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Efforts to miniaturize sensing and diagnostic devices and to integrate multiple functions into one device have caused massive growth in the field of microfluidics and this integration is now recognized as an important feature of most new diagnostic approaches. These approaches have and continue to change the field of biosensing and diagnostics. In this Special Issue, we present a small collection of works describing microfluidics with applications in biosensing and diagnostics.

therapeutic drug monitoring (TDM) --- aminoglycosides --- size and mobility traps (SMT) --- microfluidics --- numerical techniques --- Microsoft Excel --- finite difference method --- Navier–Stokes --- time dependent flow --- dynamic flow --- initiation of flow --- Poiseuille flow --- point-of-care --- biosensor --- hybrid integration --- acoustofluidics --- cavitation --- micromixing --- optical absorbance --- colorimetry --- salivary potassium --- biomolecules --- microfluidic --- dielectrophoretic immobilization --- CMOS biosensor --- lab-on-chip --- microfluidic probe --- droplet --- sampling --- Taylor dispersion --- diagnostic --- GMR sensor --- whole cell --- microdroplets --- photo-isomerisation --- photokinetics --- opto-mechanics --- conformational states

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Building on advances in miniaturization and soft matter, surface tension effects are a major key to the development of soft/fluidic microrobotics. Benefiting from scaling laws, surface tension and capillary effects can enable sensing, actuation, adhesion, confinement, compliance, and other structural and functional properties necessary in micro- and nanosystems. Various applications are under development: microfluidic and lab-on-chip devices, soft gripping and manipulation of particles, colloidal and interfacial assemblies, fluidic/droplet mechatronics. The capillary action is ubiquitous in drops, bubbles and menisci, opening a broad spectrum of technological solutions and scientific investigations. Identified grand challenges to the establishment of fluidic microrobotics include mastering the dynamics of capillary effects, controlling the hysteresis arising from wetting and evaporation, improving the dispensing and handling of tiny droplets, and developing a mechatronic approach for the control and programming of surface tension effects. In this Special Issue of Micromachines, we invite contributions covering all aspects of microscale engineering relying on surface tension. Particularly, we welcome contributions on fundamentals or applications related to:Drop-botics: fluidic or surface tension-based micro/nanorobotics: capillary manipulation, gripping, and actuation, sensing, folding, propulsion and bio-inspired solutions; Control of surface tension effects: surface tension gradients, active surfactants, thermocapillarity, electrowetting, elastocapillarity; Handling of droplets, bubbles and liquid bridges: dispensing, confinement, displacement, stretching, rupture, evaporation; Capillary forces: modelling, measurement, simulation; Interfacial engineering: smart liquids, surface treatments; Interfacial fluidic and capillary assembly of colloids and devices; Biological applications of surface tension, including lab-on-chip and organ-on-chip systems. We expect novel as well as review contributions on all aspects of surface tension-based micro/nanoengineering. In line with Micromachines' policy, we also invite research proposals that introduce ideas for new applications, devices, or technologies.

electrodynamic screen --- soft tissue --- microstructure --- mist capillary self-alignment --- droplet --- lab-on-a-chip --- mixing --- nanoprecipitation --- asymmetric surfaces --- gecko setae --- oil-water interface --- non-invasive control --- self-cleaning surface --- corrosive resistance --- micropipette-technique --- hydrophobic --- wettability gradient --- lung-surfactants --- hydrophilic --- dynamic --- vibrations --- superhydrophobic --- microasssembly --- adsorption --- wetting --- photochemical reaction --- contact line oscillation --- 355 nm UV laser --- capillary --- computational fluid dynamics --- bearing --- solutal Marangoni effect --- relaxation oscillations --- superhydrophilic --- microtexture melting --- rigid gas permeable contact lenses --- hydrophilic/superhydrophobic patterned surfaces --- polydimethylsiloxane (PDMS) replication --- microfabrication --- actuation --- droplet transport --- “droplet-interface-bilayers” --- microfluidics --- electrosurgical scalpels --- continuous-flow reactor --- air-water surface --- micromanufacturing --- surface treatment --- liquid bridge --- stereolithography --- super-hydrophobic --- two-phase flow --- hot drop --- durable --- insoluble lipids --- anti-sticking --- smart superhydrophobic surface --- droplet manipulation --- “black lipid films” --- condensation --- pick-and-place --- wettability --- gas-microbubbles --- soft robotics --- capillary pressure --- superomniphobic --- self-lubricating slippery surface --- electrowetting --- soluble surfactant --- anisotropic ratchet conveyor --- Nasturtium leaf --- droplets --- photoresponsible surfactant --- two-photon polymerization --- contact angle --- adhesion --- transport --- pick and place --- surface tension --- oil-microdroplets --- micromanipulation --- laser die transfer --- capillary gripper --- equilibrium