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The Carbohydrate Bioengineering Meeting held in Elsinore, Denmark, April 23-26, 1995, gathered 230 scientists, mostly from Europe, with interest in carbohydrate analysis and structure; carbohydrates in medicine and glycopathology; structure, function, application, and protein engineering of carbohydrate active enzymes; oligo- and polysaccharides of industrial interest; and production of carbohydrate containing new materials. The first chapters address glycoconjugates as modulatory and recognition molecules, structure determination using NMR and mass spectrometry, and microdialysis-chip enzyme-based sensors. Active site mutations coupled with crystal structures and synthetic substrate analogue interactions as well as new three-dimensional structures and binding domains for biotechnological applications are included in the chapters. Carbohydrate active enzymes turned out to be a predominant topic. The rapid development in glycobiology and glycotechnology has resulted in an enormous increase in our knowledge on the structure conversion, and application of carbohydrates in industry and medicine.
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Microbial utilization of the inexhuaustible lignocellulosic biomass for the production of industrial chemicals, liquid fuels, protein-rich feed and food, and preparation of cellulose polymers, is an attractive approach to help meet energy and food demands. Whilst biomass has served as substrate in microbial processes for the production of alcoholic beverages for a long time, it is only recently that broader applications of this material have been envisaged. Hemicellulose-derived sugars have many potential uses in the production of industrial chemicals and solvents. Considerable developments have been made, not only in the improvement of yeast and recombinant bacterial strains, but also in the bioprocessing of these organisms during the last two decades. Although the volume of information available on microbial pentose utilization is increasing, the available literature is mostly scattered. A comprehensive account of recent advances in pentose based bioprocesses is provided along with suggestions for future research. An indispensable volume for graduate students of microbiology, biochemistry, biotechnology and biochemical engineering. The needs of industrial microbiologists, environmental scientists and researchers in the area of carbohydrate utilization and metabolism are also catered for. Industrial organizations involved in developing processes for ethanol and other products from non-conventional sources will also find this volume beneficial. Bacteria/metabolism Cellulose Lignin Lignocellulose/Biotechnology MEDICAL/Microbiology Micro-organismen Microbial metabolism Pentosen Pentoses/Metabolism Pentoses/metabolism Stofwisseling
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The proceedings of the Cellucon Trust conference held in Lund, Sweden, in 1993. The latest scientific advances are covered, environmental concerns and the consequent economic costs are dealt with. The papers have surprisingly wide applications across a number of industries, including food processing, pharmaceuticals, chemical processing, civil engineering and composite materials production.
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Biotechnology --- Art
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The proceedings of the Cellucon Trust conference held in Lund, Sweden, in 1993. The latest scientific advances are covered, environmental concerns and the consequent economic costs are dealt with. The papers have surprisingly wide applications across a number of industries, including food processing, pharmaceuticals, chemical processing, civil engineering and composite materials production.
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Biotechnology --- Alsace
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The most productive (`star') bioscientists possessed intellectual human capital of extraordinary scientific and pecuniary value for some 10-15 yrs after Cohen & Boyer's 1973 founding discovery for biotechnology. This extraordinary value was due to the union of still scarce knowledge of the new research techniques and genius to apply these techniques in valuable ways. As in other sciences, star bioscientists were particularly protective of their ideas in the early years of the revolution, tending to collaborate more within their own institution which slowed diffusion to other scientists. Therefore, close, bench-level working ties between stars and firm scientists were needed to accomplish commercialization of the breakthroughs. Where and when the star scientists were actively producing academic publications is a key determinant of where and when commercial firms began to use biotechnology. The extent of collaboration by a firm's scientists with stars is a powerful predictor of its success: for each 9 articles co-authored by an academic star and firm scientists about 3 more products in development, 1 more on the market and 1550 more employees are estimated. Such collaboration with firms, or employment, also results in significantly higher rates of citation to articles written with the firm. The U.S. scientific and economic infrastructure has been quite effective in fostering and commercializing the bioscientific revolution. To provide an indication of international competitiveness, we estimate stars' distribution, commercial involvement and migration across the top 10 countries in bioscience. These results let us inside the black box to see how scientific breakthroughs become economic growth and consider the implications for policy.
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