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Cette méthode fournit des informations sur les dangers pour la santé qui peuvent résulter d’une exposition à une substance d’essai par voie orale. La détermination d’une toxicité sub-chronique orale utilisant des doses répétées peut être effectuée après que l'information initiale sur la toxicité ait été obtenue à partir d’essai de toxicité aiguë ou répétée (28 jours). La méthode est basée sur l’administration orale répétée de la substance étudiée sur une période prolongée (un niveau de dose, quotidiennement, pendant 90 jours). Cette Ligne directrice utilise principalement des espèces autres que les rongeurs. L’espèce la plus commune employée est le chien (le beagle est fréquemment utilisé). Au moins 8 animaux (4 femelles et 4 mâles) doivent être employés pour chaque groupe d’essai. Trois concentrations, au moins, doivent être utilisées. Le composant testé est administré par gavage, dans des capsules ou via la nourriture ou la boisson. Un essai limite peut être fait quand on n’attend pas d’effet pour une dose de 1000 mg/kg poids corporel/j. Les résultats de l’étude incluent des mesures (le poids au moins une fois par semaine, la consommation de nourriture et d’eau), des observations quotidiennes détaillées (examen ophtalmologique, hématologie, biochimie clinique et analyse d’urine), chaque jour de préférence au même moment, de même qu’une autopsie générale et de l’histopathologie. Un essai sub-chronique de 90 jours correctement effectué devrait fournir une évaluation satisfaisante d'un niveau sans effet.

Chemical tests and reagents --- Chemical reagents --- Reagents, Chemical --- Indicators and test-papers

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First published in 1797, The Columbian Orator helped shape the American mind for the next half century, going through some 23 editions and totaling 200,000 copies in sales. The book was read by virtually every American schoolboy in the first half of the 19th century. As a slave youth, Frederick Douglass owned just one book, and read it frequently, referring to it as a "gem" and his "rich treasure." The Columbian Orator presents 84 selections, most of which are notable examples of oratory on such subjects as nationalism, religious faith, individual liberty, freedom, and slavery, including pieces by Washington, Franklin, Milton, Socrates, and Cicero, as well as heroic poetry and dramatic dialogues. Augmenting these is an essay on effective public speaking which influenced Abraham Lincoln as a young politician. As America experiences a resurgence of interest in the art of debating and oratory, The Columbian Orator--whether as historical artifact or contemporary guidebook--is one of those rare books to be valued for what it meant in its own time, and for how its ideas have endured. Above all, this book is a remarkable compilation of Enlightenment era thought and language that has stood the test of time.

Speeches, addresses, etc. --- Addresses --- Collected papers (Anthologies) --- Discourses --- Orations --- Papers, Collected (Anthologies) --- Festschriften --- Lectures and lecturing --- Enlightenment. --- Frederick Douglass. --- debate. --- early American life. --- eloquence. --- oratory. --- political theory. --- self improvement. --- speaking skills. --- speeches.

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Graphics industry --- Graphic arts --- Deutsches Buch- und Schriftmuseum [Leipzig] --- 09:676 <064> --- 676.267 --- Decorative paper --- -Decorative paper --- -#BIBC:ruil --- Paper --- Handschriften en oude drukken: papier, watermerken--Tentoonstellingscatalogi. Museumcatalogi --- Decorative papers (treated by mechanical means). Patterned paper. Marbled paper. Embossed paper. Cre_*pe paper. Clupak --- Collectors and collecting --- -Private collections --- -Bartsch, Franz --- 676.267 Decorative papers (treated by mechanical means). Patterned paper. Marbled paper. Embossed paper. Cre_*pe paper. Clupak --- 09:676 <064> Handschriften en oude drukken: papier, watermerken--Tentoonstellingscatalogi. Museumcatalogi --- #BIBC:ruil --- Private collections --- Bartsch, Franz,

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Law of civil procedure --- International private law --- Process (Law) --- Judicial assistance --- Conflict of laws --- Civil procedure --- Civil procedure (International law) --- Process --- Abuse of process --- Service of papers --- Service of process --- Summons --- Writs --- Criminal procedure --- Judgments, Foreign --- Civil procedure in international courts --- International civil procedure --- International law --- Conflict of laws - Civil procedure

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Pharmacognosy --- Applied chemical analysis --- Chemical tests and reagents --- Medicinal plants --- Quality control --- Drug plants --- Chemical reagents --- Reagents, Chemical --- Factory management --- Industrial engineering --- Reliability (Engineering) --- Sampling (Statistics) --- Standardization --- Quality assurance --- Quality of products --- Plants, Useful --- Botanical drug industry --- Botany, Medical --- Materia medica, Vegetable --- Psychotropic plants --- Indicators and test-papers