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Hysterectomy is a very common type of surgery and can be a life-saving operation for some women with certain types of cancer or torrential uterine haemorrhage. It can also improve the quality of life for women who experience menometrorrhagia, uterine leiomyomata, endometriosis or uterine prolapse. However, before embarking on hysterectomy, it is important to be aware of and understand all the options available, medical or conservative surgical, as well as their risks and benefits. The most determinant factors for choosing one or another approach are uterine size, organ mobility, parity and previous pathology, in integration with best research evidence, clinical expertise and patient values and expectations. This book is intended for all specialties involved in health care for women.

Hysterectomy. --- Abdominal hysterectomy --- Uterus --- Sterilization of women --- Excision --- Surgery --- Urology & urogenital medicine

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This new approach to the history of motherhood examines the role the female body played in defining motherhood from the mid-eighteenth century through the first half of the nineteenth century, demonstrating that physical representations or perceptions of the body were crucial to defining motherhood in different ways both for mothers themselves and for American culture at large.

Human body --- Women --- Motherhood --- Social aspects --- History. --- Maternity --- Mothers --- Parenthood --- History --- Breastfeeding --- Cess --- Childbirth --- Middle class --- Nursing --- Pregnancy --- Print culture --- Slavery --- Uterus --- Wet nurse

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Effective treatment of postpartum haemorrhage (PPH) often requires simultaneous multidisciplinary interventions. The health care provider needs to begin resuscitative efforts quickly, establish the cause of the haemorrhage, and possibly obtain the assistance of other care providers, such as an obstetrician, anaesthetist or radiologist. Avoiding delays in diagnosis and treatment will have significant impact on sequelae and chance of survival.These guidelines therefore include care pathways for the management of PPH, as a practical guide for clinicians. A loose-leaf insert of these care pathways

Labor (Obstetrics) -- Complications. --- Placenta -- Diseases -- Treatment -- Standards. --- Placenta, Retained -- Practice Guidelines. --- Postpartum Hemorrhage -- Practice Guidelines. --- Puerperal disorders -- Treatment -- Standards. --- Uterine hemorrhage -- Treatment -- Standards. --- Uterus -- Contraction -- Treatment -- Standards. --- Uterine hemorrhage --- Postpartum Hemorrhage --- Practice Guideline --- Placenta, Retained --- Obstetric Labor Complications --- Guideline --- Puerperal Disorders --- Uterine Hemorrhage --- Placenta Diseases --- Pregnancy Complications --- Publication Formats --- Hemorrhage --- Female Urogenital Diseases and Pregnancy Complications --- Publication Characteristics --- Pathologic Processes --- Pathological Conditions, Signs and Symptoms --- Diseases --- Gynecology & Obstetrics --- Medicine --- Health & Biological Sciences --- Treatment --- Standards --- Labor (Obstetrics) --- Placenta --- Uterine hemorrhage. --- Maternity nursing --- Complications. --- Diseases. --- Hemorrhage, Uterine --- Uterus --- Complicated labor (Obstetrics) --- Labor, Complicated --- Labor complications (Obstetrics) --- Pregnancy --- Obstetrical emergencies --- Complications

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The science of human genetics has advanced at an exponential pace since the double-helix structure of DNA was identified in 1953. Within only 25 years of that discovery, the first gene was sequenced. Subsequent efforts in the span of a few decades have brought advanced next-generation sequencing and new tools for genome editing, allowing scientists to write and rewrite the code of life. We are now realizing that genetics represents yet another system of information technology that follows Moore’s law, stating that computer processing power roughly doubles every two years. Importantly, with such rapid and sophisticated advancements, any tools or studies applicable to adult genetics can now also be applied to embryos.Genetic disorders affect 1% of live births and are responsible for 20% of pediatric hospitalizations and 20% of infant mortality. Many disorders are caused by recessive or X-linked genetic mutations carried by 85% of humans. Because assisted reproduction has armed us with technologies like in vitro fertilization that provide access to human embryos, we began to screen some genetic diseases simply by selecting sex. The first live births following preimplantation genetic testing (PGT) to identify sex in X-linked disease were reported by Alan Handyside in 1990. This groundbreaking work used the identification of male embryos and selective transfer of unaffected normal or carrier females as proof-of-concept to avoid genetic diseases, paving the way to extend the concept to PGT for monogenic diseases (PGT-M), including Mendelian single-gene defects (autosomal dominant/recessive, X-linked dominant/recessive), severe childhood lethality or early-onset disease, cancer predisposition, and HLA typing for histocompatible cord-blood stem cells’ transplantation. Later, we moved onto the identification and selection of euploid embryos by analysing all 23 pairs of chromosomes in 4–8 cells from the trophectoderm, called PGT for aneuploidy (PGT-A). PGT-A currently leverages next-generation sequencing technologies to uncover meiotic- and mitotic-origin aneuploidies affecting whole chromosomes, as well as duplications/deletions of small chromosome regions. A step forward was the use of structural chromosome rearrangements (PGT-SR) to identify Robertsonian and reciprocal translocations, inversions, and balanced vs. unbalanced rearrangements. Another advancement came with PGT for polygenic risk scoring (PGT-P). This technique takes us from learning how to read simple words to starting to understand poetry (i.e., evolving from PGT-M/A/SR to PGT-P for multifactorial, polygenic risk prediction). Moreover, we are moving from embryo selection to intervention because the genetic code is not only readable, but also re-writeable. Indeed, gene editing is now possible using tools like CRISPR/Cas9, which are applicable to all species, including human embryos.

extracellular vesicles --- exosomes --- microvesicles --- apoptotic bodies --- DNA --- preimplantation embryos --- murine blastocysts --- embryo --- uterus --- window of implantation --- PGT-A --- PGT-SR --- mosaicism --- embryo genetics --- chromosomal abnormality --- preimplantation genetic testing --- PGT-P --- polygenic risk scoring --- genomic index --- relative risk reduction --- combined preimplantation genetic testing --- Preimplantation genetic testing for monogenic disorders (PGT-M) --- Preimplantation genetic testing for aneuploidy assessment (PGT-A) --- Autosomal dominant polycystic kidney disease (ADPKD) --- male infertility --- advanced maternal age --- aneuploidy --- NGS --- segmental --- translocations --- monogenic disease --- multiplex PCR --- SNP array --- genome editing --- genetic diseases --- embryos --- vitrification --- ovarian response --- female age --- genetic testing --- reproductive health --- next-generation sequencing --- whole exome sequencing --- perinatal care --- infertility --- aneuploidies --- polygenic disease --- blastocyst --- endometrium --- implantation

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Eén op de zes koppels heeft medische hulp nodig om zwanger te raken. Gelukkig voor hen maakte de wetenschap al grote sprongen: van IVF, zaad- en eiceldonatie en draagmoederschap tot baarmoedertransplantatie. Maar daar stopt het niet. Straks kweken we misschien zaad- en eicellen uit onze eigen huid. De vruchtbaarheidsrevolutie komt eraan. De Maakbare Baby is een boek op het kruispunt tussen wetenschap, ethiek en de diepmenselijke kinderwens. De auteurs geven een overzicht van alle mogelijke behandelingen, doorspekt met verhalen van jonge (wens)ouders. Internationaal bekende wetenschappers en filosofen wakkeren mee het maatschappelijke debat aan. Want de vraag blijft: hoe ver gaan we om onze kinderwens te vervullen?

Vruchtbaarheidsproblemen. --- ethiek --- vruchtbaarheidsbehandelingen --- IVF (in vitrofertilisatie) --- draagmoederschap --- kinderrechten --- gezinssociologie --- KI (kunstmatige intelligentie) --- fertiliteit --- kinderwens --- Family law. Inheritance law --- gentherapie --- Sociology of the family. Sociology of sexuality --- Belgium --- Kinderwens --- Vruchtbaarheidsproblemen --- Medische ethiek --- BPB1711 --- 664.1 Gezin --- Droit de la famille --- Procréation artificielle --- Bioéthique --- Mère porteuse --- Droits de l'enfant --- IVF --- donatie --- vruchtbaarheid --- 614.1 --- seksualiteit --- Familierecht --- Kunstmatige voortplanting --- Bio-ethiek --- Draagmoeder --- Rechten van het kind --- Medical ethics --- Human reproductive technology --- Children's rights --- Sociologie van het gezin. Sociologie van de seksualiteit --- Familierecht. Erfrecht --- België --- PXL-Healthcare 2018 --- gynaecologie --- ethische aspecten --- Fertiliteit --- Spermatozoa --- Draagmoederschap --- Baarmoedertransplantatie --- Nieuwsamengestelde gezinnen --- Eiceldonatie --- Embryoselectie --- Genetische manipulatie --- Intra Cytoplasmatische Sperma Injectie --- Getuigenissen --- In-vitrofertilisatie --- drepturile copilului --- otrokove pravice --- Rechte des Kindes --- dječja prava --- vaikų teisės --- barns rättigheter --- права на децата --- права деце --- práva detí --- bērnu tiesības --- diritti del bambino --- cearta an linbh --- të drejtat e fëmijëve --- børns rettigheder --- gyermek jogai --- lapsen oikeudet --- rechten van het kind --- children's rights --- права на детето --- laste õigused --- δικαιώματα του παιδιού --- prawa dziecka --- drittijiet ta-tfal --- direitos da criança --- práva dítěte --- derechos del niño --- Прва детска амбасада во светот --- prava djeteta --- Конвенција за правата на детето --- derechos de la infancia --- derechos del menor --- gyermekeket megillető jogok --- zamjenska majka --- surrogatmamma --- Leihmutter --- dajkaanya --- наета майка --- máthair ionaid --- augļa iznēsātāja --- сурогат мајка --- matka nosicielka --- mãe portadora --- nënë mbajtëse --- mamă purtătoare --- surogatinė motina --- omm surrogata --- φέρουσα μητέρα --- náhradná matka --- rugemor --- surrogate mother --- draagmoeder --- sijaissynnyttäjä --- nadomestna mati --- madre portatrice --- asendusema --- madre portadora --- náhradní matka --- prêt d'utérus --- leenmoeder --- utero in affitto --- béranyaság --- išnešiojusioji motina --- surrogatmoder --- dajkaterhesség --- majka surogat --- madre sostituta --- maternidad subrogada --- madre de alquiler --- surrogatmor --- skolintoji motina --- pótanyaság --- κυοφορούσα για λογαριασμό τρίτων --- mère de substitution --- сурогат мајчинство --- mãe de aluguer --- matka nosička --- sijaisäiti --- béranya --- půjčení dělohy --- δανείζουσα μητέρα --- utero in prestito --- βιοηθική --- bijoetika --- bioética --- bioetica --- bioētika --- bio-ethics --- bioeetika --- биоетика --- bioetyka --- bioetiikka --- bio-ethiek --- bioetică --- bioetik --- Bioethik --- bioetika --- lääkärin etiikka --- κώδικας ιατρικής ηθικής --- etică medicală --- etica medica --- медицинска етика --- ética médica --- medical ethics --- bioëthiek --- arstieetika --- medizinische Ethik --- medicīniskā ētika --- orvosi etika --- éthique médicale --- medicinos etika --- etikë mjekësore --- medicinska etika --- medische ethiek --- meditsiinieetika --- medicinsk etik --- umetno razmnoževanje --- umělé oplodnění --- riproduzzjoni artifiċjali --- kunstlik viljastamine --- riprodhim artificial --- вештачка репродукција --- вештачко размножавање --- reprodução artificial --- kunstmatige voortplanting --- tehnici de reproducere artificială --- umelá reprodukcia --- kunstig forplantning --- dirbtinis apvaisinimas --- mesterséges megtermékenyítés --- sztuczna prokreacja --- mākslīgās ataudzes metodes --- künstliche Fortpflanzung --- procreazione artificiale --- umjetna oplodnja --- konstgjord befruktning --- зачеване по изкуствен път --- procreación artificial --- artificial reproduction --- τεχνητή τεκνοποίηση --- keinotekoinen lisääntyminen --- inseminnation hos människa --- darování embryí --- oploditev z biomedicinsko pomočjo --- liječenje neplodnosti --- teknika të riprodhimit artificial --- embryodonatie --- spermadonatie --- umelé počatie u ľudí --- darovanie embryí --- dhurim i vezëve --- asszisztált reprodukció --- sperm bank --- вештачко оплодување кај луѓето --- embrija transplantācija --- ιατρικά υποβοηθούμενη τεκνοποίηση --- banca dello sperma --- infertility treatment --- asistovaná reprodukce člověka --- medizinisch unterstützte Fortpflanzung --- artificial fertilisation --- вантелесна оплодња --- riprodhim artificial te njeriu --- fécondation artificielle --- petesejt adományozása --- banka sperme --- fertilizare artificială --- procreare artificială umană --- assisted fertilisation --- fecondazione medicalmente assistita --- hedelmöityshoito --- sperm donor --- spermatozoīdu donors --- tratament pentru infertilitate --- asszisztált humán reprodukció --- spermanluovuttaja --- doação de esperma --- assisterad reproduktion --- spermos donorystė --- банка сперме --- Samenspende --- lekársky asistované počatie --- υποβοηθούμενη αναπαραγωγή ανθρώπων --- донација на сперма --- донатор сперме --- prokreazzjoni artifiċjali umana --- bankë sperme --- artificial human reproduction --- sperm donation --- prokreazzjoni medika assistita --- донација сперме --- донација ембриона --- konceptim i ndihmuar --- procreazione medicalmente assistita --- prokreacja wspomagana medycznie --- embryo donation --- künstliche Befruchtung --- донирање јајце-клетки --- doniranje jajnih stanica --- dhurues i spermës --- embrüodoonorlus --- artificial fertilization --- don de sperme --- fecundación artificial --- зачеване по изкуствен път при човека --- donation af sæd --- лечење неплодност --- dirbtinis žmogaus apvaisinimas --- τράπεζα σπέρματος --- Samenbank --- nevaisingumo gydymas --- egg donation --- asistovaná ľudská reprodukcia --- spermadonation --- fecundação artificial --- kunstig befrugtning --- doniranje embrija --- In-vitro-Fertilisierung --- umělá reprodukce u člověka --- umetna oploditev --- lapsettomuushoito --- procréation artificielle humaine --- oploditev s človeško pomočjo --- spermos bankas --- reprodução humana assistida --- semenska banka --- τεχνητή τεκνοποίηση ανθρώπων --- асистирана репродукция при човека --- embriódonor --- darování spermií --- procréation médicalement assistée --- donación de embriones --- spermabank --- assisterad befruktning --- banque de sperme --- донација на ембрион --- neauglības ārstēšana --- spermapankki --- reproduction humaine assistée --- pagalbinis žmogaus apvaisinimas --- reproducción humana asistida --- embryodonation --- donazione di embrioni --- даряване на сперма --- δωρεά εμβρύων --- medicinski potpomognuta oplodnja --- assisted human reproduction --- darovanie spermií --- alkion luovutus --- donazzjoni ta' sperma --- mākslīgās pavairošanas metodes --- dhurim i embrionit --- mākslīgā apaugļošana --- donazzjoni ta' embrijuni --- procriação medicamente assistida --- sperma adományozása --- fecondazione artificiale --- donatur tal-isperma --- procreación médicamente asistida --- doniranje sperme --- donazione di sperma --- даряване на ембриони --- don d'embryons --- augļa ieņemšana un attīstības sekmēšana ar medicīnas līdzekļu palīdzību --- ИВФ третман --- darovanje semena --- assisted fertilization --- In-vivo-Befruchtung --- banka spermií --- doação de embriões --- keinohedelmöitys --- sædbank --- Embryonenspende --- donación de esperma --- kunstmatige bevruchting --- kiaušinėlio donorystė --- fertilizzazzjoni artfiċjali --- банка за сперма --- ngjizje artificiale --- sztuczne zapłodnienie u ludzi --- riproduzzjoni umana assistita --- umělé reprodukční techniky --- bank tal-isperma --- sperman luovutus --- dzimumšūnu banka --- ВТО --- изкуствено зачеване --- tehnike umjetne oplodnje --- assistierte Reproduktion --- spermatozoīdu ievadīšana --- техники на вештачко оплодување --- dawstwo embrionów --- dhurim i spermës --- konceptim i asistuar --- procreación artificial humana --- riproduzione umana assistita --- procriação artificial humana --- donator sperme --- insemination --- banco de esperma --- медицински помогнато оплодување --- darovanje jajčec --- лечење стерилитета --- bank nasienia --- lombikbébi-program --- dawstwo nasienia --- reproducere umană asistată --- lékařsky asistovaná reprodukce --- spermapank --- лекуване на безплодие --- lisääntymishoidot --- trajtim i mungesës së pjellorisë --- embriono donorystė --- spermadoonorlus --- umelé oplodnenie --- viljatusravi --- konceptim artificial --- riprodhim i asistuar te njeriu --- донација јајне ћелије --- fecundación médicamente asistida --- artificial reproductive techniques --- cilvēku mākslīgā apaugļošana --- donation af embryoner --- léčba neplodnosti --- δωρεά σπέρματος --- procreazione artificiale umana --- liġi tal-familja --- οικογενειακό δίκαιο --- obiteljsko pravo --- Derecho de familia --- perekonnaõigus --- perhelainsäädäntö --- ģimenes tiesības --- family law --- prawo rodzinne --- familjerätt --- семејно право --- družinsko pravo --- e drejta e familjes --- rodinné právo --- породично право --- familierecht --- familieret --- Familienrecht --- šeimos teisė --- семейно право --- dlí teaghlaigh --- dreptul familiei --- családjog --- diritto di famiglia --- direito da família --- Anerkennung der Mutterschaft --- zákon o rodině --- родителско право --- surogatka --- Vruchtbaarheid --- Zaadcel --- Baarmoeder --- Nieuw samengesteld gezin --- Embryo --- Intracytoplasmatische sperma-injectie --- Getuigenis --- Selectie --- bitheitic --- atáirgeadh saorga --- [618] --- Procréation artificielle --- Bioéthique --- Mère porteuse