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Pharmacology. --- Pharmacy. --- Biochemistry. --- Pharmacology/Toxicology. --- Biochemistry, general. --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Chemistry --- Medical sciences --- Medicine --- Drugs --- Materia medica --- Pharmacology --- Drug effects --- Medical pharmacology --- Chemicals --- Chemotherapy --- Pharmacy --- Composition --- Physiological effect

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It is with great pleasure that I write this Foreword to the Proceedings of the International Conference on Behçet’s Disease which was held in Berlin in June 2002. This was the first International Conference held under the auspices of the International Society for Behçet’s Disease which was founded in 2000 in Seoul. First, I congratulate our colleagues in Berlin, led by Professor Christos Zouboulis of the Department of Dermatology at the Free University of Berlin, for having organised a most successful conference and for having compiled these proceedings so rapidly. It will be realised immediately on scanning the contents of this book that the conference was truly international with 210 participants from 26 countries, as Professor Zouboulis has noted in his preface. These included basic scientists, epidemiologists, pathologists, clinicians and, importantly, representatives from patient organisations. The latter held their own conference alongside the scientific-medical conference to mutual benefit. The combined session of patients and doctors (abstracts on pp 601 – 626) gave the opportunity for an exchange of information and fruitful discussion. The wide ranging scope of the communications is evident from the index and it was most encouraging to see their origin – from all parts of the world, from senior and junior colleagues and, from many different disciplines. Many communications may be regarded as preliminary reports of research in progress and we look forward to seeing the definitive publications in appropriate journals in due course.

Behçet's disease --- Communicable diseases --- Rheumatology. --- Dermatology. --- Ophthalmology. --- Toxicology. --- Hematology. --- Pharmacology/Toxicology. --- Pharmacology. --- Haematology --- Internal medicine --- Blood --- Drug effects --- Medical pharmacology --- Medical sciences --- Chemicals --- Chemotherapy --- Drugs --- Pharmacy --- Medicine --- Eye --- Skin --- Connective tissues --- Joints --- Diseases --- Physiological effect --- Behcet syndrome --- Behçet triple symptom complex --- Behçet's syndrome --- Triple symptom complex --- Generative organs --- Mouth --- Syndromes --- Uveitis --- Vasculitis

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This second volume of PDR SPECIAL TOPICS contains five review articles, covering nearly the entire field of fungal diseases in humans as well as therapeutic approaches. The main emphasis of the book lies in antifungal therapy: the most relevant information on the present state of the art of antifungal chemotherapy for dermatomycoses, subcutaneous and invasive mycoses is summarized, and open questions and unsolved problems are presented. The first chapter deals with the various growth forms of the pathogenic fungi and classifies them based on their sexual cycle and on their RNA/DNA patterns. The second chapter describes the clinical manifestations of the complete set of human fungal infections known today. In addition, clinical symptoms, data on prevalence, overall importance, and epidemiology are given. The third chapter is devoted to diverse laboratory methods in the field of diagnosis of fungal infections, and the fourth and main chapter presents a complete overview of current antifungal therapy. The increase in fungal infections and the improvement of therapeutical options leading to a demand for reliable antifungal susceptibility testing is the topic of the closing chapter. The volume aims at the practitioner who wants to be abreast of the latest achievements in this field and also presents an ideal instrument for advanced students to further their studies in this important and difficult domain.

Mycoses --- Antifungal Agents --- Antifungal agents --- -Fungal diseases --- Fungal infections --- Fungous diseases --- Mycosis --- Mycotic diseases --- Mycotic infections --- Medical mycology --- Anti-fungal agents --- Antimycotics --- Fungal inhibitory agents --- Inhibitory agents, Fungal --- Therapeutic fungicides --- Anti-infective agents --- Fungicides --- drug therapy. --- therapeutic use. --- Treatment --- -Anti-fungal agents --- Fungal diseases --- therapeutic use --- drug therapy --- Pharmacology. Therapy --- Antifungal agents. --- Treatment. --- Pharmacology. --- Medicine. --- Infectious diseases. --- Pharmacology/Toxicology. --- Medicine/Public Health, general. --- Infectious Diseases. --- Health Workforce --- Drug effects --- Medical pharmacology --- Medical sciences --- Chemicals --- Chemotherapy --- Drugs --- Pharmacy --- Physiological effect

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This volume offers a broad and interdisciplinary view of modern approaches to drug discovery as used by pharmaceutical companies and research institutes. It comprehensively covers proteomics, bioinformatics, screening techniques such as high-throughput-, natural compounds-, and NMR-based-screenings, combinatorial chemistry, compound library design, ligand- and structure-based drug design and pharmacokinetic approaches. Each of the thirteen chapters reviews the theory, background and application of a key technology in drug discovery, complemented by an extensive list of references to the original literature. This concise source of information will be useful for researchers, both in industry and academia, as well as students in the fields of medicinal, pharmaceutical and computational chemistry, bioinformatics, biochemistry, molecular biology and pharmacology. Features and benefits - Structure-based drug design, molecular modeling, bioinformatics, screening methods, combinatorial chemistry and physicochemical concepts in drug discovery are comprehensively covered. - The volume is written from the viewpoint of the "drug researcher" working in the pharmaceutical industry, and also presents chapters on novel approaches developed in academia. - Offers high practical value for young scientists who need a quick introduction to the topic. - Provides an overview of the drug discovery process, particularly for specialized scientists working in drug discovery and pharma-managers.

Drugs --- Pharmaceutical technology --- Pharmaceutical chemistry --- QSAR (Biochemistry) --- Combinatorial chemistry --- Médicaments --- Techniques pharmaceutiques --- Chimie pharmaceutique --- Relations structure-activité quantitatives (Biochimie) --- Chimie combinatoire --- Research --- Data processing --- Recherche --- Informatique --- Combinatorial chemistry. --- Pharmaceutical technology. --- Chemistry, Pharmaceutical --- Biopharmaceutics. --- Drug Compounding --- Research. --- Data processing. --- methods. --- QSAR (Biochemistry). --- Médicaments --- Relations structure-activité quantitatives (Biochimie) --- Methods. --- Pharmacology. --- Analytical chemistry. --- Biochemical engineering. --- Organic chemistry. --- Medical biochemistry. --- Proteomics. --- Pharmacology/Toxicology. --- Analytical Chemistry. --- Biochemical Engineering. --- Organic Chemistry. --- Medical Biochemistry. --- Molecular biology --- Proteins --- Medical biochemistry --- Pathobiochemistry --- Pathological biochemistry --- Biochemistry --- Pathology --- Organic chemistry --- Chemistry --- Bio-process engineering --- Bioprocess engineering --- Biotechnology --- Chemical engineering --- Analysis, Chemical --- Analytic chemistry --- Chemical analysis --- Chemistry, Analytic --- Drug effects --- Medical pharmacology --- Medical sciences --- Chemicals --- Chemotherapy --- Pharmacy --- Physiological effect

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Intended for students of intermediate organic chemistry, this text shows how to write a reasonable mechanism for an organic chemical transformation. The discussion is organized by types of mechanisms and the conditions under which the reaction is executed, rather than by the overall reaction as is the case in most textbooks. The treatment emphasizes unifying principles, showing how common mechanisms link seemingly disparate reactions. Each chapter discusses common mechanistic pathways and suggests practical tips for drawing them. Worked problems are included in the discussion of each mechanism, and “common error alerts” are scattered throughout the text to warn readers about pitfalls and misconceptions that bedevil students. Each chapter is capped by a large problem set. The author has drawn on his own research and the current literature to ensure that appropriate attention is given to topics across the range of modern organic chemistry. The text is unique in its inclusion of a chapter on reactions mediated or catalyzed by transition metals, an area in which mechanistic understanding is now essential. Relatively new topics such as olefin metathesis and cycloaromatization are covered without giving short shrift to more traditional areas such as carbonyl chemistry. The text assumes a basic knowledge of organic chemistry. It can be used either in a formal course or by students working on their own, and will be particularly useful for graduate students studying for qualifying examinations. It will also be useful to students and researchers in biochemistry, pharmacology, and inorganic chemistry.

Organic reaction mechanisms. --- Réactions organiques (Chimie) --- Mécanismes --- 547.08 --- Organic chemistry--?.08 --- Biochemistry. --- Chemistry. --- Chemistry, inorganic. --- Chemistry, Organic. --- Polymers. --- Toxicology. --- Organic reaction mechanisms --- Chemistry --- Physical Sciences & Mathematics --- Physical & Theoretical Chemistry --- Biochemistry --- 547.08 Organic chemistry--?.08 --- Réactions organiques (Chimie) --- Mécanismes --- EPUB-LIV-FT SPRINGER-B --- Pharmacology. --- Inorganic chemistry. --- Organic chemistry. --- Organic Chemistry. --- Biochemistry, general. --- Pharmacology/Toxicology. --- Inorganic Chemistry. --- Polymer Sciences. --- Mechanisms, Organic reaction --- Reaction mechanisms (Chemistry) --- Polymers  . --- Polymere --- Polymeride --- Polymers and polymerization --- Macromolecules --- Inorganic chemistry --- Inorganic compounds --- Drug effects --- Medical pharmacology --- Medical sciences --- Chemicals --- Chemotherapy --- Drugs --- Pharmacy --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Organic chemistry --- Physiological effect --- Composition