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Numerous pathogens affect animal health and wellbeing and production efficiency. These pathogens also have a considerable impact on social economics, food safety and security, and human health. Infectious diseases that originate from both domesticated animals and wildlife represent one of the greatest threats to human health. Recent studies show that domesticated species harbor approximately 84 times more zoonotic viruses than wild species. Eight of the top 10 mammalian species with the highest number of zoonotic viruses are domestic, such as pigs, cattle, and horses. Many animal parasites are also zoonotic, constituting an additional burden on human health. Furthermore, the rapid emergence and spread of drug-resistant pathogen strains pose new threats to animal and human health. Climate changes will undoubtedly alter the interactions between animals and between animals and humans, which will have a huge impact on the transmission rate of existing pathogens and the emergence of new pathogens or the reemergence of old pathogens. In this special collection, interactions of all major pathogen types, including viruses, bacteria, mites and flies, protozoans, and helminths, and their hosts, such as wild and companion animals and livestock species, are discussed. Further, anthelmintic activities of natural products are evaluated. The relevance and utility of cutting-edge tools, such as immunology, genomics and genetics, microbiome studies and metabolomics, and molecular epidemiology, in dissecting host-pathogen interactions are also discussed. This special collection provides a broad knowledge base that encourages dialogue across a wide distribution of the research community in veterinary microbiology and parasitology.

dietary treatments --- plant bioactive compounds --- egg counts --- UHRMS --- Haemonchus contortus --- Crotalus ravus --- Crotalus triseriatus --- venom --- antibacterial activity --- Pseudomonas aeruginosa --- hemolytic activity --- maedi-visna virus --- ovine progressive pneumonia --- small ruminant lentivirus --- dairy sheep --- horse --- colic --- gastrointestinal disease --- Strongylus vulgaris --- Anoplocephala perfoliata --- cyathostominae --- D. gallinae --- hematophagous ectoparasite --- poultry red mite --- antibody titre --- lymphocyte subpopulation --- Sarcocystis spp. --- COX1 --- Camelus dromedarius --- post-mortem microbiology --- veterinary forensic pathology --- sudden death --- young dogs --- bovine digital dermatitis --- cattle lameness --- microbiome --- Treponema spp --- Ancylostoma ceylanicum --- community dogs --- ITS region --- cox1 --- Thailand --- population diversity --- Sarcoptes scabiei --- host-parasite interaction --- molecular characterization --- lipid profile --- antioxidant --- rodent --- helminth --- cestode --- trematode --- nematode --- Middle East --- meta-analysis --- Brugia pahangi --- Dirofilaria immitis --- PCR-RFLP --- spatial distribution --- altitude --- myiasis --- prevalence --- Oestrus ovis --- mtCOI --- sheep --- goats --- Saudi Arabia --- anoplocephala perfoliata --- equine --- gut microbiome --- volatile organic compounds (VOCs) --- omics integration --- tick-borne fever --- Anaplasma phagocytophilum-like 1 --- small ruminant

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Lignans are a class of natural products found mainly in plants. They have a wide variety of structures and exhibit a range of potent biological activities. Lignans are also well-known components of a number of widely eaten foods and are frequently studied for their dietary impact. Owing to these factors, lignans have been extensively studied by scientists from a large number of disciplines. This collection of research and review articles describes topics ranging in scope from the recent isolation and structural elucidation of new lignans, strategies towards the chemical synthesis of lignans, assessment of their biological activities and potential for further therapeutic development. Research showing the impact of lignans in the food and agricultural industries is also presented.

taste-active compound --- heilaohu --- 9-norlignans --- antioxidant activity --- drug-like --- human health --- chemometrics --- lignan --- bitterness --- red-flowered Chinese magnolia vine --- antioxidant --- ruminant --- secoisolariciresinol diglucoside --- quantification --- intermolecular interactions --- cattle --- anti-inflammatory activity --- acyl-Claisen --- LOX --- seed --- food groups --- microtubules --- anti-proliferative --- acetylcholinesterase inhibitors --- flax --- arylnaphthalene lignan --- epiboly --- aryldihydronaphthalene lignan --- multiple bioactive components --- enterolignan --- total synthesis --- genetic --- synthesis --- cultivated --- cell cycle --- chronic diseases --- national databases --- oxidation --- chemical components --- molecular dynamics --- COX --- lignans --- hydroxycinnamic acid --- chemical structures --- Chinese magnolia vine --- stereoselective synthesis --- sPLA2 --- Bursera fagaroides --- in silico studies --- antibacterial activity --- semisynthesis --- dibenzyl butyrolactones --- flavonoid glycoside --- lignan glycoside --- chemical characterization --- hydroxymatairesinol --- podophyllotoxin --- Lespedeza cuneata --- Bursera --- oak ageing --- Schisandrae Chinensis Fructus --- F-actin --- cultivar --- UHPLC-MS/MS --- bioactivity --- podophyllotoxin-type lignans --- harmonized databases --- graph theory --- antioxidants --- health promotion --- simultaneous quantitation --- natural products --- dietary intake --- cell migration --- Lignan --- chemical space --- diet --- Lauraceae --- pharmacokinetic --- cytotoxicity --- tujia ethnomedicine --- flavonolignans --- flavonol --- adipocyte and osteoblast differentiation --- Burseraceae --- environment --- dietary lignans --- phytochemical analysis --- Schisandra chinensis --- animal health --- neolignans --- Schisandra rubriflora --- cancer --- norlignans --- wild

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The pestiviruses encompass some of the most economically important viral infections in the cattle, swine, and sheep industries worldwide. Discovered more than 70 years ago, bovine viral diarrhea virus (BVDV) and classical swine fever virus (CSFV) were long the main concern, but many new pestiviruses have emerged in recent years, which may also present additional threats to biosecurity and food safety. This issue brings together contributions from multiple disciplines – virology, immunology, veterinary clinical medicine, epidemiology, and pathology – on the subject of BVDV and related pestiviruses, and cover host–virus interactions, virus–cell interactions, cross-species transmission as well as the role of wildlife species as reservoirs of some of the pestiviruses.

Linda virus --- serological profile --- virus neutralization assay --- virus pathogenicity --- humoral immune response --- pestivirus --- pig --- APPV --- phylogenetic analysis --- Italy --- bvdv --- epidemiology --- reindeer --- border disease virus --- Norway --- Pestivirus --- BVDV --- CD46 --- life cell imaging --- attachment --- surface transport --- experimental infection --- natural infection --- pigs --- bovine viral diarrhoea virus --- persistent testicular infection --- prolonged testicular infection --- bovine --- testes --- semen --- wild boar --- ML tree --- Clade --- Bungowannah virus --- pestivirus F --- ruminant infection --- foetus --- porcine --- real-time PCR --- serology --- virology --- bovine viral diarrhea virus --- cytopathic BVDV --- immunosuppression --- lymphocyte apoptosis --- monocyte-derived macrophages --- non-cytopathic BVDV --- Australia --- deer --- prevalence --- ruminants --- serosurveillance --- wildlife disease --- diarrhea --- bovine respiratory disease --- milk production --- somatic cells count (SCC) --- reproductive performance --- BVDV persistent infection --- fetus --- thymus --- immune response --- flavivirus --- reverse genetics --- single round infectious particle --- bovine viral diarrhea virus (BVDV) --- escape mutant --- ERNS --- adaptation --- CRISPR --- knockout --- MDBK --- cell entry --- pestiviruses --- congenital tremor type A-II --- persistent infection --- rangeland beef herds --- northern Australia --- atypical porcine pestivirus (APPV) --- viral persistence --- congenital tremor --- swine --- asymptomatic --- genomic sequence --- purifying selection --- bovine pestiviruses --- bovine viral diarrhoea --- vaccination --- control --- diagnosis --- antigenic cross-reactivity --- n/a