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Pharmacogenetics, the use of genetic testing to prescribe and develop drugs, has been hailed as a revolutionary development for the pharmaceutical industry and modern medicine. Supporters of 'personalised medicine' claim the result will be safer, cheaper, more effective drugs, and their arguments are beginning to influence policy debates. Based on interviews with clinicians, researchers, regulators and company representatives, this book explores the impact of pharmacogenetics on clinical practice, following two cases of personalised medicine as they make their way from the laboratory to the clinic. It highlights the significant differences between the views of supporters of pharmacogenetics in industry and those who use the technology at the clinical 'coal face'. Theoretically, this work builds on the developing area of the sociology of socio-technical expectations, highlighting the way in which promoters of new technologies build expectations around it, through citation and the creation of technological visions.

Sociology of health --- Pharmacology. Therapy --- Social Sciences --- Sociology --- Pharmacogenetics --- Social aspects. --- Pharmacology --- Biochemical genetics --- Genetic aspects

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DNA Repair and Replication contains an up-to-date review of general principles of DNA replication and an overview of the multiple pathways involved in DNA repair. Specific DNA repair pathways, including base-excision repair, light-dependent direct reversal of UV-damage, nucleotide-excision repair, transcription-coupled repair, double-strand break repair, and mismatch repair, are each discussed in separate chapters.Selected Contents:-Base Excision Repair-Eukaryotic DNA Mismatch Repair-Double Strand Break Repair-Functions of DNA Polymerases-Somatic Hypermutation: A M

DNA repair. --- DNA replication. --- Chromosomal DNA replication --- DNA --- Replication of DNA --- Deoxyribonucleic acid repair --- Repair, DNA --- Repair mechanisms in DNA --- Biochemical genetics --- Antimutagens --- Replication --- Synthesis

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Histology. Cytology --- Semiology. Diagnosis. Symptomatology --- Histocytochemistry --- Molecular Biology --- Histochemistry --- Molecular biology --- Histochimie --- Biologie moléculaire --- Periodicals. --- Périodiques --- Histocytochemistry. --- Molecular Biology. --- Histochemistry. --- #TS:WDEP --- Cytochemistry --- Periodicals --- Health Sciences --- Life Sciences --- Histology --- Biology --- Cytology, Cell Biology --- Micro and Molecular Biology --- Biochemical Genetics --- Biology, Molecular --- Genetics, Biochemical --- Genetics, Molecular --- Molecular Genetics --- Biochemical Genetic --- Genetic, Biochemical --- Genetic, Molecular --- Molecular Genetic --- Biochemistry --- Genetic Phenomena --- moleculaire biologie

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Since publication of the first edition of Volume III in 1996, a number of areas in fungal biochemistry and molecular biology have both expanded and rapidly advanced, especially those areas that incorporate the new resource of genomics. In light of these developments, all the chapters of this new edition have been fully revised and completely updated. Still further, the text now contains eleven new chapters, which cover either new topics or have been written by new contributing authors. The second edition of Volume III includes: Biochemistry and molecular genetics; regulation of gene expression; organelle biogenesis; response factors influencing metabolism; molecular biology of carbohydrates and lignin; molecular aspects of biochemical pathways.

Fungi --- biochemistry --- molecular biology --- Microbiology. --- Microbial genetics. --- Microbial genomics. --- Plant biochemistry. --- Cell biology. --- Microbial Genetics and Genomics. --- Plant Biochemistry. --- Cell Biology. --- Cell biology --- Cellular biology --- Biology --- Cells --- Phytochemistry --- Plant biochemistry --- Plant chemistry --- Biochemistry --- Botany --- Phytochemicals --- Plant biochemical genetics --- Genomics --- Microbial genetics --- Microorganisms --- Genetics --- Microbiology --- Microbial biology

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RNA --- Molecular biology --- Molecular biology. --- RNA. --- Ribonucleic acid --- Ribose nucleic acid --- Molecular biochemistry --- Molecular biophysics --- Nucleic acids --- Ribose --- Biochemistry --- Biophysics --- Biomolecules --- Systems biology --- Health Sciences --- Life Sciences --- Physiology --- Micro and Molecular Biology --- Molecular Biology. --- Gene Products, RNA --- Non-Polyadenylated RNA --- RNA, Non-Polyadenylated --- Ribonucleic Acid --- Acid, Ribonucleic --- Non Polyadenylated RNA --- RNA Gene Products --- RNA, Non Polyadenylated --- Biopolymers --- Biochemical Genetics --- Biology, Molecular --- Genetics, Biochemical --- Genetics, Molecular --- Molecular Genetics --- Biochemical Genetic --- Genetic, Biochemical --- Genetic, Molecular --- Molecular Genetic --- Genetic Phenomena