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Because of its marked capacity to regenerate and the ability of chemical carcinogens and viruses to ready transform hepatocytes, the liver has been used extensively as a model for investigating the molecular mechanisms of cellular proliferation and carcinogenesis. Recently, striking advances have occured in the understanding of hepatocyte growth regulation and the manner in which chemical agents and viruses alter these normal growth regulatory pathways in liver carcinogenesis. This explosion of information has occured in a multitude of research disciplines. This book brings together current fin
Liver. --- Liver Neoplasms. --- Liver Regeneration. --- Liver--Cancer. Liver--Regeneration. Pathology, Molecular. Liver--Molecular aspects. Liver Regeneration. Liver Neoplasms--genetics. --- Pathology, Molecular. --- Liver --- Pathology, Molecular --- Liver Regeneration --- Genetics --- Liver Neoplasms --- Biology --- Digestive System Neoplasms --- Liver Diseases --- Regeneration --- Digestive System Processes --- Digestive System Diseases --- Digestive System Physiological Phenomena --- Neoplasms by Site --- Biological Processes --- Biological Science Disciplines --- Neoplasms --- Biological Phenomena --- Diseases --- Digestive System and Oral Physiological Phenomena --- Natural Science Disciplines --- Phenomena and Processes --- Disciplines and Occupations --- Oncology --- Medicine --- Health & Biological Sciences --- Cancer --- Molecular aspects --- Cancer. --- Molecular aspects. --- Regeneration. --- Molecular pathology --- Hepatic regeneration --- Hepatocellular carcinoma --- Molecular biology --- Physiology, Pathological --- Abdomen --- Biliary tract
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Liver Regeneration: Basic Mechanisms, Relevant Models and Clinical Applications presents cutting-edge information on liver regeneration research through an integrated, systems-wide perspective. The book addresses discoveries on hepatic progenitor cells, liver regeneration after chemical damage, and liver regeneration as a prime therapy for liver failure and disease. By addressing the urgent need for translating basic research findings into clinically relevant modalities and potential therapeutic applications, the book provides the data needed to improve liver patient management. Hundre
Liver -- Diseases. --- Liver -- Regeneration. --- Stem cells. --- Liver Regeneration --- Computer Simulation --- Stem Cells --- Cells --- Computing Methodologies --- Digestive System Processes --- Regeneration --- Information Science --- Anatomy --- Biological Processes --- Digestive System Physiological Phenomena --- Digestive System and Oral Physiological Phenomena --- Biological Phenomena --- Phenomena and Processes --- Liver --- Regeneration. --- Hepatic regeneration
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Developments in tissue engineered and regenerative medicine products summarizes recent developments in tissue engineering and regenerative medicine with an emphasis on commercialization and product development. Features of current cell therapy and tissue engineered products which have facilitated successful commercialization are emphasized and roadblocks to successful product development are also highlighted. Preclinical and clinical testing of tissue engineered and regenerative medicine products, regulatory, quality control, manufacturing issues, as well as generating and securing intellectua
Liver -- growth & development. --- Liver Regeneration. --- Regenerative Medicine -- methods. --- Stem Cells -- physiology. --- Tissue engineering --- Regenerative medicine --- Culture Techniques --- Medicine --- Health Occupations --- Clinical Laboratory Techniques --- Disciplines and Occupations --- Investigative Techniques --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Regenerative Medicine --- Tissue Engineering --- Health & Biological Sciences --- Biomedical Engineering --- Regenerative medicine. --- Tissue engineering. --- Biomedical engineering --- Tissue culture --- Regeneration (Biology)
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The aim of this Special Issue is to review, understand, and evaluate new and exciting opportunities from the field on regenerative medicine, biomaterials, and stem cell research for the bioengineering of human liver grafts that can be applied for transplantation and personalized treatment of end-stage liver disease.The development of culture conditions for long-term expansion of LGR5+ intestinal stem cells as crypt-villus structures demonstrated the feasibility of deriving complex, organ-like structures in vitro from primary adult tissues, including the liver. Moreover, human pluripotent stem cells (hPSCs) can be applied to generate functionally maturated liver and bile duct epithelial cells.In this Special Issue, we welcome reviews and original papers focussing on hepatic cell sources, including adult hepatic stem cells, organoids, fetal and induced pluripotent stem cells, and primary cells (i.e., hepatocytes, cholangiocytes, and endothelial cells) and how these cells can be applied in tissue engineering strategies to generate implantable and personalized liver grafts. Potential topics include, but are not limited to, the following: liver tissue engineering, liver regeneration, graft repair, liver stem cells and organoids, bio-scaffolds, and 3D printing.We invite you to contribute original research papers, as well as comprehensive reviews, aligned with these themes, to advance and improve the actual state-of-the-art in liver bioengineering and providing new opportunities for the imminent medical problem of organ and tissue shortage for transplantation.
n/a --- tissue engineering --- regenerative medicine --- liver tissue bioengineering --- additive manufacturing --- copper toxicosis --- hepatobiliary stent --- reconditioning --- medical device --- liver regeneration --- Wilson Disease --- stem cells --- preclinical large animal model --- liver --- stem cell transplantation --- liver bioreactors --- personalized medicine --- direct printing --- hydrogel --- 3D structuring --- oxygen persufflation --- end-stage liver diseases --- 3D printing --- liver transplantation --- bioengineered organ --- randomized controlled trail
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Venous Embolization of the Liver: Radiologic and Surgical Practice explores the theoretical advantages and clinical implications for utilizing Venous Embolization techniques, including portal vein and hepatic vein embolization. The practice of venous embolization of the liver was originally developed in Japan by Dr. Makuuchi (one of the co-editors of this book) in 1990 and since then, the techniques reviewed in this book are practiced throughout the world and are now considered the “standard of care” at many hepatobiliary centres worldwide. Venous Embolization of the Liver: Radiologic and Surgical Practice covers a multitude of topics, including: pertinent vascular (microscopic and macroscopic) and surgical anatomy, liver regeneration (including the atrophy-hypertrophy complex), historical perspectives of major hepatic resection, various hepatobiliary surgical procedures , factors affecting hypertrophy, pathophysiology of embolization and resection, embolization techniques (including approaches and embolic agents), the indications for embolization and resection (including pre-operative volumetric and functional assessment and post-embolization followup), potential complications, outcomes data for different diseases, recently advocated strategies (including “definitive” treatment of hepatocellular carcinoma using portal vein embolization after transcatheter arterial chemoembolization) and future perspectives. This book is a valuable resource for interventional radiologists and hepatobiliary surgeons who perform the embolization procedures and liver resections. Venous Embolization of the Liver: Radiologic and Surgical Practice can also be used secondarily by diagnostic radiologists, medical oncologists specializing in gastrointestinal malignancies, hepatologists, gastroenterologists, liver transplant surgeons and basic scientists interested in liver regeneration physiology research.
Liver --- Therapeutic embolization. --- Veins --- Cancer --- Surgery. --- Regeneration. --- Liver -- Cancer -- Surgery. --- Liver -- Regeneration. --- Veins -- Surgery. --- Therapeutic embolization --- Hemostatic Techniques --- Portal System --- Embolization, Therapeutic --- Portal Vein --- Medicine. --- Radiology. --- Interventional radiology. --- Surgical oncology. --- Medicine & Public Health. --- Imaging / Radiology. --- General Surgery. --- Surgical Oncology. --- Interventional Radiology. --- Radiology, Medical. --- Oncologic surgery --- Oncological surgery --- Surgical oncology --- Surgery, Primitive --- Medicine --- Clinical radiology --- Radiology, Medical --- Radiology (Medicine) --- Medical physics --- Radiology, Interventional --- Medical radiology --- Therapeutics --- Excision --- Treatment --- Interventional radiology . --- Radiological physics --- Physics --- Radiation
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The Special issue "Biological and Pharmacological Activity of Plant Natural Compounds II" is continuing the intriguing research on the use of natural plant products. The second edition follows the aim of the first one.
Bergenia species --- botanical description --- traditional uses --- phytochemistry --- pharmacology --- anti-urolithiatic activity --- bergenin --- Flaxseed oil --- linusorb B3 --- anti-cancer --- apoptosis --- actin polymerization --- Src --- glioblastoma --- chlorogenic acid --- coffee --- cyclooxygenase --- espresso --- instant coffee --- platelet aggregation --- Rubia tinctorum L. --- antioxidants --- polyphenols --- ethylene glycol --- urolithiasis --- histophatology --- Saccharomyces cerevisiae --- β-glucan --- antimicrobial and anticancer activities --- detoxification ability --- immunomodulatory effect --- Aquilaria sinensis --- pheophorbide A --- MMP-2 --- MMP-9 --- HT-1080 --- advanced glycation end product (AGE) --- oxidative stress --- epithelial to mesenchymal transition --- AGE-inhibitor --- swertiamarin --- diabetic nephropathy --- astragaloside IV --- Astragalus membranaceus --- huang qi --- Astragali Radix --- liver --- liver regeneration --- 70% partial hepatectomy --- proliferation --- rat --- memory --- object recognition --- Ginkgo biloba --- dorsal hippocampus formation --- brain-derived neurotrophic factor --- Diclofenac --- γ-lactone --- nano-emulsion --- methylcellulose --- Ostrich oil --- Struthio camelus --- Caenorhabditis elegans --- leaf extract --- neuroprotection --- antioxidant activity --- DAF-16 --- Clerodendrum infortunatum --- terpenoids --- phenylpropanoids --- antidiabetic --- breast cancer --- Combretum indicum L. --- antidiabetic activity --- histopathology --- UPLC-QTOF/ESI-MS --- network pharmacology --- Biebersteinia heterostemon --- galegine --- hypotensive --- toxicity --- Sage --- Salvia officinalis --- cytotoxicity --- hepatoprotection --- MDA --- TAOxC --- MCF-7 --- HeLA cells --- HepG-2 cells --- Peganum harmala --- anti-inflammatory activity --- antioxidant --- LC-ESI-MS/MS --- traditional medicine --- rheumatoid arthritis --- rosmanol --- carnosol --- Callicarpa longissima --- TLR4/NF-κB/MAPK --- synergistic effect --- diabetes mellitus --- anti-diabetic drugs --- monoterpenes
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