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Book
In Memory of Stefan Kunz
Authors: ---
Year: 2022 Publisher: Basel : MDPI - Multidisciplinary Digital Publishing Institute,

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Abstract

This issue of Viruses is a living memorial dedicated to Professor Stefan Kunz, who passed away too early in life, at 54. During his scientific career, Stefan made major contributions to the field of virology. He made seminal contributions to our understanding of how mammarenaviruses gain access to and are trafficked within their target cells. This issue of Viruses contains a collection of articles by leading researchers in different areas of virus-host cell interactions and who crossed pathways with Stefan. The topics covered in the issue include novel insights on mammeranavirus cell entry, host innate and adaptive immune responses to infection, recent developments on therapeutics against human pathogenic arenaviruses, as well as mammarenavirus ecology and molecular pathogenesis. The collection of articles is also a reflection of Stefan's enthusiasm for exploring new ideas and his very collegial attitude reflected by his many collaborations, including the colleagues who have contributed sections to this memorial issue.

Keywords

Life (Biology)


Book
Thermal and Non-Thermal Treatments to Preserve and Encourage Bioactive Compounds in Fruit and Vegetables Based Products
Authors: ---
Year: 2023 Publisher: Basel : MDPI - Multidisciplinary Digital Publishing Institute,

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Fruit- and vegetable-based products (F&Vs) have been conventionally processed using thermal techniques such as pasteurization, scalding, and/and drying, ensuring microbial safety and/or enzyme deactivation. Although thermal treatments are the most cost-effective tools, they could also reduce bioactive compounds, nutrients, and even sensory attributes. Nowadays, non-thermal food-processing technologies such as UV light and high-pressure processing have been proposed to develop food products with extended shelf life and preserved/encouraged bioactive compounds, while preserving the sensory properties. This reprint addresses the existing knowledge gaps of novel thermal and non-thermal techniques in the production of F&Vs and their derivatives. This reprint focuses on the effect of thermal and non-thermal treatments (light stresses, high hydrostatic pressure, pulse electric fields, oscillating magnetic fields, cold plasma, ultrasound, drying, etc.) on shelf-life, key bioactive compound changes (antioxidants, nutraceuticals, flavonoids, and non-flavonoids), enzymatic antioxidant systems, and non-enzymatic antioxidant systems of fruit- and vegetable-based products. Apart from an editorial written by the guest editors, the Special Issue consists of 13 papers that cover a range of subjects: thermal and non-thermal treatments on whole fruits (n = 4); thermal and non-thermal treatments on fruit and vegetable byproducts (n = 3); and, thermal and non-thermal treatments on fruit-based beverages and purées (n = 6).

Keywords

Life (Biology)


Book
Nutritional Management of Cystic Fibrosis
Authors: ---
Year: 2023 Publisher: Basel : MDPI - Multidisciplinary Digital Publishing Institute,

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Abstract

Cystic Fibrosis is an inherited disease that starts in utero. It is caused by a defective protein called the CF transmembrane conductance regulator (CFTR) and while the effects are seen throughout the body, changes in the lungs, gastrointestinal tract, pancreas and liver primarily impact nutritional status. Survival and pulmonary function have been linked to nutritional status. Malnutrition and growth failure were historically the hallmark of disease. Patients with pancreatic insufficiency require pancreatic enzyme replacement therapy and fat-soluble vitamin supplements. With improvements in many areas including newborn screening, nutrition supplements, pancreatic enzymes, CFTR modulator drugs, inhaled antibiotics and mucolytics, life expectancy has increased. In this issue, we will review the latest information in children and adults regarding important factors that play a role in optimizing nutrition status, including body composition, the gut microbiome, food security, pancreatic enzyme replacement therapy, growth and bone health, and micronutrient abnormalities. Pediatric and adult providers both need to be aware of the nuances of care as more patients with CF become adults. Optimizing nutritional status, anticipating and preventing the complications of CF will result in best management practice.

Keywords

Life (Biology)


Book
Purinergic Signaling in Neuroinflammation
Authors: ---
Year: 2023 Publisher: Basel : MDPI - Multidisciplinary Digital Publishing Institute,

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Abstract

It is currently apparent that extracellular ATP's physiological effect is mediated by its interaction with specific purinergic receptors. All purinergic receptors are divided into P1-purinoreceptors and P2-purinoreceptors. Each of the subtypes is divided into a number of families. For instance, P2 receptors are divided into P2X and P2Y receptors according to the mechanism by which their effect is realized: P2Y are G-protein-coupled receptors, while P2X receptors are ligand-operated ion channels. P2X receptors are important molecular therapeutic targets, the malfunctioning of which leads to severe complications in the physiology of humans and animals and causes dangerous diseases. The search for compounds that can modulate the function of purinergic receptors can lead to the creation of new drugs that are effective in central and peripheral nervous system and immune system disease treatment, including neuroinflammation, hypoxia/ischemia, epilepsy and neuropathic pain. In this Special Issue, we wish to offer a platform for high-quality publications on the latest advances in the identification of P2X/Y- and P1-receptor blockers, functions and regulation by them; the characterization of these receptor signaling networks and crosstalk; mechanisms underlying the role of purinoceptors in neurodegenerative illnesses as well as chronic neuronal changes following acute noxious damage and therapeutic opportunities associated with regulation of purinergic receptor activity.

Keywords

Life (Biology)


Book
Nuts : Where We Are and Where We Are Going in Research. Proceedings from the NUTS 2022 International Conference
Authors: --- ---
Year: 2023 Publisher: [Place of publication not identified] : MDPI - Multidisciplinary Digital Publishing Institute,

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Humans have eaten nuts for thousands of years, yet their consumption was discouraged just a few decades ago due to their high-fat content. This perspective began to change in the early 1990s due to seminal publications from the Adventist Health Study, which showed that nut consumption significantly improved heart health-related outcomes. Many randomized clinical trials, epidemiological studies, and in vitro/in vivo mechanistic studies have since explored the role of eating nuts and its relation to health. Similarly, dried fruits have been scrutinized due to their concentrated sugar content despite their non-sodium micronutrient and fiber density. Due to accumulating evidence on nut and dried fruit intake and health outcomes, an international scientific meeting was organized for leading experts to examine and recapitulate in detail what is well known and established and what avenues of knowledge are still lacking in nut and dried fruit research. This book summarizes proceedings from this international scientific meeting and the latest information relating to: (1) energy balance and body weight; (2) insulin resistance and diabetes; (3) lipoproteins and dyslipidemia; (4) gastrointestinal system; (5) inflammation and oxidation; (6) cardiovascular disease; (7) cognition; (8) cancer; (9) dried fruit and health; (10) future lines of research. These findings highlight the beneficial health potentials of nuts for researchers, health professionals, other stakeholders, and the public while simultaneously pinpointing areas for further investigation to continue informing and guiding health practices and policies.


Book
Life and technology : an inquiry into and beyond Simondon
Authors: ---
Year: 2015 Publisher: Luneburg : Meson Press,

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Annotation The philosophy of Gilbert Simondon has reinvigorated contemporary thinking about biological and technological beings. In this book, Jean-Hugues Barthelemy takes up Simondon's thought and shows how life and technology are connected by a transversal theme: individuation. In the first essay, Barthelemy delivers a contemporary interpretation of Simondon's concept of ontogenesis against the backdrop of biology and cybernetics. In the second essay, he extends his reflections to propose a non-anthropological understanding of technology, and so sets up a confrontation with the work of Martin Heidegger."


Book
Cells, Cells and Nothing but Cells : Discoveries, Challenges and Directions
Author:
Year: 2023 Publisher: [Place of publication not identified] : MDPI - Multidisciplinary Digital Publishing Institute,

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The forum is for scientists doing research in different fields of cell science including, but not limited to, stem cells, autophagy, aging, intracellular organelles, proteomics, genomics, metabolism, and cell physiology. The goal of the symposium was to bring scientists together to facilitate the exchange of data and novel ideas to advance cell science as well as discussing the challenges facing cell biologists.


Book
Biology
Authors: --- --- ---
ISBN: 1947172514 9781947172517 Year: 2018 Publisher: OpenStax

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Abstract

Biology 2e is designed to cover the scope and sequence requirements of a typical two-semester biology course for science majors. The text provides comprehensive coverage of foundational research and core biology concepts through an evolutionary lens. Biology includes rich features that engage students in scientific inquiry, highlight careers in the biological sciences, and offer everyday applications. The book also includes various types of practice and homework questions that help students understand—and apply—key concepts. The 2nd edition has been revised to incorporate clearer, more current, and more dynamic explanations, while maintaining the same organization as the first edition. Art and illustrations have been substantially improved, and the textbook features additional assessments and related resources.


Book
Polylactide-Based Materials : Synthesis and Biomedical Applications
Authors: ---
ISBN: 3036566414 3036561269 Year: 2023 Publisher: Basel : MDPI - Multidisciplinary Digital Publishing Institute,

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This reprint focuses on PLA-based materials and the modification of their properties for biomedical applications. Special emphasis is placed on the supramolecular strategies that lead to unique structures in the micro- or nanoscale. The development and testing of novel biomaterials as drug delivery carriers, implants, or tissue engineering scaffolds are of particular interest. Special attention is given to understanding the structure-properties relationship, since this allows for the development of the most effective biocompatible materials.


Book
The Biological and Clinical Aspects of Merkel Cell Carcinoma
Authors: --- ---
Year: 2023 Publisher: [Place of publication not identified] : MDPI - Multidisciplinary Digital Publishing Institute,

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