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Pancreatic cancer is the deadliest of the gastrointestinal tract with 5-year survival rates of less than 5%. Given common asymptomatic early disease course, most patients (50%) present with an already metastatic disease, while only 20% can undergo potentially curative resection. The remaining 30% present with locally advanced disease, defined as extended vascular encasement, where the risk of surgical therapy often outweighs its benefits. Traditional thermal local ablative modalities (RFA, MWA, or cryotherapy) have the disadvantage that they are not applicable in proximity to vital vascular structures, which are abundant in the peripancreatic region. Irreversible electroporation (IRE) is an emerging non-thermal alternative that induces apoptosis of tumor cells by the delivery of short repetitive impulses of high-voltage electric current. Given its mostly non-thermal modality, IRE is not hampered by a heat-sink effect and is applicable with little risk around vascular structures, bile and pancreatic ducts. Recent research suggests that local tumor destruction through IRE improves overall survival, progression-free survival and quality of life in patients with locally advanced pancreatic cancer.
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Pancreas --- Pancreatic Diseases --- Pancreas. --- Diseases --- Diseases. --- Disease, Pancreatic --- Diseases, Pancreatic --- Pancreatic Disease --- Digestive organs --- Endocrine glands --- Exocrine glands
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Pancreas --- Diseases --- Diseases. --- Digestive organs --- Endocrine glands --- Exocrine glands --- Gastroenterology. --- Pancreatic Diseases. --- Disease, Pancreatic --- Diseases, Pancreatic --- Pancreatic Disease --- Hepatology
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'Pancreatology: from Bench to Bedside' focusses on recent advances in pancreatic basic research, genetics of the pancreatic diseases and its surgical management. Basic research discusses the implication of pancreatic stress protein in acute pancreatitis and pancreatic cancer and their possible role as therapeutic targets. Also, very original results show the unexpected role of lipids as mediators during acute pancreatitis. Gene screening strategies allow the detection of the genes responsbile for gemcitabine resistance of pancreatic cancer cells . They lead to the selection of several target genes, in order to suppress the resistance of cells to gemcitabine treatment. The mechanism by which tetrahydrocannabinol is anti-tumoral in pancreatic cancer cells is presented and the use of THC as a promising new therapeutic agent is discussed. Genetic data are shown concerning hundreds of families with hereditary chronic pancreatitis and their possible role in the pathogenesis of the disease. Another very original study addresses the prevention and treatment of pancreatic diseases with diat. In clinical research, convincing data about the use of endoscopic sphicterotomy in the management of acute bilary pancreatitis is presented, based on the experience of a Center highly specialized in pancreatic diseases.
Pancreas -- Diseases. --- Pancreas. --- Pancreatic Diseases -- physiopathology -- Congresses. --- Pancreatic Diseases -- therapy -- Congresses. --- Pancreas --- Pancreatic Diseases --- Congresses --- Digestive System Diseases --- Publication Formats --- Diseases --- Publication Characteristics --- Gastroenterology --- Surgery - General and By Type --- Surgery & Anesthesiology --- Medicine --- Health & Biological Sciences --- Pancreatitis. --- Diseases. --- Inflammation --- Medicine. --- Internal medicine. --- Gastroenterology. --- Hepatology. --- Surgery. --- Surgical oncology. --- Medicine & Public Health. --- Internal Medicine. --- Surgical Oncology. --- Clinical medicine. --- Cancer --- Oncologic surgery --- Oncological surgery --- Surgical oncology --- Medicine, Clinical --- Medicine, Internal --- Internal medicine --- Digestive organs --- Surgery, Primitive --- Excision --- Treatment --- Gastroenterology .
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Liver Diseases --- Pancreatic Diseases --- Biliary Tract Diseases --- Digestive System Surgical Procedures --- Liver --- Pancreas --- Biliary tract --- surgery --- methods --- Surgery. --- Biliary Tract Surgical Procedures --- Surgery
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As a single comprehensive reference source and full-colour atlas, this book covers a wide range of pathology. Normal anatomy as well as developmental abnormalities are detailed. A variety of non-neoplastic conditions are covered, including transplant pathology, diabetes mellitus and pancreatitis. Neoplasms are emphasized. The difficulties encountered with frozen section diagnosis, cytopathology, and tumor classification systems are addressed. Common and rare conditions of pancreas, gallbladder, extrahepatic biliary tract and ampullary regions are all extensively reviewed. Special attention is paid to clinical features, prognostic factors, biologic behavior and survival. With almost 1,300 colour images and over 5,300 references, this treatise is a major contribution to field.
Biliary Tract --- Pancreas --- Pancreatic Neoplasms --- Digestive System Neoplasms --- Endocrine Gland Neoplasms --- Digestive System --- Pancreatic Diseases --- Digestive System Diseases --- Neoplasms by Site --- Endocrine System Diseases --- Anatomy --- Diseases --- Neoplasms
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Frozen Sections are performed while a patient is undergoing surgery as a basis for making an immediate diagnosis that will impact treatment decisions. Frozen section diagnosis is often a highly demanding situation for the pathologist who must render a diagnosis quickly for the patient and surgeon. The Frozen Section Library series will provide concise, user-friendly, site specific handbooks that are well illustrated and highlight the pitfalls, artifacts and differential diagnosis issues that arise in the hurried frozen section scenario.
Frozen tissue sections -- Atlases. --- Pancreas -- Diseases -- Atlases. --- Pancreatic Diseases -- Atlases. --- Pancreatic Diseases. --- Digestive System --- Digestive System Diseases --- Cryoultramicrotomy --- Diseases --- Microtomy --- Anatomy --- Histocytological Preparation Techniques --- Histological Techniques --- Cytological Techniques --- Clinical Laboratory Techniques --- Pancreas --- Frozen Sections --- Pancreatic Diseases --- Investigative Techniques --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Medicine --- Health & Biological Sciences --- Gastroenterology --- Pathology --- Frozen tissue sections --- Frozen histological sections --- Frozen sections (Histology) --- Histological sections, Frozen --- Tissue sections, Frozen --- Medicine. --- Pathology. --- Medicine & Public Health. --- Cryopreservation of organs, tissues, etc. --- Cryotomy --- Tissues --- Digestive organs --- Endocrine glands --- Exocrine glands --- Preservation --- Disease (Pathology) --- Medical sciences --- Medicine, Preventive
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Pancreatic diseases are a crucial issue not only because of their epidemiological significance, and their anatomical and metabolic complexity, but also because of the different treatment options available and their implications for surgery. Due to the slow but steady increase in the incidence of pancreatitis and pancreatic cancer, these diseases are today a real challenge for the surgeon. This volume presents the state of the art of surgery in the treatment of inflammatory and neoplastic pancreatic diseases, describing in detail the different approaches and their most relevant technical aspects. Also described are conventional and interventional radiology, operative endoscopy and endoscopic ultrasonography (which has recently acquired a diagnostic role), and adjuvant and neoadjuvant therapy for treatment or palliation: for only a multidisciplinary approach can produce a global vision, a winning strategy for the optimization of results. Along with the texts, all written by experts, the volume includes color images and drawings. It will prove itself a very useful tool in clinical practice.
Digestive System Diseases --- Diseases --- Pancreatic Diseases --- Surgery & Anesthesiology --- Health & Biological Sciences --- Surgery - General and By Type --- Pancreas --- Digestive organs --- Surgery. --- Medicine. --- Gastroenterology. --- Abdominal surgery. --- Surgical oncology. --- Medicine & Public Health. --- Abdominal Surgery. --- Surgical Oncology.
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Gastroenterology --- Gastroentérologie --- Periodicals. --- Périodiques --- Gastroenterology. --- Gastrointestinal Diseases. --- Functional Gastrointestinal Disorders --- Gastrointestinal Disorders, Functional --- Cholera Infantum --- Disease, Gastrointestinal --- Diseases, Gastrointestinal --- Disorder, Functional Gastrointestinal --- Disorders, Functional Gastrointestinal --- Functional Gastrointestinal Disorder --- Gastrointestinal Disease --- Gastrointestinal Disorder, Functional --- Infantum, Cholera --- Gastroduodenal diseases --- Organ transplantations --- Pancreatic diseases --- Liver diseases --- Gastrointestinal Diseases --- Internal medicine --- Digestive organs --- Diseases --- Human medicine --- Gastrointestinal Disorders --- Gastrointestinal Disorder --- gastroenterology --- gastroduodenal diseases --- organ transplantations --- pancreatic diseases --- liver diseases
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Pancreatic Cytopathology by David C. Chhieng, MD and Edward B. Stelow, MD will fulfill the need for an easy-to-use and authoritative synopsis of pancreas cytopathology. This volume, part of the Essentials in Cytopathology book series, fits into the lab coat pocket and is ideal for portability and quick reference. Each volume in the series is heavily illustrated with a full color art program, while the text follows a user-friendly outline format.
Medicine & Public Health. --- Pathology. --- Medicine. --- Médecine --- Pathologie --- Cytodiagnosis -- Methods. --- Pancreas -- Cytopathology -- Handbooks, manuals, etc. --- Pancreas -- Pathology. --- Pancreatic diseases -- Diagnosis. --- Laboratory Techniques and Procedures --- Digestive System --- Digestive System Diseases --- Pancreas --- Cytodiagnosis --- Pancreatic Diseases --- Anatomy --- Diagnosis --- Diseases --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Medicine --- Pathology --- Gastroenterology --- Health & Biological Sciences --- Diseases. --- Computer security. --- Systems and Data Security. --- Computer privacy --- Computer system security --- Computer systems --- Computers --- Cyber security --- Cybersecurity --- Electronic digital computers --- Protection of computer systems --- Security of computer systems --- Data protection --- Security systems --- Hacking --- Disease (Pathology) --- Medical sciences --- Medicine, Preventive --- Protection --- Security measures
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