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Organoids are three-dimensional miniature tissue mimics established from embryonic stem cells, human pluripotent stem cells, adult stem cells, and cancer cells. These fascinating 3D organoids serve as a valuable tool for fundamental research, disease modeling, drug screening and discovery, regenerative medicine, and deciphering the mechanism of disease pathogenesis. This book emphasizes the emerging data and critical resources covering the fundamentals of organoids and their use in modeling and application in various diseases, especially cancer. The chapters deal with organoid bioengineering in cerebral organoids, retinal organoids, tumoroids, and organoid commercialization. This book is intended for a broad readership and is an indispensable resource for basic biologists, translational scientists, and clinicians.

Tissue engineering.

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Biomechanics and Functional Tissue Engineering is a useful resource for scientists, researchers, engineers, and clinical practitioners involved in bioengineering solutions for improved patient quality of life. It focuses on the potentially impactful role of applied and functional bio-dental tissue engineering, drug/gene delivery (controlled and metered systems) and cell therapy, bioscaffolds, image-guided and image-assisted surgery, nanodentistry, and biomechanics towards developing better solutions for problems and conditions of the orodental and cranio-maxillofacial complex and beyond.

Tissues --- Tissue engineering. --- Mechanical properties.

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Tissue Engineering may offer new treatment alternatives for organ replacement or repair deteriorated organs. Among the clinical applications of Tissue Engineering are the production of artificial skin for burn patients, tissue engineered trachea, cartilage for knee-replacement procedures, urinary bladder replacement, urethra substitutes and cellular therapies for the treatment of urinary incontinence. The Tissue Engineering approach has major advantages over traditional organ transplantation and circumvents the problem of organ shortage. Tissues reconstructed from readily available biopsy material induce only minimal or no immunogenicity when reimplanted in the patient. This book is aimed at anyone interested in the application of Tissue Engineering in different organ systems. It offers insights into a wide variety of strategies applying the principles of Tissue Engineering to tissue and organ regeneration.

Tissue engineering. --- Biomedical engineering --- Regenerative medicine --- Tissue culture

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This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact

Tissue engineering --- biofabrication --- delivery vehicles --- in vitro models --- organogenesis

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This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact

hydrogel --- tissue engineering --- regeneration medicine --- stimuli responsive --- high performance