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This book determines adjustable parameters in mathematical models that describe steady state or dynamic systems, presenting the most important optimization methods used for parameter estimation. It focuses on the Gauss-Newton method and its modifications for systems and processes represented by algebraic or differential equation models.

Parameter estimation. --- Gaussian processes. --- Distribution (Probability theory) --- Stochastic processes --- Estimation theory --- Stochastic systems --- Chemical engineering --- Mathematical models. --- Chemistry, Industrial --- Engineering, Chemical --- Industrial chemistry --- Engineering --- Chemistry, Technical --- Metallurgy --- Guaussian processes.

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The G protein-coupled receptors (GPCRs), known to be one of the largest superfamilies in the human genome, underpin a multitude of physiological processes and represent a significant target for bioactive and drug discovery programs. In G Protein-Coupled Receptors in Drug Discovery: Methods and Protocols, experts in the field provide a range of classic and cutting-edge laboratory protocols developed for GPCR research, as well as several current review articles relevant to the area of high throughput GPCR screening, with discussion on GPCR structure and GPCR signalling. Written in the highly successful Methods in Molecular Biology™ series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easy to use, G Protein-Coupled Receptors in Drug Discovery: Methods and Protocols serves to aid all those who wish to further the vital research in their GPCR drug discovery programs.

Molecular biology --- Computational Biology. --- Sequence Analysis, DNA. --- Base Sequence. --- Sequence Analysis, RNA. --- Genetics --- Bioinformatics. --- Nucleotide sequence. --- Amino acid sequence. --- Génétique --- Bio-informatique --- Séquence nucléotidique --- Séquence des acides aminés --- Data processing. --- Informatique --- Bioinformatics --- Amino acid sequence --- Data processing --- -Nucleotide sequence --- #TELE:SISTA --- Analysis, Nucleic acid sequence --- Analysis, Nucleotide sequence --- Base sequence (Nucleic acids) --- DNA sequence --- Nucleic acid sequence analysis --- Nucleotide sequence analysis --- RNA sequence --- Sequence, Nucleotide --- Nucleic acids --- Nucleotides --- Sequence alignment (Bioinformatics) --- Biology --- Embryology --- Mendel's law --- Adaptation (Biology) --- Breeding --- Chromosomes --- Heredity --- Mutation (Biology) --- Variation (Biology) --- Bio-informatics --- Biological informatics --- Information science --- Computational biology --- Systems biology --- Amino acid sequence analysis --- Analysis, Amino acid sequence --- Peptide sequence --- Peptide sequencing --- Protein sequence --- Protein sequencing --- Sequence, Amino acid --- Amino acids --- Proteins --- Analysis --- Génétique --- Séquence nucléotidique --- Séquence des acides aminés --- Nucleotide sequence --- 57.087 --- 57.087 Methods and techniques for parameter estimation. Recording of biological data --- Methods and techniques for parameter estimation. Recording of biological data --- G proteins --- Drug development --- Receptors, G-Protein-Coupled --- Drug Discovery --- 577.122 --- 577.122 Protein metabolism --- Protein metabolism --- Drug Prospecting --- Discovery, Drug --- Prospecting, Drug --- High-Throughput Screening Assays --- Bioprospecting --- G Protein Coupled Receptor --- G-Protein-Coupled Receptor --- G-Protein-Coupled Receptors --- G Protein Coupled Receptors --- Receptor, G-Protein-Coupled --- Receptors, G Protein Coupled --- Development of drugs --- Drugs --- New drug development --- Pharmacology --- Pharmacy --- GTP-binding proteins --- GTP regulatory proteins --- Guanine nucleotide-binding proteins --- Guanine nucleotide regulatory proteins --- Membrane proteins --- Receptors --- Development --- Toxicology. --- Pharmacology/Toxicology. --- Chemicals --- Medicine --- Poisoning --- Poisons --- Toxicology --- Genetics - Data processing