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This book presents authoritative accounts of the major target enzymes and their inhibitors which are currently the focus of research. The introductory chapters describe the underlying physical and chemical processes of enzyme inhibition and the general principles of inhibitor design using themany sophisticated and computer-based techniques that are now available. Subsequent chapters discuss in detail the wide range of individual target enzymes and inhibitors, emphasizing the factors which affect their usefulness in the clinical context : bioavailability, pharmacokinetics andside-effects.

Enzyme inhibitors --- Enzyme Inhibitors. --- Structure-activity relationships. --- Enzyme Inhibitors --- Inhibitors, Enzyme --- Sulfhydryl Reagents --- Chemistry, Pharmaceutic --- Pharmaceutic Chemistry --- Pharmaceutical Chemistry --- Medicinal Chemistry --- Chemistry, Medicinal --- antagonists & inhibitors --- Chemistry, Pharmaceutical --- Antagonists, Enzyme --- Enzyme antagonists --- Enzymes --- Metabolic inhibitors --- Chemical inhibitors --- Structure-activity relationships --- Therapeutic use&delete& --- Testing --- Antagonists --- Inhibitors --- Enzymology --- Pharmacology. Therapy --- Chemistry, Pharmaceutical. --- Therapeutic use --- Testing. --- Antienzymes --- Chimie pharmaceutique. --- Médicaments. --- Pharmaceutical Preparations. --- Emploi en thérapeutique --- Essais. --- Relations structure-activité. --- Enzyme Inhibitor --- Inhibitor, Enzyme --- Pharmaceutical Preparations