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Biological chemistry is a major frontier of inorganic chemistry. Three special volumes devoted to Metal Sites in Proteins and Models address the questions: How unusual ("entatic") are metal sites in metalloproteins and metalloenzymes compared to those in small coordination complexes? And if they are special, how do polypeptide chains and co-factors control this? The chapters deal with iron, with metal centres acting as Lewis acids, metals in phosphate enzymes, with vanadium, and with the wide variety of transition metal ions which act as redox centres. They illustrate in particular how the combined armoury of genetics and structure determination at the molecular level are providing unprecedented new tools for molecular engineering.

Binding Sites (Biochemistry). --- Metalloenzymes. --- Metallo-enzymen --- Metalloenzymes --- Metalloproteïnen --- Métalloenzymes --- Métalloprotéïnes --- Bioinorganic chemistry. --- Oxidation-reduction reaction. --- Inorganic chemistry. --- Biochemistry. --- Molecular biology. --- Cell biology. --- Biophysics. --- Biological physics. --- Inorganic Chemistry. --- Biochemistry, general. --- Molecular Medicine. --- Cell Biology. --- Biological and Medical Physics, Biophysics. --- Biological physics --- Biology --- Medical sciences --- Physics --- Cell biology --- Cellular biology --- Cells --- Molecular biochemistry --- Molecular biophysics --- Biochemistry --- Biophysics --- Biomolecules --- Systems biology --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Chemistry --- Inorganic chemistry --- Inorganic compounds --- Composition --- Metalloproteins

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In the past few years there has been the increased recognition that the effects of oxidative stress are not limited to the damage of cellular constituents. There is now evidence that reactive oxygen species (ROS) can alter cell function by acting upon the intermediates, or second messengers, in signal transductions. Such effects on signaling mechanisms probably account for the role of oxidative stress in inflammation, aging, and cancer. This volume brings together internationally recognized researchers in both the major areas covered by the book, oxidative stress and signal transduction. The work is organized in three sections. The first deals with the immediate cellular responses to oxidative stress and the production of second messengers. The second details the connection between second messengers and the gene. The third part looks more closely at the level of the gene.

Oxidative Stress. --- Signal Transduction. --- Second Messenger Systems. --- Gene Expression Regulation. --- Active oxygen in the body --- Stress (Physiology) --- Cellular signal transduction. --- Second messengers (Biochemistry) --- Genetic regulation. --- Oxygène actif dans l'organisme --- Stress --- Transduction du signal cellulaire --- Seconds messagers (Biochimie) --- Régulation génétique --- Oxidative stress --- Pathophysiology. --- Second messengers (Biochemistry). --- Oxygène actif dans l'organisme --- Régulation génétique --- Biochemistry. --- Pharmacology. --- Animal physiology. --- Biochemistry, general. --- Pharmacology/Toxicology. --- Animal Physiology. --- Animal physiology --- Animals --- Biology --- Anatomy --- Drug effects --- Medical pharmacology --- Medical sciences --- Chemicals --- Chemotherapy --- Drugs --- Pharmacy --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Chemistry --- Physiology --- Physiological effect --- Composition --- Second messenger systems (Biochemistry) --- Secondary messengers (Biochemistry) --- Cellular signal transduction --- Gene expression --- Gene expression regulation --- Gene regulation --- Biosynthesis --- Cellular control mechanisms --- Molecular genetics --- Cellular information transduction --- Information transduction, Cellular --- Signal transduction, Cellular --- Bioenergetics --- Information theory in biology --- Oxidation-reduction reaction --- Regulation