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This book describes unusual cases of cutaneous lymphomas and is of special interest for clinicians and pathologists dealing with the vexing subject of cutaneous lymphoma. In addition to the case description, it gives the clinical, histological, and in most cases also the phenotypical features and the results of molecular techniques. A commentary puts the observations into the context of cutaneous lymphomas. Related papers are cited. The book will be especially helpful in cases which do not fit into the normal spectrum of cutaneous lymphomas. Rare entities of cutaneous lymphomas are demonstrated with high-quality pictures (4-color) and a concise text in an appealing format throughout the book. The new WHO/EORTC-Classification of Cutaneous lymphomas includes more than 30 entities of Cutaneous T-cell and Cutaneous B-cell lymphomas.

Lymphomas. --- Skin --- Tumors. --- Germinoblastomas --- Immunoblastomas --- Lymphoma --- Non-Hodgkin's lymphoma --- Reticulolymphosarcomas --- Sarcoma, Germinoblastic --- Sarcoma, Immunoblastic --- Lymphoproliferative disorders --- Reticulo-endothelial system --- Tumors --- Dermatology. --- Oncology  . --- Oncology. --- Medicine --- Diseases

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Lymphomas --- Lymphoma. --- Lymphomas. --- Germinoblastomas --- Immunoblastomas --- Lymphoma --- Non-Hodgkin's lymphoma --- Reticulolymphosarcomas --- Sarcoma, Germinoblastic --- Sarcoma, Immunoblastic --- Germinoblastoma --- Lymphoma, Malignant --- Reticulolymphosarcoma --- Germinoblastic Sarcoma --- Germinoblastic Sarcomas --- Lymphomas, Malignant --- Malignant Lymphoma --- Malignant Lymphomas --- Sarcomas, Germinoblastic --- Lymphoproliferative disorders --- Reticulo-endothelial system --- Lymphatic Diseases --- Hematologic Neoplasms --- Tumors

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Toll Receptors and the Renaissance of Innate Immunity Elizabeth H. Bassett and Tina Rich Overview n the last few pages of Immunology: The Science of Self-Nonself Discrimination Jan Klein ponders on what he would study if he were to start over in the lab. ^ Dismissing the I antibody, MHC, the T-cell and parasitology, he considers instead the phylogeny of immune reactions, particularly in ancient phyla. As for a favored cell he chooses the macrophage. Describ­ ing it as a ^^MddchenfUr alles," (all purpose kitchen maid) Klein believed that this immunocyte still had secrets to reveal. Toll-Like Receptor (TLR) biology would prove to be one of these secrets. Analyses of the evolution of these receptors (Tolls and TLRs) have also helped us to rethink immune system phylogeny. In the first part of this chapter the history of the discovery of Toll and TLR biology is described. The evolution of the TLR genes and theories of immune function are covered in later sections. The remainder of this book presents work from nine groups active in the field. In the first chapter, "The Function of Toll-Like Receptors", Zlatko Dembic sets the stage by introducing us to many of the components of the immune system and their relationships vis a vis Toll receptors. Zlatko finishes his chapter with a discussion about current immune system models and contributes his own 'integrity model'. Work from the laboratory of Nicholas Gay follows this in "Structures and Motifs Involved in Toll Signaling".

B cells --- Macrophages --- Dendritic cells --- Natural immunity. --- Cellular immunity. --- Receptors. --- Cell-mediated immunity --- Cellular immunology --- Clonal selection theory --- Immune response --- Immunity --- Disease resistance --- Host resistance --- Innate immunity --- Innate resistance --- Native immunity --- Natural resistance --- Nonspecific immunity --- Resistance to disease --- Follicular dendritic cells --- Interdigitating cells --- Antigen presenting cells --- Lymphoid tissue --- Histiocytes --- Mononuclear phagocytes --- Connective tissue cells --- Killer cells --- Phagocytes --- Reticulo-endothelial system --- B lymphocytes --- Bone marrow derived cells --- Bursa equivalent cells --- Lymphocytes --- Cytology. --- Immunology. --- Cell Biology. --- Immunobiology --- Life sciences --- Serology --- Cell biology --- Cellular biology --- Biology --- Cells --- Cytologists --- Cell biology.

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Lymphomas --- Leukemia --- Leukemia. --- Lymphomas. --- Lymphoma --- Multiple Myeloma --- Kahler Disease --- Myeloma, Multiple --- Myeloma-Multiple --- Myelomatosis --- Plasma Cell Myeloma --- Myeloma, Plasma-Cell --- Cell Myeloma, Plasma --- Cell Myelomas, Plasma --- Disease, Kahler --- Multiple Myelomas --- Myeloma Multiple --- Myeloma, Plasma Cell --- Myeloma-Multiples --- Myelomas, Multiple --- Myelomas, Plasma Cell --- Myelomas, Plasma-Cell --- Myelomatoses --- Plasma Cell Myelomas --- Plasma-Cell Myeloma --- Plasma-Cell Myelomas --- Germinoblastoma --- Lymphoma, Malignant --- Reticulolymphosarcoma --- Sarcoma, Germinoblastic --- Germinoblastic Sarcoma --- Germinoblastic Sarcomas --- Germinoblastomas --- Lymphomas, Malignant --- Malignant Lymphoma --- Malignant Lymphomas --- Reticulolymphosarcomas --- Sarcomas, Germinoblastic --- Immunoblastomas --- Non-Hodgkin's lymphoma --- Sarcoma, Immunoblastic --- Leucaemia --- Leucemia --- Leucocythaemia --- Leucocythemia --- Leucosis --- Leukaemia --- Leukosis --- Myeloma Proteins --- Lymphatic Diseases --- Hematologic Neoplasms --- Lymphoproliferative disorders --- Reticulo-endothelial system --- Anemia --- Cancer --- Leucocytosis --- Preleukemia --- Tumors --- Health Sciences --- Oncology --- leukemie --- Lymphoma. --- Multiple Myeloma.

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Autophagy is a fundamental biological process that enables cells to autodigest their own cytosol during starvation and other forms of stress. It has a growing spectrum of acknowledged roles in immunity, aging, development, neurodegeneration, and cancer biology. An immunological role of autophagy was first recognized with the discovery of autophagy’s ability to sanitize the cellular interior by killing intracellular microbes. Since then, the repertoire of autophagy’s roles in immunity has been vastly expanded to include a diverse but interconnected portfolio of regulatory and effector functions. Autophagy is an effector of Th1/Th2 polarization; it fuels MHC II presentation of cytosolic (self and microbial) antigens; it shapes central tolerance; it affects B and T cell homeostasis; it acts both as an effector and a regulator of Toll-like receptor and other innate immunity receptor signaling; and it may help ward off chronic inflammatory disease in humans. With such a multitude of innate and adaptive immunity functions, the study of autophagy in immunity is one of the most rapidly growing fields of contemporary immunological research. This book introduces the reader to the fundamentals of autophagy, guides a novice and the well-informed reader alike through different immunological aspects of autophagy as well as the countermeasures used by highly adapted pathogens to fight autophagy, and provides the expert with the latest, up-to-date information on the specifics of the leading edge of autophagy research in infection and immunity.

Autophagic vacuoles. --- Autophagy. --- Cellular immunity. --- Immunity, Innate. --- Infection -- immunology. --- Cellular immunity --- Autophagic vacuoles --- Infection --- Immunity, Innate --- Autophagy --- Immunity --- Bacterial Infections and Mycoses --- Cell Death --- Phagocytosis --- Immune System Phenomena --- Cell Physiological Processes --- Diseases --- Endocytosis --- Phenomena and Processes --- Cell Physiological Phenomena --- Microbiology & Immunology --- Biology --- Health & Biological Sciences --- Phagocytosis. --- Cell-mediated immunity --- Cellular immunology --- Medicine. --- Immunology. --- Medical microbiology. --- Virology. --- Biomedicine. --- Medical Microbiology. --- Microbiology --- Immunobiology --- Life sciences --- Serology --- Clinical sciences --- Medical profession --- Human biology --- Medical sciences --- Pathology --- Physicians --- Antigen-antibody reactions --- Immune response --- Immunology --- Phagosomes --- Pinocytosis --- Reticulo-endothelial system --- Tuftsin --- Clonal selection theory --- Medical virology. --- Microbiology. --- Microbial biology --- Microorganisms --- Medical microbiology --- Virology --- Virus diseases