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Our study clearly establishes that the one-third partial hepatectomy is of particular interest in the study of the regenerative response, as In contrast to the two-thirds partial hepatectomy, it can easily be amplified by various factors.
In the first part, infusion of Diprivan (Propofol) increases the DNA synthesis in 10% partial hepatectomy from control value 13.2+/-1.8 to 54.5+/-7.7 (P<0.01),in one-third partial hepatectomy from 41.5+/-3.1 to 102.7+/-11.5 (P<0.001), in sham operation from 7.2+/-1.7 to 23.1+/-3.4 (P<0.01) but not after a two-thirds partial hepatectomy. Infusion in Intralipid emulsion alone also increases the DNA synthesis in 10% partial hepatectomy from 13.2+/-1.8 to 24.3+/-2.0 (P<0.01), in one-third partial hepatectomy from 7.2+/-1.7 to 20.4+/-4.2 (P<0.5) but not in two-thirds partial hepatectomy.
In the second part, a stimulatory effect of HGF administration on the DNA synthesis after a one-third partial hepatectomy, is obtained by two injections, immediately and at 12 hours (from control value 41+/-3.1 to 143+/-27.2 (P<0.001), by continuous infusion during 24 hours (to 109+/-20 P<0.01) or by a single injection at the 10th hour (to 105+/-19.5 O<0.01). By contrast, the administration immediately after the one-third partial hepatectomy seems much less efficient (65+/-18.8).
In the third part, the conversion of one-third into a two-third partial hepatectomy obtains a 24-jour response identical to the one after classic two-thirds partial hepatectomy (315+/-24 versus 333+/-18). By contrast, when the conversion is delayed at 14 hours, this response is markedly reduced (50+/-13).
These results suggest that the one-third partial hepatectomy is an interesting model which is more sensitive and it is susceptible to be modified by various factors such a Diprivan, Intralipid. The magnitude of the regenerative response to a one-third partial hepatectomy is easily modified at around the 10th hour by the administration of HGF or by the further reduction of the liver mass.

Hepatectomy --- Propofol --- Hepatocyte Growth Factor --- Liver Regeneration