastic. --- Genomic Instability. --- Neoplasms. --- Carcinogenesis --- Cancer cells --- Cancer --- Gene Expression Regulation, Neoplastic --- Genomic Instability --- Carcinogens --- Genetics --- Neoplasms --- Gene Expression Regulation --- Diseases --- Noxae --- Biology --- Pathologic Processes --- Genetic Phenomena --- Mutation --- Genetic Processes --- Pathological Conditions, Signs and Symptoms --- Genetic Variation --- Phenomena and Processes --- Biological Science Disciplines --- Toxic Actions --- Chemical Actions and Uses --- Natural Science Disciplines --- Chemicals and Drugs --- Disciplines and Occupations --- Oncology --- Medicine --- Health & Biological Sciences --- Molecular aspects --- Pathophysiology --- Genetic aspects --- Molecular aspects. --- Pathophysiology. --- Genetic aspects. --- Cancer genetics --- Molecular carcinogenesis --- Medicine. --- Cancer research. --- Biomedicine. --- Cancer Research. --- Biomedicine general. --- Cancer genes --- Cells --- Pathology, Cellular --- Pathology, Molecular --- Oncology. --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Tumors --- Health Workforce --- Biomedicine, general. --- Cancer research --- Cancer Biology. --- Biomedical Research. --- Research. --- Biological research --- Biomedical research --- Cancers --- Carcinoma --- Malignancy (Cancer) --- Malignant tumors