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Acute diarrheal diseases (ADD) are important causes of morbidity and mortality worldwide. ADD includes, among others, cholera, shigellosis, and rotavirus diarrhea. These diseases are known to cause sporadic epidemics. Cholera and shigellosis are known to even cause pandemics. The treatments of these two diseases have been simplified with the advent of oral rehydration therapy and effective antibiotics. However, development of drug resistance poses tremendous therapeutic challenges. This book includes chapters on new methods of classification of dehydration and this information will provide a better classification method of dehydration. Epilepsy and its association with acute diarrhea is a new area for research. Prevention of acute diarrhea in school children and treatment with herbal medicines are important areas to pursue further. The readers will find herein new concepts in diarrheal disease research and management.
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Diarrhea in children. --- Diarrhea in children --- Etiology.
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Clostridium diseases. --- Clostridium difficile. --- Diarrhea.
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This textbook provides a practical and comprehensive account of the management of diarrhoea and constipation in the elderly. These common disorders in the elderly are not only a burden in themselves but are often manifestations of a more serious underlying illness: thus effective diagnosis and treatment are essential to improve quality of life. Many important conditions are associated with diarrhoea. The text includes updates on pathogenesis, diagnosis and treatment, and highlights the vulnerability of the elderly in regard to acquiring diarrhoea and its complications. The aetiology of diarrhoea is explained, including infections of the gastrointestinal tract, and systemic diseases of which diarrhoea is a manifestation. Diverse disciplines are spanned: from immunology and physiology to microbiology, nutrition and psychiatry. The aetiology, diagnosis and treatment of constipation are dealt with, emphasising practical management issues. The book is aimed at geriatricians, general practitioners and allied health workers.
Diarrhea in old age. --- Constipation in old age. --- Geriatric constipation --- Older people --- Geriatric diarrhea --- Diseases
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Pregnancy --- Diarrhea, Infantile --- Diarrhea in children --- Lactation --- Nutritional aspects. --- Gestation --- Cholera infantum --- Diarrhea in infants --- Infantile diarrhea --- Milk --- Milk secretion --- Secretion --- Conception --- Physiology --- Reproduction --- Infants --- Milk yield --- Breastfeeding --- Breast milk --- Prolactin --- Pediatric gastroenterology --- Diseases
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Celiac disease. --- Coeliac disease --- Diarrhea --- Digestive organs --- Malabsorption syndromes --- Diseases
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One of the top four contributors to the global burden of disease is diarrheal infections. Intestinal parasites are major causes of morbidity and mortality associated with diarrheal diseases in both the developed and developing world. Amebiasis is responsible for 50 million cases of invasive disease and 70,000 deaths annually in the world. Giardiasis has an estimated worldwide prevalence of 280 million cases annually. In developed countries, Giardia lamblia infects about 2% of adults and 6-8% of children. The prevalence of G. lamblia infection is generally higher in developing countries, ranging from 3% to 90%. Furthermore, giardial infections contribute substantially to the 2.5 million annual deaths from diarrheal disease. In Asia, Africa, and Latin America, about 500,000 new giardiasis cases are reported each year. Cryptosporidium accounts for 20% and 9% of diarrheal episodes in children in developing and developed countries, respectively. Infection with Cryptosporidium can be chronic and especially debilitating in immunosuppressed individuals and malnourished children. A recent study to measure disease burden, based on disability-adjusted life years (DALYs), found that cryptosporidiosis and amebiasis produce about 10.6 million DALYs. This exceeds the DALYs of any helminth infection currently being targeted by the World Health Organization for preventive chemotherapy. Because of its link with poverty, Giardia and Cryptosporidium were included in the WHO Neglected Diseases Initiative in 2004. E. histolytica, G. lamblia, and C. parvum have been listed by the National Institutes of Health (NIH) as category B priority biodefense pathogens due to low infectious dose and potential for dissemination through compromised food and water supplies in the United States. Despite the prevalence of amebiasis, giardiasis, and cryptosporidiosis there are no vaccines or prophylactic drugs. The first-line drugs for invasive amebiasis and giardiasis chemotherapy are nitroimidazoles, with the prototype, metronidazole, being the most common drug used worldwide. Metronidazole has been shown to be both mutagenic in a microbiological system and carcinogenic to rodents, and frequently causes gastrointestinal side effects. In spite of the efficacy of nitroimidazole drugs, treatment failures in giardiasis occur in up to 20% of cases. Clinical resistance of G. lamblia to metronidazole is proven and cross resistance is a concern with all commonly used antigiardial drugs. Nitazoxanide, the only FDA-approved drug for the treatment of cryptosporidiosis, is effective in the treatment of immunocompetent patients and partially effective for immunosuppressed patients. Therefore, it is critical to search for more effective drugs to treat amebiasis, giardiasis, and cryptosporidiosis. This Research Topic for Frontiers in Microbiology will explore the recent progress in drug development for parasitic diarrheal diseases. This includes an understanding of drug resistance mechanisms. We would also welcome submissions on the drug development for other diarrheal parasites. We hope that this research topic will include a comprehensive survey of various attempts by the parasitology research community to create effective drugs for these diseases.
Cryptosporidium --- parasite --- Giardia --- Entamoeba --- diarrhea --- chemotherapy --- protozoa --- drug
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First published in 1998, this book contributes to our understanding of emergent and resurgent infectious diseases and health ecology in developing areas through detailed spatial and temporal analysis of recent cholera and bacillary dysentery epidemics in Mozambique. The book examines the influence of environmental, demographic and socio-economic changes on the nature and context of cholera and bacillary dysentery. It provides a detailed background to the two diseases based on their ecology and contemporary status in human communities together with analysis of extensive primary field data centered on three key urban areas in central Mozambique. Influences are weighed up against factors relating to the individual ecologies of the different pathogens, primary subsistence, and the impacts of Mozambique's history of conflict and development policies on human vulnerability. The extensive case study material is used to provide clear indications of appropriate ways forward in the field of environmental health management.
Diarrhea --- Communicable diseases --- Environmentally induced diseases --- Medical policy --- Environmental aspects
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Celiac disease (CD) is an immune-mediated enteropathy triggered by the ingestion of gluten-containing grains (including wheat, rye and barley) in genetically susceptible individuals. CD can manifest itself with a previously unappreciated range of clinical presentations, including the typical malabsorption syndrome and a spectrum of symptoms potentially affecting any organ system. Since CD often presents in an atypical or even silent manner, many cases remain undiagnosed and carry the risk of long-term complications, including anemia and other hematological complications, osteoporosis, neurological complications or cancer. The high prevalence of the disease and its variety of clinical outcomes raise several interesting questions. This book covers most of the aforementioned controversial and yet unresolved topics by including the contributions of experts in CD.What the reader will surely find stimulating about this book is not only its exhaustive coverage of our current knowledge of CD, but also provocative new concepts in disease pathogenesis and treatment.
Celiac disease. --- Coeliac disease --- Diarrhea --- Digestive organs --- Malabsorption syndromes --- Diseases --- Hepatology
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