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This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact

spermatogenesis --- sperm --- capacitation --- manchette --- centriole --- cilia --- contraceptive pill --- piRNA

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Azoospermia, defined as the absence of sperm in the ejaculate after examination of the centrifuged specimens, affects about 1% of the male population and 10–15% of infertile men. In about two-thirds of cases, this is caused by severe spermatogenic dysfunction, and it is commonly termed “nonobstructive azoospermia” (NOA) to differentiate it from the less severe form of azoospermia caused by the obstruction of the seminal tract (obstructive azoospermia—OA), the latter affecting the remaining one-third of cases. Managing patients with NOA is challenging due to the severity of spermatogenic dysfunction and the lack of medical treatments, with surgical retrieval of testicular sperm being the only way of enabling some of these patients to father their own biological children. In-depth clinical knowledge is key for supporting clinical reasoning and decision making when counselling patients with NOA, and surgical skill is required to maximize the outcome of surgical procedures that aim to retrieve testicular sperm. The present book is a collection of scientific papers published in a Special Issue of the Journal of Clinical Medicine, authored by some of the most influential researchers in the field. The Special Issue, and thus also this book, were conceived to provide early career reproductive urologists and endocrinologists with an update of the scientific evidence in the field, together with surgical tips.

nonobstructive azoospermia --- micro-TESE --- FSH treatment --- hormonal treatment --- testosterone level --- microdissection testicular sperm extraction --- non-obstructive azoospermia --- management --- infertility --- intracytoplasmic sperm injection --- testicular azoospermia --- sperm selection --- sperm --- cryopreservation --- in vitro maturation --- azoospermia --- diagnosis --- male infertility --- spermatogenic failure --- testis biopsy --- sperm retrieval --- genetic testing --- endocrine evaluation --- review --- hypogonadism --- Sertoli cell-only syndrome --- testicular spermatozoa --- processing --- microfluidics --- new technologies --- genetics --- exome --- WES --- Y chromosome --- cancer --- NOA --- genes --- general health --- ICSI --- offspring health --- microTESE --- prediction model --- n/a

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While it has been argued that anonymity in gamete donation has been brought to an end by legal changes and technological developments, Amelie Baumann suggests that this is in fact still in transformation. By focusing on the narratives of those who were conceived with anonymously donated gametes in Germany and the UK, she examines this transformative process and the role which donor-conceived persons play in it. This book shows that it is not someone's decision to procreate that turns »being donor-conceived« into a meaningful categorisation. Rather, kinship knowledge gets activated by the donor-conceived in specific ways for »being donor-conceived« to become a powerful identification.

Birthparents --- Law and legislation. --- Anonymity Kinship. --- Cultural Anthropology. --- Donor Conception. --- Family. --- Law. --- Medical Ethics. --- Medicine. --- Sociology of Family. --- Sociology of Medicine. --- Sperm Donation.

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This book presents the latest advances in assisted reproductive technologies applied to ruminants, such as multiovulation, artificial insemination, embryo transfer, and in vitro fertilization (IVF), which have been useful tools to accelerate the genetic progress in these species. The reader will find detailed studies on bisons, bovines, and goats

sperm viability --- embryo production --- fertilization --- blastocyst --- caprine --- COC --- IVF --- IVP --- IVEP --- oocyte competence --- photoperiod --- reproductive efficiency --- season --- seasonal breeder --- HSP70 --- heat stress --- in vitro embryos --- gene expression --- cattle --- Holstein --- Mediterranean Water Buffalo --- in vitro embryo production --- laparoscopic ovum pickup --- accelerated genetic gain --- prepubertal --- embryo development --- wisent --- European bison --- oocytes --- sperm --- embryos --- embryo transfer --- germplasm bank --- threatened species

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Spermatogenesis requires radical restructuring of germline chromatin at multiple stages, involving coordinated waves of DNA methylation/demethylation, histone modification, and the replacement and removal that occurs before, during, and after meiosis. This Special Issue will draw together papers that address all aspects of chromatin organization and dynamics in the male germ line, in humans, and in model organisms. In particular, we will invite authors to discuss novel methods for studying germline chromatin structure, the interplay between chromatin structure and susceptibility to DNA damage and mutation, chromatin modifications associated with epigenetic inheritance in the early embryo, and the impact this work has for understanding natural fertility and improving assisted reproduction techniques.

mouse sperm chromatin --- chromosome organization --- nuclear-3D-parameters --- spermiogenesis --- chromatin remodeling --- DNA double-strand breaks --- genetic instability --- mutations --- sperm DNA damage --- DNA fragmentation --- infertility --- assisted reproduction --- miscarriage --- implantation --- nuclear organization --- sperm --- morphometrics --- chromosome painting --- nucleoli --- NOR --- chromosome associations --- meiotic prophase --- spermatocytes --- Mus m. domesticus --- Robertsonian chromosomes --- chromosome translocation --- Y chromosome --- testis --- spermatogenesis --- SLY --- mouse --- oxidative stress --- reactive oxygen species --- chromatin --- DNA oxidation --- male infertility --- spermatozoa --- chromosomes --- chromosome territories --- centromeres --- male germ cells --- telomeres --- reproductive aging --- nuclear organisation --- epigenetic inheritance --- histone retention --- in vitro fertilisation