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"Nutritional Epigenomics offers a comprehensive overview of nutritional epigenomics as a mode of study, along with nutrition's role in the epigenomic regulation of disease, health and developmental processes. Here, an expert team of international contributors introduces readers to nutritional epigenomic regulators of gene expression, our diet's role in epigenomic regulation of disease and disease inheritance, caloric restriction and exercise as they relate to recent epigenomic findings, and the influence of nutritional epigenomics over circadian rhythms, aging and longevity, and fetal health and development, among other processes. Disease specific chapters address metabolic disease (obesity and diabetes), cancer, and neurodegeneration, among other disorders."--Provided by publisher.

Nutrition --- Genetic aspects. --- Epigenomics. --- Nutritional Physiological Phenomena --- Epigenesis, Genetic. --- Genome, Human. --- genetics. --- Human Genome --- Genomes, Human --- Human Genomes --- Epigenetic Process --- Epigenetics Processes --- Epigenetic Processes --- Genetic Epigenesis --- Process, Epigenetic --- Processes, Epigenetic --- Processes, Epigenetics --- Epigenome --- DNA Methylation --- Epigenetics --- Epigenetic --- Epigenomic --- Genetics

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The term epigenetics describes regulatory and information storing mechanisms of specific genes that do not involve any change of their DNA sequence. Epigenetics is closely related to the extensively folded state, in which the genome is packaged, known as chromatin. New genomic tools nowadays allow the genome-wide assessment of, for example, chromatin states and DNA modifications, and led to the discovery of unexpected new epigenetic principles, such as epigenomic memory. This was the start of the field of epigenomics, the relation of which to human health and disease is discussed in this textbook. This book aims to summarize, in a condensed form, the role of epigenomics in defining chromatin states that are representative of active genes (euchromatin) and repressed genes (heterochromatin). Moreover, this book discusses the principles of gene regulation, chromatin stability, genomic imprinting and the reversibility of DNA methylation and histone modifications. This information should enable a better understanding of cell type identities and will provide new directions for studies of, for example, cellular reprograming, the response of chromatin to environmental signals and epigenetic therapies that can improve or restore human health. In order to facilitate the latter, we favor a high figure-to-text ratio following the rule “a picture tells more than thousand words”. The content of the book is based on the lecture course “Molecular Medicine and Genetics” that is given by one of us (C. Carlberg) in different forms since 2002 at the University of Eastern Finland in Kuopio. Thematically, this book is located between our textbooks “Mechanisms of Gene Regulation” (ISBN 978-94-017-7741-4) and “Nutrigenomics” (ISBN 978-3-319-30415-1), studying of which may also be interesting to our readers. The book is sub-divided into three sections and 13 chapters. Following the Introduction (section A), section B will explain the molecular basis of epigenomics, while section C will provide examples for the impact of epigenomics in human health and disease. The lecture course is primarily designed for Master level students of biomedicine, but is also frequented by PhD students as well as by students of other bioscience disciplines. Besides its value as a textbook, Human Epigenomics will be a usefull reference for individuals working in biomedicine.

Medicine. --- Human genetics. --- Molecular biology. --- Biomedicine. --- Human Genetics. --- Molecular Medicine. --- Genetics --- Heredity, Human --- Human biology --- Physical anthropology --- Clinical sciences --- Medical profession --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Health Workforce --- Epigenomics. --- Gene Expression Regulation. --- Genome, Human. --- Human Genome --- Genomes, Human --- Human Genomes --- Expression Regulation, Gene --- Regulation, Gene Action --- Regulation, Gene Expression --- Gene Action Regulation --- Regulation of Gene Expression --- RNAi Therapeutics --- Gene Regulatory Networks --- Epigenetics --- Epigenetic --- Epigenomic --- Medical genetics. --- Molecular biochemistry --- Molecular biophysics --- Biochemistry --- Biophysics --- Biomolecules --- Systems biology

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"Creating Future People offers readers a fast-paced primer on how new genetic technologies will enable parents to influence the traits of their children, including their intelligence, moral capacities, physical appearances, and immune systems. It deftly explains the science of gene editing and embryo selection, and raises the central moral questions with colorful language and a brisk style. Jonathan Anomaly takes seriously the diversity of preferences parents have, and the limits policymakers face in regulating what could soon be a global market for reproductive technology. He argues that once embryo selection for complex traits happens it will change the moral landscape by altering the incentives available to parents. All of us will take an interest in the traits everyone else selects, and this will present coordination problems that previous writers on genetic enhancement have failed to consider. Anomaly navigates difficult ethical issues with vivid language and scientifically-informed speculation about how genetic engineering will transform humanity. Key Features: Offers clear explanations of scientific concepts Explores important moral questions without academic jargon Brings discoveries from different fields together to give us a sense of where humanity is headed"--

Genetic engineering --- Genetic Engineering. --- Genetic Engineering --- Organisms, Genetically Modified. --- Genome, Human. --- Moral and ethical aspects. --- ethics. --- Human Genome --- Genomes, Human --- Human Genomes --- GMO Organism --- GMO Organisms --- Genetically Engineered Organisms --- Genetically Modified Organism --- Modified Organism, Genetically --- Organism, Genetically Modified --- Organism, Transgenic --- Organisms, Genetically Engineered --- Genetically Modified Organisms --- Organisms, Transgenic --- Transgenic Organisms --- Transgenes --- Food, Genetically Modified --- Engineering, Genetic --- Intervention, Genetic --- Genetic Intervention --- Genetic Interventions --- Interventions, Genetic --- Biotechnology --- Cloning, Molecular --- DNA, Recombinant --- Industrial Microbiology --- Artificial Gene Fusion --- Organisms, Genetically Modified --- Animals, Genetically Modified --- Plants, Genetically Modified --- Philosophy;Ethics and moral philosophy;Genetics (non-medical)

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Describes the important role that epidemiologic methods play in the continuum from gene discovery to the development and application of genetic tests. It proceeds systematically from the fundamentals of genome technology and gene discovery, to epidemiologic approaches to gene characterization in the population, to the evaluation of genetic tests and their use in health services. These methodologic approaches are then illustrated with several disease-specific case studies.

Genetic disorders --- Medical genetics --- Genomics. --- Genetics, Medical --- Genetic Predisposition to Disease --- Genetic Diseases, Inborn --- Genome, Human. --- Genetic Testing --- Epidemiologic Research Design. --- Genetic Screening --- Predictive Genetic Testing --- Predictive Testing, Genetic --- Testing, Genetic Predisposition --- Genetic Predisposition Testing --- Genetic Predictive Testing --- Genetic Screenings --- Genetic Testing, Predictive --- Predisposition Testing, Genetic --- Screening, Genetic --- Screenings, Genetic --- Testing, Genetic --- Testing, Genetic Predictive --- Testing, Predictive Genetic --- Prenatal Diagnosis --- Preimplantation Diagnosis --- Cytogenetic Analysis --- Molecular Diagnostic Techniques --- Databases, Genetic --- Databases, Nucleic Acid --- Genetic Privacy --- Human Genome --- Genomes, Human --- Human Genomes --- Comparative Genomics --- Comparative Genomic --- Genomic, Comparative --- Genomics, Comparative --- Human Genome Project --- Genome --- Genome research --- Genomes --- Molecular genetics --- Clinical genetics --- Diseases --- Heredity of disease --- Human genetics --- Medical sciences --- Pathology --- Congenital diseases --- Disorders, Genetic --- Disorders, Inherited --- Genetic diseases --- Hereditary diseases --- Inherited diseases --- Design, Epidemiologic Research --- Designs, Epidemiologic Research --- Epidemiologic Research Designs --- Epidemiological Research Design --- Research Design, Epidemiologic --- Research Designs, Epidemiologic --- Design, Epidemiological Research --- Designs, Epidemiological Research --- Epidemiological Research Designs --- Research Design, Epidemiological --- Research Designs, Epidemiological --- Epidemiology. --- Methodology. --- methods. --- epidemiology. --- diagnosis --- Research --- Genetic aspects --- Genomics --- Epidemiology --- Methodology