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Adipocytes are a major component of the bone marrow, accounting for up to 70% of total bone marrow volume in healthy humans. Indeed, this bone marrow adipose tissue (often referred to as ‘MAT’ or ‘BMAT’) accounts for at least 5% of total adipose tissue mass in lean, healthy humans, suggesting a role in normal physiology and development. Bone marrow adiposity further increases with ageing and in diverse clinical conditions, including major public health challenges such as osteoporosis. Yet despite this abundance and compelling clinical potential, bone marrow adipocytes have received surprisingly little attention from the biomedical research community. Thankfully, this is now beginning to change. Research over the past decade has begun to increase our knowledge of BMAT, including the conditions associated with altered bone marrow adiposity and the potential physiological and pathological functions of bone marrow adipocytes. The articles within this e-Book highlight many of these recent developments, underscoring our increasing knowledge of BMAT formation and function; showcasing emerging techniques for basic and clinical BMAT analysis; and highlighting key questions and future directions for this burgeoning and increasingly diverse field. The editors would like to express their thanks to the authors for contributing the articles within this e-Book; to the senior editors at Frontiers in Endocrinology for their guidance; and to the staff at Frontiers for their helpful input throughout.

bone

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An evidence-based resource for effectively managing challenging orthopaedic infections Orthopaedic infections represent common, potentially devastating, and sometimes fatal complications that can occur after any surgery. Infections associated with orthopaedic trauma are especially prevalent, and there is an increasing incidence of bone infections linked to a greater number of joint arthroplasties being performed annually. Management of Orthopaedic Infections: A Practical Guide by renowned orthopaedic surgeon and researcher Antonia Chen is a practical clinical reference to assist clinicians in the diagnosis and treatment of challenging infections spanning the entire orthopaedic specialty. The step-by-step guide covers frequent organisms found in orthopaedics, molecular methods to improve organism determination, different antibiotic formulations to treat infections, various irrigation solutions used during surgery, and surgical dressings. Ten concise chapters cover surgical management of common infectious pathologies, including osteomyelitis, septic joint, periprosthetic joint infection, open fractures and infected nonunions, spine infections, and graft infections. Key Features High-quality figures and instructional surgical videos illustrate and enhance understanding of important concepts Multiple tables provide quick references and easy access to salient information needed to manage the care of patients with orthopaedic infections Practical tips from clinicians with vast expertise inform optimal treatment strategies and enable improved outcomes This is a must-have pocket resource for medical students, residents, fellows, and practitioners in orthopaedic surgery, as well as allied health personnel.

Bone diseases.

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Bone Cancer: Bone Sarcomas and Bone Metastases - From Bench to Bedside, Third Edition comprehensively investigates key discoveries in the field of bone biology. New aspects of bone cancer biology are treated in new chapters covering exosomes, autophagy, and metabolism. These have led to the development of entirely new areas for investigation, such as therapies which combine surgery and biological approaches. The Third Edition expands on the original overview of bone cancer development (physiology and pathophysiology), with 40% new material. Each chapter has been written by internationally recognized specialists on the bone cancer microenvironment, bone metastases, osteoclast biology in bone cancer, proteomics, bone niche, circulating tumor cells, and clinical trials. Given the global prevalence of breast and prostate cancers, knowledge of bone biology has become essential for everyone within the medical and cancer research communities. Bone Cancer: Bone Sarcomas and Bone Metastases - From Bench to Bedside continues to offer the only translational reference to cover all aspects of primary bone cancer and bone metastases. This revision opens the door to myeloma with two short chapters dedicated to this bone-associated disease.

Bone Cancer. --- Bone Neoplasms --- therapy. --- Bones --- Bone metastasis. --- Bone Neoplasms. --- Cancer. --- Cancer of the Bone --- Neoplasms, Bone --- Bone Cancer --- Cancer of Bone --- Bone Neoplasm --- Neoplasm, Bone --- Metastatic bone cancer --- Metastatic bone disease --- Osseous metastasis --- Skeletal metastasis --- Metastasis --- Cancer

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""Ice skates made from animal bones were used in Europe for millennia before metal-bladed skates were invented. Archaeological sites have yielded thousands of examples, some of them dating to the Bronze Age. They are often mentioned in popular books on the Vikings and sometimes appear in children's literature. Even after metal skates became the norm, people in rural areas continued to use bone skates into the early 1970s. Today, bone skates help scientists and re-enactors understand migrations and interactions among ancient peoples. This book explains how to make and use them and chronicles their history, from their likely invention in the Eurasian steppes to their disappearance in the modern era."-Provided by publisher"--

Skates --- Bone implements --- Bone skates. --- History.

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Bone Cancer, 2nd Edition comprehensively investigates key discoveries in the field of bone biology over the last five years that have led to the development of entirely new areas for investigation, such as therapies which combine surgery and biological approaches. The Second Edition expands on the original overview of bone cancer development (physiology and pathophysiology), with key chapters from the first edition, and offers numerous new chapters describing the new concepts of bone cancer biology and therapy, for both primary bone tumors as well as bone metastases. Each chapter has been written by internationally recognized specialists on the bone cancer microenvironment, bone metastases, osteoclast biology in bone cancer, proteomics, bone niche, circulating tumor cells, and clinical trials. Given the global prevalence of breast and prostate cancers, knowledge of bone biology has become essential for everyone within the medical and cancer research communities. Bone Cancer continues to offer the only translational reference to cover all aspects of primary bone cancer and bone metastases - from bench to bedside: development (cellular and molecular mechanisms), genomic and proteomic analyses, clinical analyses (histopathology, imaging, pain monitoring), as well as new therapeutic approaches and clinical trials for primary bone tumors and bone metastases. Presents a comprehensive, translational source for all aspects of primary bone cancer and bone metastases in one reference work Provides a common language for cancer researchers, bone biologists, oncologists, and radiologists to discuss bone tumors and how bone cancer metastases affects each major organ system Offers insights to research clinicians (oncologists and radiologists) into understanding the molecular basis of bone cancer, leading to more well-informed diagnoses and treatment of tumors and metastases Offers insights to bone biologists into how clinical observations and practices can feed back into the research cycle and, therefore, can contribute to the development of more targeted genomic and proteomic assays.

Bones --- Bone metastasis. --- Cancer. --- Bone Neoplasms. --- Cancer --- Treatment. --- Bone Neoplasms --- Cancer of the Bone --- Neoplasms, Bone --- Bone Cancer --- Cancer of Bone --- Bone Neoplasm --- Neoplasm, Bone --- Metastatic bone cancer --- Metastatic bone disease --- Osseous metastasis --- Skeletal metastasis --- Metastasis