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Rb and Tumorigenesis examines how recent advances have demonstrated the interaction of Rb with chromatin remodeling enzymes. This new title explores the potential roles of these interactions in Rb functions and provides some evidence that distinct Rb co-repressor may target different genes in different phases of the cell cycle.

Retinoblastoma. --- Neuroblastoma. --- Hutchinson's syndrome --- Pepper's syndrome --- Sympathicoblastoma --- Cancer in children --- Nervous system --- Sarcoma --- Glioblastoma, Retinal --- Glioma, Retinal --- Neuroblastoma, Retinal --- Retinal glioblastoma --- Retinal glioma --- Retinal neuroblastoma --- Neuroblastoma --- Pseudoglioma --- Retina --- Cancer --- Cytology. --- Medicine. --- Immunology. --- Cell Biology. --- Molecular Medicine. --- Immunobiology --- Life sciences --- Serology --- Clinical sciences --- Medical profession --- Human biology --- Medical sciences --- Pathology --- Physicians --- Cell biology --- Cellular biology --- Biology --- Cells --- Cytologists --- Health Workforce --- Cell biology. --- Molecular biology. --- Molecular biochemistry --- Molecular biophysics --- Biochemistry --- Biophysics --- Biomolecules --- Systems biology

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Neuroblastoma is a medical enigma. As a childhood neoplasm arising from neural crest cells, it is characterized by diverse clinical behaviors ranging from spontaneous remission to rapid tumor progression and death. Although clinical outcome can be predicted to a large extent by the stage of disease and the age at diagnosis, an in-depth understanding of its clinico-pathological behavior, now greatly aided by sophisticated molecular genetic profiling, will improve diagnostic precision and refine risk-based therapies. Comprehensive international efforts have advanced our understanding of tumor biology and improved the clinical management of children with neuroblastoma. This book reviews our current understanding of the genes and biological pathways that contribute to neuroblastoma pathogenesis, modern risk-based treatment approaches for these patients, and recent advances in biologically based therapy. It provides a concise up-to-date reference for practitioners, students, and researchers.

Neuropathology --- chirurgie --- Oncology. Neoplasms --- Surgery --- oncologie --- pediatrie --- hersenen --- Paediatrics --- Neuroblastoma --- Tumoren. --- Kindergeneeskunde. --- Medicine. --- Oncology. --- Neurology. --- Pediatrics. --- Pediatric surgery. --- Medicine & Public Health. --- Pediatric Surgery. --- Tumors in children. --- Children --- Diseases. --- Childhood diseases --- Children's diseases --- Diseases of children --- Juvenile diseases --- Pediatrics --- Pediatric oncology --- Diseases --- Oncology  . --- Surgery. --- Surgery, Primitive --- Medicine --- Nervous system --- Neuropsychiatry --- Pediatric medicine --- Tumors --- Health and hygiene --- Neurology . --- Pediatric surgery --- Surgery, Pediatric --- Treatment