Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Knowledge of the development and evolution of the neural crest sheds light on many of the oldest unanswered questions in developmental biology. What is the role of germ layers in early embryogenesis? How does the nervous system develop? How does the vertebrate head arise developmentally and how did it arise evolutionarily? How do growth factors and Hox genes direct cell differenti­ ation and embryonic patterning? What goes wrong when development is misdi­ rected by mutations or by exposure of embryos to exogenous agents such as drugs, alcohol, or excess vitamin A? In 1988, I was instrumental in organizing the publication of a facsimile reprint of the classic monograph by Sven Horstadius, The Neural Crest: Its properties and derivatives in the light of experimental research, which was originally pub­ lished in 1950. Included with the reprint was my analysis of more recent studies of the neural crest and its derivatives. The explosion of interest in and knowledge of the neural crest over the past decade, however, has prompted me to produce this new treatment. Here, as in my 1988 overview, I take a broad approach to the neural crest, dealing with its discovery, its embryological and evolutionary ori­ gins, its cellular derivatives-in both agnathan and jawed vertebrates or gnathos­ tomes-and the broad topics of migration and differentiation in normal development. Cells from the neural crest are also associated with many develop­ mental abnormalities.

Animal embryology and growth --- Animal psychology and neurophysiology --- Neural crest. --- Animal Physiology. --- Cytology. --- Life sciences. --- Neurobiology. --- Neurosciences. --- Human Anatomy & Physiology --- Health & Biological Sciences --- Neuroscience --- Neural crest --- Biological Evolution --- Neural Crest --- Vertebrates --- Biological Processes --- Embryonic Structures --- Chordata --- Genetic Processes --- Anatomy --- Biological Phenomena --- Genetic Phenomena --- Animals --- Eukaryota --- Phenomena and Processes --- Organisms --- Animal Anatomy & Embryology --- Zoology --- Cell biology. --- Animal physiology. --- Cell Biology. --- Neural sciences --- Neurological sciences --- Medical sciences --- Nervous system --- Animal physiology --- Biology --- Cell biology --- Cellular biology --- Cells --- Neurosciences --- Physiology --- Crest, Neural --- Ganglionic crest --- Ganglionic ridge --- Embryology

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Gene transfer within humans has been an obstacle until about 10 years ago. At that time, it was found that viral vectors were effective carriers of ""healthy genes"" into patients' cells. The problem, however, was that viral vectors proved unnecessarily harmful to humans: subjects experienced inflammatory activity and negative immunological responses to the genes. Viral vectors were also unable to meet the needs of the pharmaceutical community: they were not reproducible in large-scale proportions in cost-effective ways.

DNA-ligand interactions. --- Drug targeting. --- Gene therapy. --- Gene therapy. Genetic vectors. DNA-ligand interactions. Liposomes. Drug targeting. --- Genetic transformation. --- Genetic vectors. --- Liposomes. --- Recombination, Genetic --- Genetic Structures --- Genetic Techniques --- Investigative Techniques --- Genetic Phenomena --- Genetic Processes --- Phenomena and Processes --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Genetic Vectors --- Gene Transfer Techniques --- Transformation, Genetic --- Medicine --- Health & Biological Sciences --- Pathology --- Gene transfer --- Transformation (Genetics) --- Drugs --- Site-specific drug delivery --- Targeting of drugs --- Phospholipid vesicles --- Binding, DNA-ligand --- DNA-ligand binding --- Interactions, DNA-ligand --- Therapy, Gene --- Cloning vectors --- Expression vectors (Genetics) --- rDNA vectors --- Recombinant DNA vectors --- Vectors, Genetic --- Targeting --- Genetic recombination --- Microbial genetics --- Nucleic acids --- Transfection --- Target organs (Anatomy) --- Bilayer lipid membranes --- Cytoplasm --- Phospholipids --- Ligand binding (Biochemistry) --- Genetic engineering --- Therapeutics --- Gene expression --- Molecular cloning --- Recombinant DNA --- Dosage forms

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Protein Expression: A Practical Approach and its companion volume Post-translational Modification: A Practical Approach complete the mini-series of Practical Approach books covering the synthesis and subsequent processing of proteins. Protein Expression: A Practical Approach details the expression of cloned DNA or RNA templates in all the major in vivo and in vitro systems. The in vivo systems covered are cultured mammalian cells, the yeasts Saccharomyces cerevisiae and Pichia pastoris, baculovirus, Xenopus oocytes, and prokaryotic cells. Cell-free systems of both eukarytotes and prokaryotes are described, including the prokaryotic systems that offer copuled transcription- translation. There is also a chapter on monitoring protein expression. The post- translational fate of proteins is covered in Post-Translational Processing: A Practical Approach.

Genetic translation --- Proteins --- Genetic Processes --- Gene Expression --- Peptide Biosynthesis --- Amino Acids, Peptides, and Proteins --- Metabolism --- Biochemical Processes --- Genetic Phenomena --- Chemicals and Drugs --- Biochemical Phenomena --- Metabolic Phenomena --- Phenomena and Processes --- Chemical Processes --- Chemical Phenomena --- Gene Expression Regulation --- Protein Biosynthesis --- Biology --- Health & Biological Sciences --- Genetics --- Protein Biosynthesis, Ribosomal --- Protein Synthesis, Ribosomal --- Ribosomal Peptide Biosynthesis --- mRNA Translation --- Genetic Translation --- Peptide Biosynthesis, Ribosomal --- Protein Translation --- Translation, Genetic --- Biosynthesis, Protein --- Biosynthesis, Ribosomal Peptide --- Biosynthesis, Ribosomal Protein --- Genetic Translations --- Ribosomal Protein Biosynthesis --- Ribosomal Protein Synthesis --- Synthesis, Ribosomal Protein --- Translation, Protein --- Translation, mRNA --- mRNA Translations --- Genetic Code --- Codon, Initiator --- Codon, Terminator --- Chemical Phenomenon --- Chemical Process --- Physical Chemistry Phenomena --- Physical Chemistry Process --- Physicochemical Phenomenon --- Physicochemical Process --- Chemical Concepts --- Physical Chemistry Concepts --- Physical Chemistry Processes --- Physicochemical Concepts --- Physicochemical Phenomena --- Physicochemical Processes --- Chemical Concept --- Chemistry Process, Physical --- Chemistry Processes, Physical --- Concept, Chemical --- Concept, Physical Chemistry --- Concept, Physicochemical --- Concepts, Chemical --- Concepts, Physical Chemistry --- Concepts, Physicochemical --- Phenomena, Chemical --- Phenomena, Physical Chemistry --- Phenomena, Physicochemical --- Phenomenon, Chemical --- Phenomenon, Physicochemical --- Physical Chemistry Concept --- Physicochemical Concept --- Process, Chemical --- Process, Physical Chemistry --- Process, Physicochemical --- Processes, Chemical --- Processes, Physical Chemistry --- Processes, Physicochemical --- Expression Regulation, Gene --- Regulation, Gene Action --- Regulation, Gene Expression --- Gene Action Regulation --- Regulation of Gene Expression --- RNAi Therapeutics --- Gene Regulatory Networks --- Gene Products, Protein --- Gene Proteins --- Protein --- Protein Gene Products --- Proteins, Gene --- Molecular Mechanisms of Pharmacological Action --- Metabolic Phenomenon --- Metabolic Process --- Metabolism Concepts --- Metabolism Phenomena --- Process, Metabolic --- Processes, Metabolic --- Anabolism --- Catabolism --- Metabolic Concepts --- Metabolic Processes --- Concept, Metabolic --- Concept, Metabolism --- Concepts, Metabolic --- Concepts, Metabolism --- Metabolic Concept --- Metabolism Concept --- Phenomena, Metabolic --- Phenomena, Metabolism --- Phenomenon, Metabolic --- Biochemical Concepts --- Biochemical Phenomenon --- Biochemical Process --- Phenomena, Biochemical --- Biochemical Concept --- Concept, Biochemical --- Concepts, Biochemical --- Phenomenon, Biochemical --- Process, Biochemical --- Processes, Biochemical --- Molecular Biology --- Genetic Concepts --- Genetic Phenomenon --- Genetic Process --- Concept, Genetic --- Concepts, Genetic --- Genetic Concept --- Phenomena, Genetic --- Phenomenon, Genetic --- Process, Genetic --- Processes, Genetic --- Biosynthesis, Peptide --- Peptides --- Expression, Gene --- Expressions, Gene --- Gene Expressions --- Gene Expression Profiling --- Proteids --- Biomolecules --- Polypeptides --- Proteomics --- Translation (Genetics) --- Genetic code --- Genetic regulation --- Laboratory manuals --- Synthesis --- biosynthesis --- Gene Expression Regulation. --- Protein Biosynthesis. --- cheical synthesis.